| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| This finding correlated with a prominent Shc / IGF 1 receptor interaction , tyrosine phosphorylation of Shc , activation of extracellular signal regulated protein kinase ( ERK ) 1 and 2 , and stimulation of DNA synthesis by HMR 1153 and Asp ( B 10 ) insulin . ^^^ In contrast , HMR 1964 produced a marginal activation of the Shc / ERK kinase cascade and was equipotent to insulin in stimulating DNA synthesis in myoblasts . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| NGFI A , NGFI B , NGFI C , ERK 2 and VGF gene . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor and apoptosis initiator NGFI B is a substrate for kinase ERK 2 . ^^^ Thr 142 of NGFI B is comprised in a consensus MAP kinase site and was identified as a preferred substrate for ERK 2 ( but not ERK 1 ) in vitro . ^^^ These results suggest that NGFI B may be a molecular target for ERK 2 signals and thereby a substrate for crosstalk between a growth factor survival pathway and an inducible regulator of apoptosis . . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| ERK 2 prohibits apoptosis induced subcellular translocation of orphan nuclear receptor NGFI B / TR3 . ^^^ In the present study we found that the epidermal growth factor activated ERK 2 in cerebellar granule neurons and that this activation prohibited glutamate induced subcellular translocation of NGFI B . ^^^ Likewise , overexpressed active ERK 2 resulted in a predominant nuclear localization of green fluorescent protein tagged NGFI B . ^^^ Thus , activation of ERK 2 may overcome apoptosis induced subcellular translocation of NGFI B . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| Crosstalk between ERK 2 and RXR regulates nuclear import of transcription factor NGFI B . ^^^ Growth factor EGF activates ERK 2 , which phosphorylates NGFI B and determines if NGFI B is allowed to translocate to mitochondria . ^^^ Likewise , active ERK 2 resulted in a preferential nuclear localization of NGFI B . ^^^ Thus , RXR serves a permissive role for ERK 2 mediated nuclear accumulation of NGFI B . ^^^ This finding represents a novel crosstalk between ERK 2 and RXR signaling pathways , and explains how two independent inhibitors of apoptosis ( EGF and 9 cis retinoic acid ) may cooperate to regulate nuclear targeting of apoptosis inducer NGFI B . . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| In conclusion , this study demonstrates that the ERK pathway is required for AICD of T cells and appears to regulate the induction of Nur 77 and FasL expression during AICD . . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| Alternative , nonapoptotic programmed cell death : mediation by arrestin 2 , ERK 2 , and Nur 77 . ^^^ The activation of the protein kinases Raf 1 , MEK 2 , and ERK 2 is essential for this form of nonapoptotic pcd , leading to the phosphorylation of the orphan nuclear receptor Nur 77 . ^^^ NK ( 1 ) R mediated cell death was inhibited by a dominant negative form of arrestin 2 , Raf 1 , or Nur 77 , by MEK1 / 2 specific inhibitors , and by RNA interference directed against ERK 2 or MEK 2 but not ERK 1 or MEK 1 and against Nur 77 . ^^^ |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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