| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| We show that orthovanadate and PAO augmented the Fc gamma RI induced tyrosine phosphorylation of the adaptor protein CBL . ^^^ |
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| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| Differential interaction of Crkl with Cbl or C3G , Hef 1 , and gamma subunit immunoreceptor tyrosine based activation motif in signaling of myeloid high affinity Fc receptor for IgG ( Fc gamma RI ) . ^^^ To gain insight into the role of Crkl in myeloid ITAM signaling , we investigated Cbl Crkl and Crkl C3G interactions following Fc gamma RI aggregation in U937IF cells . ^^^ Fc gamma RI cross linking of U937IF cells results in the tyrosine phosphorylation of Cbl , Crkl , and Hef 1 , an increase in the association of Crkl with Cbl via direct SH 2 domain interaction and increased Crkl Hef 1 binding . ^^^ The induced association of Crkl with Cbl , Hef 1 , and Fc gamma RI gamma after Fc gamma RI activation and the constitutive association between C3G and Crkl provide the first evidence that a Fc gamma RI gamma Crkl C3G complex may link ITAM receptors to the activation of Rap 1 in myeloid cells . . ^^^ |
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| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages . ^^^ |
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| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12314 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|