| Interacting proteins: O94875 and P22681 |
Pubmed |
SVM Score :0.91206393 |
| We found that Pyk 2 and Cbl interacted with the adaptor protein ArgBP 2 , which also bound to flotillin 1 , a component of lipid raft microdomains . 0.91206393^^^ |
|
| Interacting proteins: O94875 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl ArgBP 2 complex mediates ubiquitination and degradation of c Abl . ^^^ We found that the multi adaptor protein ArgBP 2 links c Abl to the ubiquitin ligase Cbl . ^^^ Phosphorylation of Cbl and ArgBP 2 by c Abl resulted in the stabilization of their interactions , thus facilitating Cbl induced ubiquitination and subsequent degradation of c Abl and ArgBP2 . . ^^^ |
|
| Interacting proteins: O94875 and P22681 |
Pubmed |
SVM Score :0.0 |
| ArgBP 2 , and its brain specific splice variant , nArgBP 2 , are interactors and substrates of Abl / Arg tyrosine kinases and of the ubiquitin ligase Cbl . ^^^ |
|
| Interacting proteins: O94875 and P22681 |
Pubmed |
SVM Score :0.0 |
| ArgBP 2 is directly linked to intracellular signaling cascades by its interaction with Abl family kinases , Pyk 2 and the ubiquitin ligase Cbl . ^^^ |
|
| Interacting proteins: O94875 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|