| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.63902358 |
| The interactions between SLP 76 and Cbl and SLP 76 and Grb 2 are present in resting U937IF cells . 0.63902358^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :1.1594833 |
| SLP 76 , a recently cloned Grb 2 associated protein , was strongly tyrosine phosphorylated after Fc gammaRI stimulation and was associated with both Cbl and Grb 2 . 1.1594833^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Some adapter proteins , such as SLP 76 , Vav , and LAT , positively regulate TCR mediated signal transduction , whereas others , such as Cbl , play an inhibitory role . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| The N terminal SH 3 domain of GrpL binds c Cbl while the C terminal SH 3 domain binds B cell linker protein and SH 2 domain containing leukocyte protein of 76 kDa . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| T cell receptor zeta ( TcRzeta ) / CD3 ligation initiates a signaling cascade that involves src kinases p 56 ( lck ) and zeta associated protein 70 , leading to the phosphorylation of substrates such as TcRzeta , Vav , SH 2 domain containing leukocyte protein 76 ( SLP 76 ) , cbl , and p120 / 130 . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Perturbed regulation of ZAP 70 and sustained tyrosine phosphorylation of LAT and SLP 76 in c Cbl deficient thymocytes . ^^^ At this time , ZAP 70 from both normal and c Cbl / thymocytes becomes hyperphosphorylated ; however , only in normal thymocytes does this correlate with ZAP 70 down regulation and a diminished ability to phosphorylate LAT and SLP 76 . ^^^ In contrast , c Cbl deficient thymocytes display altered phosphorylation kinetics , for which LAT phosphorylation is increased and SLP 76 phosphorylation is sustained . ^^^ These findings provide evidence that c Cbl is involved in the negative regulation of the phosphorylation of LAT and SLP 76 by ZAP 70 . . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Our results provide the first evidence that FcalphaR mediated signals modulate a multimolecular adaptor protein complex containing Grb 2 , Shc , SHIP , CrkL , Cbl , and SLP 76 . ^^^ The complex adapter proteins , Cbl and SLP 76 , are physically associated in myeloid cells and both proteins undergo tyrosine phosphorylation upon FcalphaR stimulation . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| The transmembrane adapter LAT coprecipitates with SLP 76 and PLCgamma 2 , as well as with a number of other adapter proteins , some of which have not been previously described in platelets , including Cbl , Grb 2 , Gads , and SKAP HOM . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Upon CD 3 CD4 ligation , TCR zeta phosphorylation , ZAP 70 recruitment to the p21 / p23 TCR zeta phosphoisomers , ZAP 70 phosphorylation , as well as p 56 ( lck ) , c Cbl and Slp 76 phosphorylation , were all markedly increased in CD45R0 ( + ) compared with CD45RBC ( + ) cells . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Z / 3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat and Slp 76 independent signaling mechanism . ^^^ Furthermore , 70Z / 3 Cbl induced activation of NFAT , a PLC gamma 1 / Ca ( 2+ ) dependent transcriptional event , required Zap 70 , but was independent of Slp 76 , an adapter required for TCR induced NFAT activation . ^^^ These results suggest that 70Z / 3 Cbl and PLC gamma 1 form a TCR , Lat and Slp 76 independent complex that leads to PLC gamma 1 phosphorylation and activation . . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Interactions with SH 2 domain adapters [ growth factor receptor binding protein 2 ( Grb 2 ) , Cbl , Slp 76 ] and SH 3 domain adapters ( HS 1 , cortactin , CD2BP3 ) were attenuated by inhibition of Kit kinase activity . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| On the other hand , we confirmed previously mapped Lck SH 3 binding sites in ADAM 15 , HS 1 , SLP 76 , and NS5A , and identified putative Lck SH 3 binding sites of Sam 68 , FasL , c Cbl , and Cbl b . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| Either the SH 3 or C terminal SH 2 domain of PLCgamma 1 , with the participation of Vav 1 , c Cbl and Slp 76 , are required to stabilize PLCgamma 1 recruitment . ^^^ |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|