| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.63285839 |
| Cbl associates with Pyk 2 and Src to regulate Src kinase activity , alpha ( 5 ) beta ( 3 ) integrin mediated signaling , cell adhesion , and osteoclast motility . 0.63285839^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.64227669 |
| Both SETA and AIP 1 interacted with focal adhesion kinase ( FAK ) and proline rich tyrosine kinase 2 ( PYK 2 ) , and c Cbl interacted with PYK 2 . 0.64227669^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Regulation of Syk function occurred through interaction with the Cbl protein , itself a PTK substrate in this system . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl is a prominent PTK substrate suggesting a pivotal role for it in early signal transduction events . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Negative regulation of PTK signalling by Cbl proteins . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Src forms a complex with Pyk 2 and Cbl after adhesion induced stimulation of alpha ( 5 ) beta ( 3 ) integrin . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| In addition , osmotic shock induced the tyrosine phosphorylation of several discrete proteins including Cbl , p 130 ( cas ) , and the recently identified soluble tyrosine kinase , calcium dependent tyrosine kinase ( CADTK ) . ^^^ In contrast , insulin had no effect on CADTK but stimulated the tyrosine phosphorylation of Cbl and the tyrosine dephosphorylation of pp 125 ( FAK ) and p 130 ( cas ) . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Several of these proteins were identified and include protein tyrosine kinase 2 ( also known as CAKbeta , RAFTK , and CADTK ) , pp 125 focal adhesion tyrosine kinase , pp 130 Crk associated substrate , paxillin , and Cbl . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| UTP , ionomycin , and phorbol ester ( phorbol 12 myristate 13 acetate ) increased MAP kinase activity and also promoted the tyrosine phosphorylation of RAFTK , the epidermal growth factor ( EGF ) receptor , SHC , and p 120 ( cbl ) . ^^^ AG 1478 , a tyrphostin selective for the EGF receptor , reduced the activation of MAP kinase , the tyrosine phosphorylation of SHC , the association of Grb 2 with SHC , and the tyrosine phosphorylation of the EGF receptor and p 120 ( cbl ) but did not block the tyrosine phosphorylation of RAFTK . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| These data suggest that high glucose specifically inhibits insulin stimulated NO synthesis and down regulates some aspects of insulin signaling , including the CAP Cbl signaling pathway , yet this is not a result of reduced PKB mediated eNOS phosphorylation at Ser 1177 . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| We report here the identification of the 120 kDa 14 3 3tau binding phosphoprotein present in activated T cell lysates as Cbl , a protooncogene product of unknown function which was found recently to be a major protein tyrosine kinase ( PTK ) substrate , and to interact with several signaling molecules including PI 3 K , in T lymphocytes . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl is a protein tyrosine kinase ( PTK ) substrate that becomes phosphorylated after engagement of numerous cell surface receptors including the TCR . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| In marked contrast to the c Cbl knockout mouse , we found no evidence of enhanced activity of the ZAP 70 PTK in thymocytes from the TKB domain mutant mouse . ^^^ However , the TKB domain mutant mouse does show aspects of enhanced signaling that parallel those of the c Cbl knockout mouse , but these involve the constitutive activation of Rac and not enhanced PTK activity . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Using purified proteins , we studied the ability of Syk , Fyn , and Abl to differentiate between tyrosines in a common PTK substrate , c Cbl . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| To illustrate this functional versatility , we present three specific examples : the SAP , Cbl and SOCS families of SH 2 containing proteins , which play key roles in immune responses , termination of PTK signaling , and cytokine responses . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| The identity of c Cbl as an E 3 ubiquitin ligase unveiled the existence of an important negative regulatory pathway involved in maintaining homeostasis in protein tyrosine kinase ( PTK ) signaling . ^^^ The major sections of the review are as follows : Structure and genomic organization of Cbl proteins ; Phosphorylation of Cbl ; Interactions of Cbl ; Localization of Cbl ; Mechanism of effects of Cbl : ( a ) Ubiquitylation dependent events : This section elucidates the mechanism of Cbl mediated downregulation of EGFR and details the PTK and non PTKs targeted by Cbl . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| PMA treatment of FLG 29 . 1 cells induced a strong increase in the expression of p 120 Cbl and Pyk 2 kinase , which are putative Src substrates . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that cross linking of alpha4beta1 by anti alpha 4 antibody induces tyrosine phosphorylation of Pyk 2 , Shc , and Cbl as well as binding of the adaptor protein CrkL with Cbl in a murine hematopoietic cell line , 32D / EpoR Wt . ^^^ In addition , adhesion of 32D / EpoR Wt cells to immobilized H 296 , a recombinant fibronectin peptide specific for alpha4beta1 , induced tyrosine phosphorylation of Jak 2 , the erythropoietin receptor ( EpoR ) , and the IL 3 receptor beta subunit as well as Pyk 2 , Shc , and Cbl . ^^^ |
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| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Interestingly , although the FAK related kinase Pyk 2 interacts with c Src and c Cbl , its activation is not disrupted in the absence of functional beta 3 . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| During development of the skeleton , osteoclast ( OC ) recruitment and migration are required for the vascular invasion of the cartilaginous anlage and the ossification of long bones . c Cbl lies downstream of the vitronectin receptor and forms a complex with c Src and Pyk 2 in a signaling pathway that is required for normal osteoclast motility . ^^^ |
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| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Recruitment of Pyk 2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites . ^^^ Protein tyrosine kinase Pyk 2 and multifunctional adaptor protein Cbl are implicated in the regulation of the cytoskeleton in several cell types . ^^^ We report that Pyk 2 and Cbl form a signaling complex that is translocated to lipid rafts and is enriched in growth cones of differentiating PC 12 cells following growth factor stimulation . ^^^ We found that Pyk 2 and Cbl interacted with the adaptor protein ArgBP 2 , which also bound to flotillin 1 , a component of lipid raft microdomains . ^^^ In addition , Pyk 2 , Cbl and ArgBP 2 were found co localized with actin in axons and growth cones of differentiated PC 12 cells . ^^^ |
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| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| After integrin engagement , Pyk 2 recruits Src and the adaptor protein Cbl , forming a molecular signaling complex that is critical for cell migration , and deletion of any molecule in this complex disrupts podosome ring formation and / or decreases osteoclast migration . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| ArgBP 2 is directly linked to intracellular signaling cascades by its interaction with Abl family kinases , Pyk 2 and the ubiquitin ligase Cbl . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Once recruited to the activated integrins , especially alphavbeta 3 ) , by the adhesion tyrosine kinase Pyk 2 , Src binds and phosphorylates Cbl and Cbl b , homologous multisite adapter proteins with ubiquitin ligase activity . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the complex containing cFms and alpha ( 5 ) beta ( 3 ) also contained a number of other signaling molecules including Pyk 2 , p 130 ( Cas ) and c Cbl , known downstream regulators of the integrin mediated signaling pathways in osteoclasts . ^^^ |
|
| Interacting proteins: Q14289 and P22681 |
Pubmed |
SVM Score :0.0 |
| CCK stimulated an association of Lyn with PKC delta , Shc , p 125 ( FAK ) and PYK 2 as well as with their autophosphorylated forms , but not with Cbl , p 85 , p 130 ( CAS ) or ERK 1 / 2 . ^^^ |
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