| Such translocation temporally matches the insulin stimulated movement of Cbl and CrkII in flotillin 1 / GLUT4 containing domains , as well as the activation of the GDP GTP exchange factor C3G . ^^^ Thus , the activation of the Cbl / C3G / TC10 dependent pathway , which occurs before flotillin 1 / GLUT4 containing domains reach the plasma membrane , is flotillin 1 mediated and follows the activation of the PI3K mediated signaling . ^^^ |