| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| The expression of DRA gene and immunological phenomena in the transgenic mice was investigated . 1 ) The DR alpha chain was associated with murine E beta b chain and xenogenic mixed isotype heterodimer DR alpha E beta b was expressed on immunocompetent cells , such as B cells , macrophages , dendritic cells , and thymic epithelial cells , despite that transgenic DRA gene contained only 268 bp of the 5 ' flanking region . 2 ) The DR alpha E beta b molecules as well as E alpha E beta b functioned as major histocompatibility complex class 2 molecules to select T cell repertoire , to stimulate mixed lymphocyte reaction , and to induce proliferation of T cells specific to moth cytochrome c peptide ( MCC 81 103 ) . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| In order to study this question , a well defined MHC class 2 restricted epitope ( residues 88 103 ) from moth cytochrome C ( MCC ) was inserted into the central hypervariable domain of the flagellin of an attenuated strain of Salmonella dublin . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| Positive selection was nearly absent in Iio / 2B4 mice , which display receptors specific for a moth cytochrome c ( MCC ) peptide in the context of Ek . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| To investigate these issues , we have employed tetrameric peptide MHC complexes to fluorescently label and monitor polyclonal populations of thymocytes that are specific for moth cytochrome c ( MCC ) / I Ek . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| T cells expressing two different TCRs were generated by interbreeding 3A9 and AND CD4+ TCR transgenic mice specific for the hen egg lysozyme ( HEL ) peptide 48 62 : 1 Ak and moth cytochrome c ( MCC ) peptide 88 103 : 1 Ek peptide : MHC ligands , respectively . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| H 2K mice injected , intravenously in saline or intraperitoneally in incomplete Freund ' s adjuvant , with large quantities of the immunodominant 1 E ( k ) restricted epitope from moth cytochrome c ( MCC ) 88 103 fail to respond to subsequent immunization with this epitope when administered in complete Freund ' s adjuvant . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| We investigated the influence of positional and structural constraints in the region of the epitope by designing a set of recombinant antigens that each contained the well characterized T cell epitope moth cytochrome c ( MCC ) ( 88 103 ) , which is specifically recognized by the monoclonal antibody ( mAb ) D 4 when complexed with H 2Ek . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| The IAYLKQATK peptide segment is based on moth cytochrome c 95 103 ( MCC 95 103 ) , and the QLRMATPLLMR segment is based on murine 2 CLIP 89 99 M90L ( 2 CLIP 89 99 M90L ) . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| MCC induced apoptosis of LNCaP cells was consistent with a mitochondrial pathway involving mitochondrial disruption , release of cytochrome c , and an increase in Bax protein levels leading to caspase 3 and 7 activation and cleavage of poly ( ADP ribose ) polymerase and nuclear mitotic apparatus protein . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| Herein , we used the 1 E ( K ) restricted T cell epitope of pigeon / moth cytochrome c ( PCC / MCC ( 88 103 ) ) to assess the ability of T cells to recognize ligands containing nitrotyrosine . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| The binding of specific moth cytochrome c ( MCC ) and hemoglobin ( Hb ) peptides to IEk is very sensitive to ionic strength at pH 7 . 5 but not at pH 5 . 4 , indicating that the mechanism of peptide binding is pH dependent . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| C7 / moth cytochrome c [ MCC ] peptide 93 103 / I Ek ) was obtained . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| To investigate this problem , the selection of T cells specific for a well studied combination of MHC + peptide , IEk + moth cytochrome c 88 103 ( MCC ) , was investigated . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| Treating mice with an immunodominant T cell epitope from moth cytochrome c ( MCC ( 88 103 ) ) can induce T cell unresponsiveness under certain conditions of administration . ^^^ |
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| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| These stromal cells supported the development of CD 4 single positive ( SP ) cells in reaggregate co cultures with CD4+ CD8+ thymocytes from TCR transgenic mice , but did not stimulate class 2 MHC restricted , moth cytochrome c ( MCC ) reactive T cells in vitro . ^^^ |
|
| Interacting proteins: P99999 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
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