| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| The activities of porphobilinogen ( PBG ) deaminase ( EC 4 . 3 . 1 . 8 ) , coproporphyrinogen oxidase ( EC 1 . 3 . 3 . 3 ) , protoporphyrinogen oxidase ( EC 1 . 3 . 3 . 4 ) , ferrochelatase ( EC 4 . 99 . 1 . 1 ) and NADH : ferric iron reductase , as well as the synthesis of the enzyme ferrochelatase and the levels of excreted porphyrins , were monitored during DMSO induced differentiation of MEL cells in culture . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| Purified mouse protoporphyrinogen oxidase ( EC 1 . 3 . 3 . 4 ) and ferrochelatase ( EC 4 . 99 . 1 . 1 ) , the two terminal enzymes of the heme biosynthetic pathway , have been reconstituted into phospholipid vesicles , and the kinetics of the enzymes in the reconstituted systems were compared with the values obtained with the free enzymes . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| Coproporphyrinogen oxidase ( EC 1 . 3 . 3 . 3 ) , protoporphyrinogen oxidase ( EC 1 . 3 . 3 . 4 ) , and ferrochelatase ( EC 4 . 99 . 1 . 1 ) catalyze the terminal three steps of the heme biosynthetic pathway . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| We measured protoporphyrinogen oxidase ( PPO ) , which catalyses the oxidation of protoporphyrinogen to protoporphyrin , in both EPP and PV patients and in the offspring of PV patients . ^^^ PPO activity was reduced by 41 % ( P less than 0 . 001 ) in PV patients and in 50 % of their offspring , and by 36 % ( P less than 0 . 001 ) in EPP patients . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| Ferrochelatase ( EC 4 . 99 . 1 . 1 ) was purified and antibodies were raised in rabbits against ferrochelatase and protoporphyrinogen oxidase , respectively . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| We have so far identified 50 different mutations among 4 genes associated with the most common porphyrias showing a high molecular heterogeneity : 22 in the hydroxymethylbilane synthase ( HMBS ) gene ( AIP ) , 7 in the protoporphyrinogen oxidase ( PPOX ) gene ( VP ) , 16 in the uroporphyrinogen decarboxylase ( UROD ) gene ( PCT ) and 5 in the ferrochelatase ( FECH ) gene ( EPP ) . ^^^ |
|
| Interacting proteins: P50336 and P22830 |
Pubmed |
SVM Score :0.0 |
| We then analysed the available single nucleotide polymorphisms ( SNPs ) present at high frequencies in the general population and spreading throughout the FECH , HMBS , PPOX and the CPO genes in four case control association studies . ^^^ |
|