| Suppressors of T cell receptor signaling Sts 1 and Sts 2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases . ^^^ Herein , we describe the identification of two novel Cbl interacting proteins , p 70 and Clip 4 ( recently assigned the names Sts 1 and Sts 2 , respectively ) , that inhibit endocytosis of epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptor . ^^^ Sts 1 and Sts 2 contain SH 3 domains that interacted with Cbl , Ub associated domains , which bound directly to mono Ub or to the EGFR / Ub chimera as well as phosphoglycerate mutase domains that mediated oligomerization of Sts 1 / 2 . ^^^ |