| Interacting proteins: P09769 and P22681 |
Pubmed |
SVM Score :0.97963149 |
| Thus Cbl appears to be essential in beta ( 2 ) integrin signalling , first by serving as a matrix for a subsequent agonist induced signalling interaction between Fgr and Syk , and then by mediating ubiquitination of Fgr which possibly affects its interaction with Cbl . . 0.97963149^^^ |
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| Interacting proteins: P09769 and P22681 |
Pubmed |
SVM Score :0.0 |
| Following ligation of surface integrins by fibronectin , the p 120 ( c cbl ) ( Cbl ) protein rapidly becomes tyrosine phosphorylated and associated with the Src family kinases Fgr and Lyn . ^^^ In hck / fgr / lyn / triple mutant cells , which are defective in spreading on fibronectin coated surfaces in vitro and show impaired migration in vivo , Cbl tyrosine phosphorylation is blocked , Cbl protein levels are low , adhesion dependent translocation of Cbl to the membrane is impaired and Cbl associated , membrane localized phosphatidylinositol 3 ( PI 3 ) kinase activity is dramatically reduced . ^^^ |
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| Interacting proteins: P09769 and P22681 |
Pubmed |
SVM Score :0.0 |
| Indeed , CD 38 ligation on monocytes induces tyrosine phosphorylation of several intracellular proteins including the protooncogene product c cbl and the fgr and hck tyrosine kinases . ^^^ |
|
| Interacting proteins: P09769 and P22681 |
Pubmed |
SVM Score :0.0 |
| Instead , both PMA treated wild type and hck ( / ) fgr ( / ) macrophages were defective in spontaneous and chemotactic migration and tyrosine phosphorylation of the Cbl protooncoprotein was decreased in both . ^^^ Moreover , c cbl ( / ) macrophages displayed the same impairment of motility as hck ( / ) fgr ( / ) macrophages and a similar morphology with less polarization and more dorsal ruffling than wild type macrophages . ^^^ As Hck and Fgr expression and activity were not decreased in c cbl ( / ) macrophages , these results suggest that Cbl is likely to be an important downstream mediator of the Src family kinase regulated macrophage motility pathway . . ^^^ |
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