| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Because amounts of McC in C G dinucleotides vary greatly among species , from apparent nonexistence to substantial proportions , no inference may yet be drawn about the role of such base modifications in DNA . . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| MCC operates with molecule words ( DNA , RNA , proteins ) according to the programme recorded in DNA and RNA . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Two yeast artificial chromosomes ( YACs ) spanning a total distance of 1 . 1 megabase pairs of DNA around the MCC ( for mutated in colorectal carcinoma ) and APC ( for adenomatous polyposis coli ) genes at 5q21 have been isolated and characterized . ^^^ To this end , YACs identified by the MCC gene were screened across a chromosome 5 specific cosmid library to provide a source of DNA probes for genomic scanning . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We used GC clamped denaturing gradient gel electrophoresis to screen for DNA polymorphisms in the following six gene sequences : MCC , p 53 , prealbumin ( transthyretin ) , rhodopsin , S antigen , and TGF alpha . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We used the polymerase chain reaction and DNA content flow cytometric nuclear sorting to examine 30 primary human esophageal cancers for loss of heterozygosity of APC or MCC or both . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Using this model , we found that hydrostatic compressive force stimulated glycosaminoglycan ( GAG ) synthesis , a cartilage phenotype , in MCC and SOS chondrocytes and DNA synthesis in MCC , NSC , and SOS chondrocytes . ^^^ The maximal increase in DNA synthesis , produced by a compressive force of 50 gm / cm2 for 1 minute , was 50 % in NSC chondrocytes , 50 % in SOS chondrocytes , and 30 % in MCC chondrocytes . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| By application of the pressure , DNA synthesis increased in NSC and SOS ( 150 % of control by 50 g / cm2 , 1 min ) , but not so much in MCC in the medium containing 10 % fetal calf serum ( FCS ) . ^^^ The application of the pressure 2 min before the addition of 10 % FCS potentiated the increase by FCS of DNA synthesis in NSC ( 130 % of control ) , but not so much that in SOS and little that in MCC . 3 . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Mcc and Mcc Imm mutants were isolated on plasmids pMccB 17 and pMM 102 by deleting various DNA fragments and by inserting different translocatable elements . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| The production of the antibiotic substance microcin B 17 ( Mcc ) is determined by a 3 . 5 kilobase DNA fragment from plasmid pMccB 17 . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| The maximal increase in DNA synthesis was 200 % in NSC chondrocytes , 90 % in SOS chondrocytes , and slight in MCC chondrocytes . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Analysis of plasmids carrying mcc lacZ gene fusions indicates that all microcin DNA is transcribed in the same direction . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We present details of the morphology , DNA content and immunohistochemistry of these 4 lines and compare their growth patterns with those of SCLC and MCC lines which grow in suspension . . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| In DNA binding studies using a consensus octamer recognition site we have found that 4 of 8 MCC cell lines examined expressed brn 2 in at least trace amounts compared with 3 SCLC cell lines which all expressed brn 2 proteins at high levels . ^^^ This identified a novel DNA binding protein in a subset of MCC cell lines . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Loss of heterozygosity ( LOH ) at APC and MCC gene loci ( both mapped to 5q21 ) was investigated in 24 surgical specimens of primary gastric carcinomas using the polymerase chain reaction after tumor cell enrichment by cell sorting based on differences in DNA content . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| DNA from one patient showed a rearranged pattern which was interpreted as evidence for an inversion of approximately 150 kb , changing the transcriptional orientation of the neighbouring MCC gene and bringing it closer to APC . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| PCR amplification was used to test genomic DNA for an association between allelic polymorphisms in MCC and a flanking gene ( CGL 1 , for the cathepsin G like protein ) on chromosome 14q11 and asthma , rhinitis , and eczema . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that LOH on 3p is a common occurrence in MCC ; however , three tumours for which DNA was also available from a corresponding cell line suggest there may be a subset of MCC whose genesis is independent of deletions of 3p . . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Current knowledge suggest that the change from normal mucosa to a small adenoma may be mediated by mutations of the APC gene and MCC gene on chromosome 5 , by chromosome 5 deletion , by c myc activation , and by DNA hypomethylation . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We analyzed three Merkel cell carcinomas ( MCC ) , applying comparative genomic hybridization ( CGH ) with DNA from paraffin embedded and cultured tumor material as the probes . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of the MCC gene by microinjection in normal NIH3T3 cell lines leads to inhibition of DNA synthesis . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We used seven DNA markers mapped to and around the APC and MCC genes to detect allelic imbalance . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| RFLP studies have indicated a duplication of DNA sequences at the chromosome 5q22 region and showed a breakpoint cluster between the apc and mcc genes in nonpapillary renal cell carcinoma ( RCC ) . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Mycobacterium phlei mycobacterial cell complex ( MCC ) is a cell wall preparation that has mycobacterial DNA in the form of short oligonucleotides complexed on the cell wall surface . ^^^ MCC is not directly cytotoxic towards these cancer cells , but induces apoptosis as determined by nuclear DNA fragmentation and by the release of nuclear mitotic apparatus protein . ^^^ Mycobacterium phlei DNA associated with MCC is responsible for the induction of apoptosis . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Infrequent loss of heterozygosity of APC / MCC and DCC genes in gastric cancer showing DNA microsatellite instability . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We performed immunohistochemical , ultrastructural , terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling ( TUNEL ) , and DNA ladder studies of apoptosis in nine cases of Merkel cell carcinoma ( MCC ) . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Mycobacterial cell wall DNA complexes ( MCC ) exert their anticancer activity by a dual mechanism of action : an indirect effect via the induction of anticancer cytokines and a direct effect on cancer cell division mediated by the induction of apoptosis . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| METHODS : Twenty two cases of paraffin embedded ICC tissue sections were microdissected and genotyped by PCR based DNA sequencing to detect the frequencies of loss of heterozygosity ( LOH ) of tumor suppressor genes APC , MCC , DCC , OGG 1 , p 53 , and RB 1 and of point mutation of Ki ras 2 oncogene . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| MCC was detected in four cases , where DNA was isolated directly from chorionic villi samples ( CVS ) , and in one case with DNA isolated directly from amniotic fluid ( AF ) . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| We previously identified a novel DNA binding protein complex specific for MCC suspension cell lines , termed Merkel nuclear factor ( MNF ) by its binding to the POU 4 family DNA binding consensus sequence . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| The organisation of this MmmSC genome region differed from that of other Mycoplasma species whose complete genome sequences are known , but was similar , by PCR amplification analysis of genomic DNA , to other members of the mycoides cluster , such as Mycoplasma capricolum subsp . capricolum ( Mcc ) . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effects of transforming growth factor beta 1 ( TGF beta 1 ) , insulin like growth factor 1 ( IGF 1 ) and basic fibroblast growth factor ( bFGF ) on DNA and collagen synthesis of mandibular condylar cartilage ( MCC ) of human fetus . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Comparative genomic hybridization ( CGH ) was used to search for gains , high level amplifications and losses of DNA sequences along all chromosome arms in 19 primary Merkel cell carcinomas ( MCC ) . ^^^ Primary MCC expressing DNA alterations were predominantly distinguished in large tumors , and risk of metastatic dissemination was three fold compared to tumors with no DNA alterations . . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| This paper describes the preparation and surface characterization of maleimide activated silicone elastomer ( PDMS ( MCC ) ) followed by covalent functionalization using thiol terminated DNA sequences ( primary oligo ) . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| Comparative mutational profiling for different genomic loci [ 1p36 ( CCM = cutaneous malignant melanoma ] , 3p26 ( OGGI = 8 oxoguanine DNA glycosylase ) , 5q23 ( APC , MCC = mutated in colorectal cancer ) , 9p21 ( p16 / CDKN2A = cyclin dependent kinase 2A ) , 10q23 ( PTEN = phosphatase and tensin homolog [ mutated in multiple advanced cancers 11 ) , 12p12 ( K ras 2 point mutation ) , 17p13 ( TP 53 ) , 18q25 ( DCC= deleted in colorectal cancer ) was carried out on each microdissected tissue target using microsatellite loss of heterozygosity determination or DNA sequencing . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| The proportion of p 53 and p 21 negative samples seems to indicate that correction processes after DNA damage are not activated during MCC pathogenesis , a supposition that is supported by the aggressive nature of this tumour . ^^^ |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P23508 |
Pubmed |
SVM Score :0.0 |
| NA |
|