Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P21802 and P22681	Pubmed	SVM Score :0.0
Cbl mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor 2 activation supports osteoblast differentiation . ^^^ Immunoprecipitation studies showed that Lyn , Fyn , and FGFR 2 interacted with the ubiquitin ligase c Cbl and ubiquitin . ^^^ Transfection with c Cbl in which the RING finger was disrupted or with c Cbl with a point mutation that abolishes the binding ability of the Cbl phosphotyrosine binding domain restored Src kinase activity and Lyn , Fyn , and FGFR 2 levels and reduced ALP up regulation in mutant osteoblasts . ^^^ Thus , constitutive FGFR 2 activation induces c Cbl dependent Lyn and Fyn proteasome degradation , resulting in reduced Lyn and Fyn kinase activity , increased ALP expression , and FGFR 2 down regulation . ^^^ This reveals a common Cbl mediated negative feedback mechanism controlling Lyn , Fyn , and FGFR 2 degradation in response to overactive FGFR 2 and indicates a role for Cbl dependent down regulation of Lyn and Fyn in osteoblast differentiation induced by constitutive FGFR 2 activation . . ^^^
Interacting proteins: P21802 and P22681	Pubmed	SVM Score :0.0
Cbl mediated ubiquitination of alpha 5 integrin subunit mediates fibronectin dependent osteoblast detachment and apoptosis induced by FGFR 2 activation . ^^^ Immunocytochemistry revealed that alpha 5 integrin colocalizes with FGFR 2 and Cbl at the leading edge in membrane ruffle regions . ^^^ This suggests that Cbl mediated ubiquitination plays an essential role in alpha 5 integrin proteasome degradation induced by FGFR 2 activation . ^^^ We show that Cbl recruitment induced by FGFR 2 activation triggers alpha 5 integrin degradation by the proteasome , which results in reduced osteoblast attachment on fibronectin and caspase dependent apoptosis . ^^^ This identifies a functional role of the alpha 5 integrin subunit in the induction of apoptosis triggered by FGFR 2 activation in osteoblasts , and reveals that a Cbl dependent mechanism is involved in the coordinated regulation of cell apoptosis induced by alpha 5 integrin degradation . . ^^^