| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| CP , EPP , PCT , and HEP to cutaneous porphyria . ^^^ |
|
| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| In the FCT group physicians were in possession of the results of FCE while this was not the case in the PCT group . ^^^ |
|
| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| The gene hemE determines uroporphyrinogen decarboxylase ( EC 4 . 1 . 1 . 37 ) the gene hemF coproporphyrinogen oxidase ( EC 1 . 3 . 3 . 3 ) and the gene hemG ferrochelatase ( EC 4 . 99 . 1 . 1 ) enzymes . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| We have so far identified 50 different mutations among 4 genes associated with the most common porphyrias showing a high molecular heterogeneity : 22 in the hydroxymethylbilane synthase ( HMBS ) gene ( AIP ) , 7 in the protoporphyrinogen oxidase ( PPOX ) gene ( VP ) , 16 in the uroporphyrinogen decarboxylase ( UROD ) gene ( PCT ) and 5 in the ferrochelatase ( FECH ) gene ( EPP ) . ^^^ |
|
| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| Establishing a biochemical referral centre for photosensitive patients suspected of having porphyria led to the diagnosis of 5 cases of porphyria cutanea tarda ( PCT ) and 2 cases of erythropoietic protoporphyria ( EPP ) among 34 patients referred by dermatologists over a period of 12 months . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| Porphyrin biosynthesis from exogenous ALA and PBG was observed over a period of from 1 to 8 hours in hemolysates of red blood cells from patients with AIP , PCT , and EPP . ^^^ Compared to normals , total porphyrin synthesis was lowered during the entire incubation period in both AIP and EPP , but enhanced in PCT . ^^^ In hemolysates after 1 hour the second component of the pattern in AIP is COPRO , in PCT HEPTA and in EPP PROTO . ^^^ These findings reflect the underlying enzymatic defect : Diminished URO ' gen 1 synthase activity in AIP , diminished URO ' gen decarboxylase activity in PCT , and diminished activity of ferrochelatase in EPP . . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| Of a total of 145 cases , 75 . 2 % were EPP ( 109 cases ) , but only 28 cases ( 19 . 3 % ) were PCT . ^^^ The complication of hepatobiliary aspects in PCT and EPP was noticed . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| There are five main types : porphyria cutanea tarda ( PCT ) ; variegate porphyria ( VP ) ; hereditary coproporphyria ( HC ) ; erythropoietic protoporphyria ( EPP ) ; and congenital erythropoietic porphyria ( CEP ) . ^^^ VP , HC , EPP , and one form of PCT ( type 2 ) are autosomal dominant conditions with low clinical penetrance . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| These observations are in good agreement with the previous report that the in vitro photolysis of Ehrlich ascites carcinoma cells by UP and CP , but not that by PP , was inhibited by catalase and clinical findings with patients with erythropoietic protoporphyria ( EPP ) and porphyria cutanea tarda ( PCT ) . ^^^ The patients with EPP , where the photosensitivity is due to PP , respond well to beta carotene while beta carotene does not protect against the photosensitivity in PCT , in which case the photosensitivity is due to uroporphyrin . . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| The activity was diminished in porphyria cutanea tarda ( PCT ) , acute intermittent porphyria ( AIP ) , variegate porphyria ( VP ) and lead intoxication ( Pb ) , remaining normal in erythropoietic protoporphyria ( EPP ) . delta Aminolaevulinate synthetase ( ALA S ) activity was increased in PCT , AIP , VP and Pb showing no changes in EPP . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| In Japan , relatively popular porphyrias in dermatology clinic are porphyria cutanea tarda ( PCT ) , erythropoietic protoporphyria ( EPP ) and congenital erythropoietic porphyria ( CEP ) . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| Erythropoietic protoporphyria ( EPP ) and porphyria cutanea tarda ( PCT ) are characterized by skin morbidity , induced by pro inflammatory reactive oxygen species generated by the photosensitizing properties of protoporphyrin 9 and uroporphyrin 1 . ^^^ Since H2O2 and PP both readily dissolve in biological membranes , their interaction in the presence of transition metals may contribute to the toxic dark effects of porphyrins as observed in patients with EPP and PCT . . ^^^ |
|
| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| In the 25 year period 1969 1994 , the Department of Dermatology of the Hospital Clinic of Barcelona has been able to study 793 cases of porphyria ( 724 cases of PCT , 27 of EPP , 26 of PV , 5 of CEP , 5 of HEP , 5 of AIP , 1 of HCP ) . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| These results suggest that , in addition to efficacy in the treatment of acute intermittent porphyria ( AIP ) and erythropoietic protoporphyria ( EPP ) , cimetidine is effective in the treatment of PCT . . ^^^ |
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| Interacting proteins: P06132 and P22830 |
Pubmed |
SVM Score :0.0 |
| The NHS ' official Expert Patients Programme website presently states that , `` Pilot EPP courses began at 26 NHS PCT sites across England in May 2002 , and by May 2004 approximately 300 PCTs had either actively implemented pilot courses or had committed to joining . ^^^ The majority of PCTs are now coming to the end of the pilot phase , with many implementing plans to make EPP sustainable for the long term . ' ' The NHS website heralds the pilot `` a success . ' ' A national , postal survey of PCT EPP Leads was undertaken in order to examine both the evolvement of EPP during its pilot stage and future plans for the programme . ^^^ |
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