| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.72890418 |
| Recently , it was demonstrated that NGFI B interacts with Bcl 2 by inducing a conformational change in Bcl 2 , converting it from protector to a killer . 0.72890418^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.8305866 |
| Here , we show that Bcl 2 interacts with orphan nuclear receptor Nur 77 ( also known as TR 3 ) , which is required for cancer cell apoptosis induced by many antineoplastic agents . 0.8305866^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| Retinoid 10 receptor ( RXR ) plays a central role in the regulation of intracellular receptor signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear receptors , including the orphan receptor Nur 77 ( also known as TR 3 [ corrected ] or NGFI B ) , which translocates from the nucleus to mitochondria , where it interacts with Bcl 2 to induce apoptosis . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| Both the transgenic Bcl 2 and zVAD fmk , an inhibitor of caspases , affected all features of Dex induced apoptosis in a similar fashion , by inhibiting cell death and PARP cleavage , and by stabilizing AP 1 , NF kappaB p 50 p50 and NUR 77 levels . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| Our data demonstrate that the molecular program of both anti CD 3 and Ag driven , but not that of superantigen mediated apoptosis involves up regulation of nur 77 , an orphan nuclear receptor , and bim , a BH 3 only member of the proapoptotic bcl 2 protein family , proteins previously implicated to participate in the negative selection . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| However , we show here that Nur 77 mediated apoptosis in thymocytes does not involve cytoplasmic cytochrome c release and can not be rescued by Bcl 2 . ^^^ Thus Nur 77 mediated apoptosis in T cells involves Bcl 2 independent transcriptional activation of several known and novel apoptotic pathways . . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| Proapoptotic nuclear receptor family member Nur 77 translocates from the nucleus to the mitochondria , where it interacts with Bcl 2 to trigger apoptosis . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| We analyzed several knockout and transgenic mouse lines and found that adenosine induced killing of mouse thymocytes requires Bim , occurs independently of `` death receptor ' ' signaling and is inhibited by Bcl 2 and Nur 77 . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| The NK 1R blockade interferes with a caspase independent pathway of apoptosis by affecting both the translocation of Nur 77 into the cytoplasm and the expression of some important Bcl 2 family members such as Bcl 2 and Bak . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| In cancer cells , Nur 77 functions in the nucleus as an oncogenic survival factor , but becomes a potent killer when certain death stimuli induce its migration to mitochondria , where it binds to Bcl 2 and conformationally converts it to a killer that triggers cytochrome c release and apoptosis . ^^^ |
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| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22736 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|