| Interacting proteins: P29597 and P22681 |
Pubmed |
SVM Score :0.0 |
| Interaction of the c cbl proto oncogene product with the Tyk 2 protein tyrosine kinase . ^^^ The c cbl proto oncogene product ( p120cbl ) forms a stable complex with the Tyk 2 protein tyrosine kinase in various human cell lines of diverse hematopoietic origin . ^^^ |
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| Interacting proteins: P29597 and P22681 |
Pubmed |
SVM Score :0.0 |
| We examined the growth and differentiation responses and tyrosine phosphorylation of the intracellular signaling proteins including Jak 2 , Tyk 2 , Stat 3 , Stat 5 , Vav , SHPTP 2 , Cbl , Shc and Shc associated p 145 when receptor stimulation occurred after thrombopoietin ( TPO ) binding . ^^^ |
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| Interacting proteins: P29597 and P22681 |
Pubmed |
SVM Score :0.0 |
| To investigate the signaling processes induced by thrombopoietin , we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak 2 , Tyk 2 , Shc , Stat 3 , Stat 5 , p 120 ( c cbl ) and other proteins in human platelets . ^^^ |
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| Interacting proteins: P29597 and P22681 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in response to IFN alpha treatment of cells , the SH 2 domain of Fyn interacts with the Tyk 2 associated c cbl proto oncogene product . ^^^ |
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| Interacting proteins: P29597 and P22681 |
Pubmed |
SVM Score :0.0 |
| In contrast , STAT 2 and STAT 3 expression , as well as the levels of the tyrosine kinases Jak 1 and Tyk 2 , appear to be regulated independently of c Cbl . ^^^ |
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