| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.7699057 |
| The induced association of Crkl with Cbl , Hef 1 , and Fc gamma RI gamma after Fc gamma RI activation and the constitutive association between C3G and Crkl provide the first evidence that a Fc gamma RI gamma Crkl C3G complex may link ITAM receptors to the activation of Rap 1 in myeloid cells . . 0.7699057^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| CrkL was constitutively associated with a substantial amount of the guanine nucleotide exchange protein C3G , and a fraction of the C3G protein was coimmunoprecipitated with Cbl in activated Jurkat T cells . ^^^ Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| The adapter protein CrkL was associated with both phosphorylated Cbl and the guanidine nucleotide releasing factor C3G , which catalyzes guanosine triphosphate ( GTP ) exchange on Rap 1 . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Crk is an SH 2 and SH 3 domain containing adaptor protein that has been reported to associate with p130cas , paxillin , c cbl , c abl , Sos , and C3G in vitro . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Recent studies have also identified a novel signaling pathway initiated by the interaction of mammalian Cbl proteins with the SH 2 domains of Crk adaptor molecules , which results in Cbl ' s linkage with C3G , a guanine nucleotide exchange protein for Rap 1 family of small G proteins . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| In both fibroblasts and hematopoietic cells , individual mutations or deletions of each SH 2 and SH 3 domain abrogated transformation and adhesion , respectively , indicating that interactions with other proteins such as Cbl and paxillin ( SH 2 domain ) and Abl , Sos , and C3G ( N terminal SH 3 domain ) are essential for biological activity . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| We had previously shown that C3G , an activator of Rap 1 , associates with the Crk adaptor proteins in B cells and that BCR engagement causes Crk to bind to the Cas and Cbl docking proteins . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration . ^^^ Interestingly , overexpression of C3G also enhanced migration , suggesting that a Cbl Crkl C3G complex may be involved in migration signaling in Ba / F3 cells . ^^^ These data suggest that Crkl is involved in signaling pathways that regulate migration , possibly through a complex with Cbl and C3G . . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| We find that Rap 1 and proposed regulators of Rap 1 ( the proto oncogene product Cbl , Crk family adaptor proteins , and the Rap 1 guanine nucleotide exchange factor C3G ) are expressed at equivalent levels in both double negative and double positive murine thymocytes . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Here we show that phosphorylated Cbl recruits the CrkII C3G complex to lipid rafts , where C3G specifically activates the small GTP binding protein TC 10 . ^^^ This process is independent of PI ( 3 ) K , but requires the translocation of Cbl , Crk and C3G to the lipid raft . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| The overexpression of a CAP mutant in which the SoHo domain had been deleted ( CAPDeltaSoHo ) prevented the translocation of Cbl to lipid rafts and subsequently blocked the recruitment of CrkII and C3G . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| This leads to antigen receptor independent phosphorylation of Cbl ( Casitas B lineage lymphoma ) and C3G . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that PKA ' s activation of Rap 1 was mediated by the Rap 1 guanine nucleotide exchange factor C3G , the adaptor Crk L , the scaffold protein Cbl , and the tyrosine kinase Src . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Previous studies have proposed that Cbl is also a positive regulator of CrkL C3G signalling , which leads to Rap 1 activation . ^^^ Remarkably , the membrane translocation of C3G , its association with CrkL , and the guanine nucleotide exchange activity of C3G were all increased in Cbl ( / ) thymocytes . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| Such translocation temporally matches the insulin stimulated movement of Cbl and CrkII in flotillin 1 / GLUT4 containing domains , as well as the activation of the GDP GTP exchange factor C3G . ^^^ Thus , the activation of the Cbl / C3G / TC10 dependent pathway , which occurs before flotillin 1 / GLUT4 containing domains reach the plasma membrane , is flotillin 1 mediated and follows the activation of the PI3K mediated signaling . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| TC 10 activation by insulin is catalyzed by the exchange factor C3G , which is translocated to lipid rafts along with its binding partner CrkII as a consequence of Cbl tyrosine phosphorylation by the insulin receptor . ^^^ |
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| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
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