| Interacting proteins: P35968 and P22681 |
Pubmed |
SVM Score :0.0 |
| Our study shows that VEGFR 2 promotes phosphorylation of c Cbl , but activation , ubiquitylation , and down regulation of VEGFR 2 are not influenced by c Cbl activity . ^^^ |
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| Interacting proteins: P35968 and P22681 |
Pubmed |
SVM Score :0.0 |
| Casitas B lineage lymphoma ( Cbl ) activation ( Flk 1 . ^^^ Cbl association , tyrosine phosphorylation of the Cbl bound Flk 1 , and tyrosine phosphorylation of Cbl ) in bovine aortic endothelial cells ( BAECs ) . ^^^ Cbl activation , the Flk 1 blocker SU 1498 had no detectable effect on the shear induced integrin activation , suggesting that integrins and Flk 1 play sequential roles in the signal transduction hierarchy induced by shear stress . ^^^ |
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| Interacting proteins: P35968 and P22681 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor dependent down regulation of Flk 1 / KDR involves Cbl mediated ubiquitination . ^^^ Furthermore , VEGF stimulation of BAECs or COS 7 cells transiently transfected with Flk 1 results in the phosphorylation of the ubiquitin ligase Cbl , the enhanced association of Cbl with Flk 1 , and the relocalization of Cbl to vesicular structures in BAECs . ^^^ Overexpression of Cbl in COS 7 cells enhances VEGF induced ubiquitination of Flk 1 , whereas a Cbl mutant lacking the ubiquitin ligase RING finger domain , 70Z / 3 Cbl , does not . ^^^ Moreover , expression of Cbl in contrast to 70Z / 3 Cbl inhibits the Flk 1 dependent activation of eNOS and , thus , NO release . ^^^ In BAEC overexpressing Cbl , the degradation of Flk 1 upon VEGF stimulation is accelerated compared with cells transfected with a control vector ( green fluorescent protein ) . ^^^ |
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| Interacting proteins: P35968 and P22681 |
Pubmed |
SVM Score :0.0 |
| Shear stress and VEGF activate IKK via the Flk 1 / Cbl / Akt signaling pathway . ^^^ These effects were inhibited by SU 1498 , a specific Flk 1 inhibitor , and by a negative mutant of Casitas B lineage lymphoma ( Cbl ) with tyrosine to phenylalanine mutations at sites 700 , 731 , and 774 ( Cbl ( nm ) ) . ^^^ Because Flk 1 and Cbl form a complex upon shearing or VEGF applications ( 50 ) , these results suggest that shear stress and VEGF activate IKK via the receptor Flk 1 and its recruitment of the adapter protein Cbl . ^^^ Furthermore , SU 1498 and Cbl ( nm ) abolished the shear and VEGF induced Akt activity , indicating that Akt acts at a level downstream to Flk 1 and Cbl . ^^^ Therefore , our results indicate that the signaling events induced by shear stress and VEGF converge at the membrane receptor Flk 1 and that these stimuli share the Flk 1 / Cbl / Akt pathway in activating IKK activation . . ^^^ |
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| Interacting proteins: P35968 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
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