| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.95504259 |
| Kinetic analysis reveals that the tyrosine phosphorylation of Cbl is coincident with its plasma membrane translocation and association with the activated tyrosine phosphorylated CSF 1 R , p 85 , Grb 2 , and tyrosine phosphorylated p58Shc and that these events precede the simultaneous multiubiquitination of Cbl and the CSF 1 R . 0.95504259^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.67848468 |
| Association of Cbl with Fms and p 85 in response to macrophage colony stimulating factor . 0.67848468^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl associates directly with the C terminal tail of the receptor for the macrophage colony stimulating factor , c Fms , and down modulates this receptor but not the viral oncogene 5 Fms . ^^^ Here , we have identified c Cbl as the direct binding partner for c Fms . c Cbl binds to phosphotyrosine residue 977 at the C terminal end of feline c Fms , which is absent in 5 Fms . ^^^ Furthermore , the replacement of tyrosine 977 into phenylalanine in feline c Fms and vc Fms reduced the Cbl dependent ubiquitination . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| Treatment with M CSF results in further tyrosine phosphorylation of both p130Cas and c Cbl , suggesting cooperation between alpha 5 beta 3 integrin and the M CSF receptor , c Fms , in osteoclasts . ^^^ However , M CSF induces tyrosine phosphorylation of c Cbl , but not p130Cas in pOCs in suspension , confirming the role of c Cbl as a downstream effector of c Fms . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| A small pool of CSF 1R formed a multimeric complex with phosphatidylinositol 3 kinase ( PI 3 kinase ) , SHP 1 , Grb 2 , Shc , c Src , Cbl , and a significant number of tyrosine phosphorylated proteins in CSF 1 stimulated cells . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| Colony stimulating factor 1 ( CSF 1 ) activation of the CSF 1 receptor ( CSF 1R ) causes Cbl protooncoprotein tyrosine phosphorylation , Cbl CSF 1R association and their simultaneous multiubiquitination at the plasma membrane . ^^^ The CSF 1R is then rapidly internalized and degraded , whereas Cbl is deubiquitinated in the cytoplasm without being degraded . ^^^ Consistent with this result , Cbl / macrophage cell surface CSF 1 CSF 1R complexes are internalized more slowly , yet are still lysosomally degraded , and the CSF 1 utilization by Cbl / macrophages is reduced approximately 2 fold . ^^^ Thus , attenuation of proliferation by Cbl is associated with its positive regulation of the coordinated multiubiquitination and endocytosis of the activated CSF 1R , and a reduction in the time that the CSF 1R signals from the cell surface . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| This finding coincides with an increased CSF 1R ubiquitination and an enhanced accumulation of c Cbl . c Cbl is an ubiquitin ligase known to down regulate activated CSF 1R by targeting it to the endocytic pathway . ^^^ Our results indicate that upon CSF 1R activation , c Cbl itself is partly proteolytically degraded in ICSBP ( + / + ) but not in ICSBP ( / ) BMMs . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| Aberrant expression of HOXA 9 , DEK , CBL and CSF1R in acute myeloid leukemia . ^^^ Previous gene function analyses have indicated that HOXA 9 , DEK , CBL and CSF1R are aberrantly expressed in acute myeloid leukemia ( AML ) . ^^^ DEK was overexpressed in 98 % of the cases , whereas CBL , CSF1R and HOXA 9 were either overexpressed in 20 % , 17 % and 78 % or underexpressed in 20 % , 42 % and 15 % of the cases , respectively . ^^^ Furthermore , an association was found between the AML M 2 subtype and lower expression of CBL , CSF1R or HOXA 9 , and between the AML M 5 subtype and CBL or CSF1R overexpression . . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| Consistent with a defect in receptor negative regulation , c Cbl tyrosine phosphorylation and CSF 1R / c Cbl co association were almost undetectable in the Y559F mutant . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| The 100 kDa protein did not appear to bind directly to Fms , Ship , Cbl , Shc , or Grb 2 , although all of these proteins were coimmunoprecipitated with p 85 after M CSF stimulation . ^^^ |
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| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07333 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|