| Interacting proteins: Q96J02 and P22681 |
Pubmed |
SVM Score :0.0 |
| Here we establish that two WW domain HECT E3s , Nedd 4 and Itch , bind Cbl proteins and target them for proteasomal degradation . ^^^ |
|
| Interacting proteins: Q96J02 and P22681 |
Pubmed |
SVM Score :0.0 |
| Deficiency or mutation of some of the E3s like Cbl , Cbl b , or Itch , causes abnormal immune responses such as autoimmunity , malignancy , and inflammation . ^^^ |
|
| Interacting proteins: Q96J02 and P22681 |
Pubmed |
SVM Score :0.0 |
| Several HECT and RING E 3 proteins have now also been linked to the induction and maintenance of immune self tolerance : c Cbl , Cbl b , GRAIL , Itch and Nedd 4 each negatively regulate T cell growth factor production and proliferation . ^^^ |
|
| Interacting proteins: Q96J02 and P22681 |
Pubmed |
SVM Score :0.0 |
| Third , the compromise of effector T cell function is mediated by the enhanced induction of anergy inducing factors cbl b , c cbl ( cbl is abbreviation for Casitas B lymphoma ) , Itch , and Nedd 4 . ^^^ |
|
| Interacting proteins: Q96J02 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|