| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| In this paper we report the production of monoclonal antibodies against both alpha and beta catenin and use these antibodies to show that in cells simultaneously expressing two different cadherins , E cadherin and P cadherin , each cadherin appears to be present in a separate cadherin / catenin complex . . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used conventional epifluorescence microscopy to examine P cadherin immunoreactivity in cryostat sections of mouse testis and scanning laser confocal microscopy to localize P cadherin and beta catenin in wholemount preparations of mouse seminiferous tubules . ^^^ In contrast , peritubular cells did not express P cadherin on postnatal day 8 and continued expression in adulthood . beta Catenin was localized near contact areas between peritubular cells on postnatal days 12 and 15 . ^^^ A mature pattern of actin filament organization in peritubular cells appeared on day 15 and coincided with the uniform appearance of P cadherin and beta catenin near areas of contact between adjacent peritubular cells . ^^^ The expression of P cadherin in peritubular cells is correlated temporally with the expression of beta catenin and the development of a mature network of actin filaments and is consistent with a role in intercellular adhesion and junction formation . . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| The adherens junction is composed of a transmembrane classical cadherin ( E cadherin and / or P cadherin in squamous epithelial cells ) linked to either beta catenin or plakoglobin , which is linked to alpha catenin , which is linked to the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| In the basal layer , patches of brightly labeled cells were detected with antibodies to E cadherin , beta catenin , and gamma catenin , but not with antibodies to P cadherin , alpha catenin , or with pan desmocollin and pan desmoglein antibodies . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| For example , AJs contain E , N , or P cadherin in combination with alpha and beta catenin , vinculin and alpha actinin , whereas in desmosomes , desmogleins and desmocollins are associated with desmoplakin and one or several of the plakophilins ( PP 1 3 ) . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Two types of E cadherin complexes , containing beta catenin or plakoglobin and alpha catenin , were detected in PDV cells as in other cell types , while P cadherin was mainly detected in complexes containing beta catenin and alpha catenin in PDV and other murine epidermal keratinocytes . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| METHODS : The authors examined the expression of P cadherin , E cadherin , and N cadherin , and alpha catenin and beta catenin in 183 cases of invasive breast carcinoma by immunohistochemistry on paraffin sections using specific antibodies and a steam based antigen retrieval method . ^^^ P cadherin expression is a better indicator of clinical outcome than alterations in the expression of E cadherin , N cadherin , alpha catenin , or beta catenin . . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In retinoblastoma and normal retina N cadherin associated with alpha catenin and beta catenin but not E or P cadherin . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| AIMS : ( 1 ) To investigate the role of P cadherin in colonic polyp formation . ( 2 ) To ascertain whether expression of P cadherin is independent of or correlated with expression of its associated proteins E cadherin , beta catenin , and gamma catenin . ( 3 ) To determine if P cadherin is functional regarding catenin binding in polyps . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : In general , P cadherin was expressed at a lower frequency compared to E cadherin , alpha , and beta catenin . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Correlation of P cadherin and beta catenin expression and phosphorylation with carcinogenesis in rat tongue cancer induced with 4 nitroquinoline 1 oxide . ^^^ Using biochemical and immunohistochemical techniques , we have investigated P cadherin , beta catenin , c src and c met protein expression , and phosphorylation of beta catenin in a rat model of tongue cancer induced with 4 nitroquinoline 1 oxide . ^^^ In controls , P cadherin and beta catenin were expressed only in cell membranes of tongue suprabasal epithelial cells , whereas strong reaction to P cadherin antibody was observed during carcinogenesis , especially in nests of cancer cells . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies demonstrated that P cadherin was capable of interacting with beta catenin in these normal and malignant tissues and cells . ^^^ Collectively , these findings suggest that the regulated expression of P cadherin / beta catenin complexes in ovarian tumor cells may represent a key step in disease progression . . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| To investigate the expression and distribution of cell adhesion molecules in chordomas , we immunohistochemically studied the expression of representative cell adhesion molecules , E cadherin , P cadherin , N cadherin , beta catenin , CD 44 , ICAM 1 ( CD 54 ) , NCAM ( CD 56 ) , and VCAM 1 ( CD 106 ) in 16 tumors from 16 patients ( skull base , n=5 ; cervical , n=2 ; sacral , n=9 ) and 3 cases of fetal notochord . ^^^ Of 16 tumors , 12 ( 75 . 0 % ) expressed membranous immunoreactivity for NCAM , 10 ( 62 . 5 % ) for VCAM 1 , 9 ( 56 . 3 % ) for CD 44 , 8 ( 50 . 0 % ) for N cadherin , 6 ( 37 . 5 % ) for beta catenin , 4 ( 25 % ) for ICAM 1 , and 1 ( 6 . 3 % ) for P cadherin . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Furthermore , grade 4D invasive cell lines ( HOC 313 and TSU ) expressing S100A4 mRNA did not express E cadherin , P cadherin , and beta catenin , while gamma catenin protein was only weakly expressed . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Importance of P cadherin , beta catenin , and Wnt5a / frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma . ^^^ EXPERIMENTAL DESIGN : The immunohistochemical expression of E cadherin , N cadherin , P cadherin , beta catenin , and Wnt5a / Frizzled was examined using tissue microarrays of 312 melanocytic tumors . ^^^ CONCLUSIONS : Alterations in the expression and subcellular localization of cell adhesion markers are important in the development and progression of melanocytic tumors , and strong cytoplasmic P cadherin expression and loss of nuclear beta catenin staining were associated with aggressive melanoma behavior and reduced patient survival . . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| Other markers of importance include carcinoembryonic antigen ( CEA ) , B catenin , placental cadherin ( P cadherin ) , epithelial cadherin ( E cadherin ) , inducible nitric oxide synthase ( iNOS ) , cyclooxygenase ( COX 2 ) and P16INK4a . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| The immunohistochemical expressions of carcinoembryonic antigen ( CEA ) , beta catenin , placental cadherin ( P cadherin ) , epithelial cadherin ( E cadherin ) , inducible nitric oxide synthase ( iNOS ) , cyclooxygenase ( COX 2 ) , and P16INK4a are found to be altered . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| The small molecular ILK inhibitor MC 5 blocked puromycin induced nuclear translocation of beta catenin , podocyte detachment , cell proliferation , and repression of the slit membrane molecules P cadherin and CD2ap . ^^^ |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22223 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|