| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.55120065 |
| In vitro and in vivo experiments support the hypothesis that Grb 2 mediates the association of c Kit with c Cbl . 0.55120065^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.54284941 |
| Apart from the direct association between Cbl and c Kit , we show that phosphorylation of Cbl by SFK members is required for activation of Cbl to occur . 0.54284941^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| We also provide evidence that c Cbl is not stably associated with the kit receptor either prior to or following KL stimulation . ^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| More recently it has been found that cbl is rapidly phosphorylated following stimulation of the EGF receptor , Fcy receptor , c Kit receptor and CSF 1 receptor . ^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c kit , phosphatidylinositol 3 kinase , and p 120 ( CBL ) . ^^^ We conclude that SF induces the formation of a signaling complex potentially containing CRKL and p 120 ( CBL ) , both of which bind to c Kit through p 85 ( PI3K ) . ^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| Moreover , CIN 85 and Cbl / Cbl b were constitutively associated with activated PDGF , EGF , or c Kit receptors in several tumor cell lines . ^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| Here , we show that stem cell factor ( SCF ) , the ligand for KIT , induces the interaction between KIT and Cbl proteins and their mutual degradation . ^^^ Upon SCF stimulation , KIT binds to and induces the phosphorylation of Cbl proteins , which in turn act as E 3 ligases , mediating the ubiquitination and degradation of KIT and themselves . ^^^ Tyrosine kinase binding and RING finger domains of Cbl are essential for Cbl mediated ubiquitination and degradation of KIT . ^^^ The activated KIT in turn induces phosphorylation and activation of Cbl proteins . ^^^ The Cbl proteins then bind and direct the degradation of activated KIT , leading to down regulation of KIT signaling . . ^^^ |
|
| Interacting proteins: P10721 and P22681 |
Pubmed |
SVM Score :0.0 |
| Interactions with SH 2 domain adapters [ growth factor receptor binding protein 2 ( Grb 2 ) , Cbl , Slp 76 ] and SH 3 domain adapters ( HS 1 , cortactin , CD2BP3 ) were attenuated by inhibition of Kit kinase activity . ^^^ |
|