| Interacting proteins: P68036 and P22681 |
Pubmed |
SVM Score :0.65483222 |
| UbcH 7 interacted with the wild type c Cbl RING finger domain but not with a RING finger domain that lacks the amino acids that are deleted in 70Z Cbl , an oncogenic mutant of c Cbl . 0.65483222^^^ |
|
| Interacting proteins: P68036 and P22681 |
Pubmed |
SVM Score :0.56803066 |
| In vitro , c Cbl forms a stable complex with the ubiquitin conjugating enzyme UbcH 7 , but active Src destabilizes this interaction . 0.56803066^^^ |
|
| Interacting proteins: P68036 and P22681 |
Pubmed |
SVM Score :0.74492318 |
| UbcH 7 , acting intimately with c Cbl , was decreased in level compared to A431P . 0.74492318^^^ |
|
| Interacting proteins: P68036 and P22681 |
Pubmed |
SVM Score :0.51548614 |
| In the presence of Nef , lipid raft Cdc 42 is activated and forms a ternary complex between the c Cbl interacting protein p85Cool 1 / betaPix and c Cbl , displacing UbcH 7 from rafts . 0.51548614^^^ |
|
| Interacting proteins: P68036 and P22681 |
Pubmed |
SVM Score :0.0 |
| Correlative evidence showed the failure of hSpry2DeltaN11 and mSpry 4 , both deficient in c Cbl binding , to instigate these effects . hSpry 2 interacts specifically with the c Cbl RING finger domain and displaces UbcH 7 from its binding site on the E 3 ligase . ^^^ |
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