| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :1.0156405 |
| N terminal Cbl interacts with SLAP in vivo and in vitro in a tyrosine phosphorylation independent manner . 1.0156405^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.75386167 |
| In antigen receptor stimulated cells , SLAP 2 associated with several tyrosine phosphorylated proteins , including the ubiquitin ligase Cbl . 0.75386167^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.75778082 |
| Following stimulation of primary thymocytes with anti CD 3 and anti CD 28 , SLAP 2 coimmunoprecipitates with tyrosine phosphorylated c Cbl and an unidentified protein of approximately 72 kDa . 0.75778082^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.50503997 |
| The SLAP 2 5 transcript encodes a putative protein of 210 amino acids that lacks the c Cbl interaction region , and consequently is impaired in its ability to both bind to c Cbl , and inhibit TCR signalling relative to SLAP 2 . . 0.50503997^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.0 |
| SLAP 2 interacts with Cbl in vivo in a phosphorylation independent manner and with ZAP 70 and T cell receptor zeta chain upon T cell receptor activation . ^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.0 |
| The adaptor molecule SLAP and E 3 ubiquitin ligase c Cbl each regulate expression of T cell receptor ( TCR ) CD 3 on thymocytes . ^^^ TCR CD 3 expression was similar in the absence of SLAP and / or c Cbl . ^^^ SLAP and c Cbl were found to interact , and their expression together downregulated CD3epsilon . ^^^ This required multiple domains in SLAP and the ring finger of c Cbl . ^^^ Furthermore , expression of SLAP and c Cbl together induced TCRzeta ubiquitination and degradation , preventing the accumulation of fully assembled recycling TCR complexes . ^^^ |
|
| Interacting proteins: Q13239 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|