| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| We examined the growth and differentiation responses and tyrosine phosphorylation of the intracellular signaling proteins including Jak 2 , Tyk 2 , Stat 3 , Stat 5 , Vav , SHPTP 2 , Cbl , Shc and Shc associated p 145 when receptor stimulation occurred after thrombopoietin ( TPO ) binding . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| To investigate the signaling processes induced by thrombopoietin , we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak 2 , Tyk 2 , Shc , Stat 3 , Stat 5 , p 120 ( c cbl ) and other proteins in human platelets . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Signaling factors that associate with activated erythropoietin ( Epo ) receptor complexes include phospholipase C gamma , phosphatidylinositol 3 kinase , SHIP , Shc , Grb 2 , Cbl , Crk l , HCP , Syp , and STAT 5 . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| In addition , p 100 is precipitated by Grb 2 glutathione S transferase fusion proteins , an interaction largely mediated by the Grb 2 SH3 domains . p 100 appears to be distinct from JAK 2 , Vav , STAT 5 , and c Cbl . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Crkl , an SH2 / SH3 adapter protein , becomes coimmunoprecipitated specifically with STAT 5 from erythropoietin stimulated erythroid cells ; although it was shown to become associated with c Cbl in the studies using cell lines . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Co expression of APS and c Cbl , but not expression of either alone inhibited EPO dependent STAT 5 activation in 293 cells . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| We have expanded this observation by examining the effects of progestins in the cytoplasm ( level 2 ) where progestins regulate several intracellular effectors by increasing the levels and altering the subcellular compartmentalization of Stat 5 , increasing the association of Stat 5 with phosphotyrosine containing proteins and tyrosine phosphorylation of JAK 2 , Cbl , and Shc , and potentiating EGF stimulated p42 / p44 MAPKs , p 38 MAP kinase , and JNK activities . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Such transformation in H7gag akt / RafCAAX was accomplished in the absence of active versions of Shc or cbl , and there was no evidence of Stat activity and only modest amounts of bcl xL , a Stat 5 transcriptional target protein , all of which characterized the cells transformed by BCR ABL . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Here we report that murine embryonic fibroblasts derived from c Cbl deficient mice display significantly increased levels of STAT 1 and STAT 5 protein . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Forced expression of c Cbl did not affect GH stimulated STAT 5 tyrosine phosphorylation , nuclear translocation , nor binding to DNA but markedly abrogated GH stimulated STAT 5 mediated transactivation . c Cbl overexpression resulted in increased ubiquitination and proteosomal degradation of STAT 5 and increased degradation of GH stimulated tyrosine phosphorylated STAT 5 . ^^^ Cellular pretreatment with the proteosomal inhibitor MG 132 reversed the effect of c Cbl overexpression with prolonged duration of GH stimulated STAT 5 tyrosine phosphorylation and restoration of STAT 5 mediated transcription . ^^^ Thus , c Cbl is a negative regulator of GH stimulated STAT 5 mediated transcription by direction of STAT 5 for proteosomal degradation . . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| Crk proteins were found to be involved in the early steps of lymphocyte activation through their SH 2 mediated transient interaction with signal transducing molecules , such as Cbl , ZAP 70 , CasL , and STAT 5 . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| TEL / ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins , including rasGAP , CBL , STAT 5 , PI3K , SHP 2 , Dok , and SHC . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| PY proteins identified by microsequencing and Western blotting include Cbl , STAT 3 , STAT5a , STAT5b , SHP 1 , Shc , and two novel proteins pp 57 and pp 37 . ^^^ CSF 1 induced the de novo recruitment of Cbl , STAT 3 , STAT5a , STAT5b , p 85 , SHP 1 , Shc , vimentin , and Grb 2 to complexes and caused pre existing complexes involving Vav , elongation factor 1alpha , and F actin to increase in size . ^^^ |
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| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
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