| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| CD 16 mediated activation of phosphatidylinositol 3 kinase ( PI 3K ) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb 2 , Shc , pp 36 and p 85 PI 3K subunit . ^^^ Overall these results suggest that the formation of a complex containing either Shc or pp 36 associated with Grb 2 , Cbl and the p 85 subunit of Pl 3K is one of the major mechanisms which might couple CD 16 to the Pl 3K pathway in NK cells . . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| In addition to Zap 70 , the 3BP2 SH 2 domain associated in vitro with LAT , Grb 2 , PLCgamma 1 , and Cbl from activated T cell lysates . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| Perturbed regulation of ZAP 70 and sustained tyrosine phosphorylation of LAT and SLP 76 in c Cbl deficient thymocytes . ^^^ At this time , ZAP 70 from both normal and c Cbl / thymocytes becomes hyperphosphorylated ; however , only in normal thymocytes does this correlate with ZAP 70 down regulation and a diminished ability to phosphorylate LAT and SLP 76 . ^^^ In contrast , c Cbl deficient thymocytes display altered phosphorylation kinetics , for which LAT phosphorylation is increased and SLP 76 phosphorylation is sustained . ^^^ These findings provide evidence that c Cbl is involved in the negative regulation of the phosphorylation of LAT and SLP 76 by ZAP 70 . . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| Some adapter proteins , such as SLP 76 , Vav , and LAT , positively regulate TCR mediated signal transduction , whereas others , such as Cbl , play an inhibitory role . ^^^ |
|
| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| Moreover , although P gp ( low ) cells frequently recruited both c Cbl and LAT to the APC synapse , cells in the less responsive P gp ( high ) subset frequently relocated c Cbl , but not LAT , to the interface region . ^^^ In some systems , c Cbl can act as a negative regulator of receptor dependent tyrosine kinases , and alterations of c Cbl to LAT ratios in the P gp ( high ) subset may thus contribute to the hyporesponsiveness of this age dependent , anergic memory cell population . . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| The transmembrane adapter LAT coprecipitates with SLP 76 and PLCgamma 2 , as well as with a number of other adapter proteins , some of which have not been previously described in platelets , including Cbl , Grb 2 , Gads , and SKAP HOM . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| CD 2 crosslinking markedly induced tyrosine phosphorylation of Cbl associated with Grb 2 or CrkL , Shc and LAT , compared with IL 2 stimulation . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| Z / 3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat and Slp 76 independent signaling mechanism . ^^^ The complete elimination of PLC gamma 1 phosphorylation required deleting the SH 3 domain binding region of 70Z / 3 Cbl , consistent with 70Z / 3 Cbl binding the PLC gamma 1 SH 3 domain . 70Z / 3 Cbl induced PLC gamma 1 phosphorylation required Zap 70 , as for the TCR , and the tyrosine kinase binding domain of 70Z / 3 Cbl , which binds Zap 70 , but did not require PLC gamma 1 binding to Lat , a crucial interaction in TCR induced PLC gamma 1 phosphorylation . ^^^ These results suggest that 70Z / 3 Cbl and PLC gamma 1 form a TCR , Lat and Slp 76 independent complex that leads to PLC gamma 1 phosphorylation and activation . . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| The activated kinases then in turn phosphorylate and activate other enzymes [ phospholipase Cgamma ( PLCgamma ) isoforms , phosphatidylinositol 3 kinase ( PI3K ) isoforms , protein kinase C ( PKC ) isoforms , Bruton ' s tyrosine kinase ( Btk ) and others ] , adaptors [ linker for activation of T cells ( LAT ) , Cbl , Grb 2 and others ] and GTP exchange factors / GTPases ( Vav , Ras , Rho , and others ) , and subsequently induce the mobilization of stored and extracellular Ca ( 2+ ) . ^^^ |
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| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| In T cells , the SH 2 domain of GRB 2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB 2 SH3 domains associate with the proline rich regions of SOS 1 and CBL . ^^^ |
|
| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43561 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|