| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.86165303 |
| We then analyzed the interactions of tissue transglutaminase ( tTGase ) , a Ca2+ dependent enzyme , with RhoA and Rac 1 on the GST fusion protein arrays with the SPR biosensor . 0.86165303^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Tissue transglutaminase ( tTG ) expression was found to be induced in rat liver following in vivo retinoic acid ( RA ) treatment ( Piacentini et al . ( 1988 ) Biochem . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| In certain cell types , investigators have previously observed a specific and early effect of RA on transcriptional activation of the gene for tissue transglutaminase ( tTG ) , an enzyme suspected to play a role in apoptosis . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Dibutyryl cyclic AMP potentiated the RA induced expression of tissue transglutaminase . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Retinoic acid ( RA ) induces tissue transglutaminase ( TGASE ) and inhibits terminal differentiation induced either by calcium ion or by the tumor promoter 12 O tetradecanoylphorbol 13 acetate ( TPA ) in primary mouse epidermal cells in culture . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Two enzymes , NAD glycohydrolase and tissue transglutaminase , that are abundant in macrophages , were induced by RA but not by NAm . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| We studied tissue transglutaminase ( TGase ) expression in human myelomonocytic leukemia cells treated by combinations of all trans retinoic acid ( RA ) and 1 , 25 dihydroxyvitamin D 3 ( VD ) . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that all trans retinoic acid ( RA ) is a potent inducer of tissue transglutaminase ( TGase 2 ) and apoptosis in the rat tracheobronchial epithelial cell line SPOC 1 . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| From the functional point of view , exposure of LC 8 cells to 3 10 10 ( 6 ) M all trans retinoic acid ( RA ) caused a 75 fold induction in tissue transglutaminase and an approximately 9 fold induction in 10 ( 6 ) M RA at three days of culture . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| RA synovium ( compared with that of patients with OA or joint trauma ) had increased numbers of macrophages and increased expression / content of fibrinogen , tissue factor , factor 13 , tissue transglutaminase , cross linked fibrin ( fibrin D dimer ) , urokinase type plasminogen activator , and alpha 2 plasmin inhibitor . ^^^ Factor 13 and tissue transglutaminase were present in scant amounts in trauma and OA synovia , but there were increased amounts of both ( especially tissue transglutaminase ) in RA synovium in the vessel , lining cell , and interstitial cell areas . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| The addition of retinoic acid ( RA , 50 nM ) to Dulbecco ' s modifed Eagle ' s medium containing 1 . 0 percent bovine serum albumin and 50 mu g / l of gentamicin markedly increased the activity of a Ca ( 2+ ) dependent tissue transglutaminase ( TGase ) ( ca . 3 . 2 fold ) , which stabilizes newly formed protein assemblies at the sites of synapses , in isolated rat superior cervical sympathetic ganglia ( SCG ) , which is abundant in synapses , following in vitro aerobic incubation for 3 h at 37 degrees C . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Thus , induction of tissue transglutaminase by all trans RA and , surprisingly , 9 cis RA was enhanced 5 fold over and above the level of induction in control cells ( SC 115 ) , and activation of a RA response element reporter was enhanced 3 fold ( MDA MB 231 ) . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Also , the expression of RA and T 3 target genes , tissue transglutaminase ( tTG ) and neurogranin ( RC 3 ) , was measured in the whole brain and in the hippocampus of mice . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| We treated primary epithelial cells from human normal prostate ( NEPC ) and prostate cancer ( CEPC ) with all trans retinoic acid ( RA ) to study whether it regulates the activity of tissue transglutaminase ( tTGase ) , an enzyme that accumulates in cells undergoing apoptosis . tTGase activity was assessed by [ 14C ] spermidine incorporation ; tTGase , P 53 , Bcl 2 , and p 21 protein levels were evaluated by Western blotting ; and RA receptors ( RAR alpha , beta , and gamma ) , tTGase , retinol binding protein ( RBP ) , and cellular RBP type 1 transcripts were determined by semiquantitative RT PCR . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| The expression of tissue transglutaminase ( tTG ) , an enzyme proposed to play a role in apoptosis was induced with RA , as shown by both enzymatic assay and in situ immunofluorescence detection . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| When RA was used in combination with 2 mM NaB , the treatment induced substantial morphological changes , apoptosis independent growth arrest , up regulation of tissue transglutaminase ( tTGase ) , and down regulation of beta and gamma RA receptor ( RAR ) mRNA expression . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| In attempting to discover the underlying biochemical activities that might account for these cellular effects , we found that monodansylcadaverine ( MDC ) , which binds to the enzyme ( transamidase ) active site of tissue transglutaminase ( TGase ) , eliminated RA protection against cell death and in fact caused RA to become an apoptotic factor , suggesting that the ability of RA to protect against apoptosis is linked to the expression of active TGase . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Tissue transglutaminase mediates activation of RhoA and MAP kinase pathways during retinoic acid induced neuronal differentiation of SH SY5Y cells . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Retinoic acid ( RA ) is a potent activator of tissue transglutaminase ( TGase ) expression , and it was recently shown that phosphoinositide 3 kinase ( PI3K ) activity was required for RA to increase TGase protein levels . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| In parallel , there was a marked increase in the expression of two RA regulated genes , cellular retinoic acid binding protein 2 and tissue transglutaminase . ^^^ In the premenopausal endometrium , the levels of RALDH 1 , RALDH 2 , RAR alpha , and cellular retinoic acid binding protein 2 were increased in the estrogen dominated proliferative phase , and the transcripts for the RA catabolic enzyme retinoic acid 4 hydroxylase ( CYP26A1 ) and tissue transglutaminase were significantly increased in the secretory phase . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Using an in vitro cell culture model of neuroblastoma SH SY5Y cells , we demonstrated previously that RhoA is an in vivo substrate of tissue transglutaminase ( TGase ) and retinoic acid ( RA ) promoted activation of RhoA by transamidation . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| RA induces expression of tissue transglutaminase ( TGase ) and promotes migration and invasion after 24 h of treatment in SH SY5Y cells , but not in IMR 32 cells . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Retinoic acid ( RA ) addition to 5 day old cultured monocytes , 36 h later induced about 5 folds increase of TGc content . ^^^ The preliminary exposure of cultured monocytes to alpha difluoromethylornithine ( DFMO ) significantly reduced TGc induction caused by RA . ^^^ The supplementation of putrescine ( 1 mM ) or spermidine ( 0 . 5 mM ) to culture medium reversed the inhibiting effect of DFMO on RA mediated induction of TGc . ^^^ However , the addition of polyamines in the absence of RA or DFMO did not mimic the induction of TGc by RA . ^^^ We conclude that TGc induction by RA during in vitro maturation of monocytes to macrophages may be modulated by polyamine availability . . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| The transglutaminase 2 mRNA level and activity were increased by RA injection at 4 h and 8 h after PH , respectively . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Chemopreventive retinoids may be more effective if delivered to the lung epithelium by inhalation . 13 cis Retinoic acid ( 13 cis RA ) was comparable to all trans retinoic acid ( RA ) in inducing transglutaminase 2 ( TGase 2 ) in cultured human cells . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Role of transglutaminase 2 in retinoic acid induced activation of RhoA associated kinase 2 . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| In BEAS 2B R 1 cells , RA dysregulated the expression of the putative lymphocyte G0 / G1 switch gene ( G0S2 ) , heme oxygenase 1 ( HMOX 1 ) , tumor necrosis factor alpha induced protein 2 ( TNFAIP 2 ) , inhibitor of DNA binding 1 ( Id 1 ) , fos like antigen 1 ( FOSL 1 ) , transglutaminase 2 ( TGM 2 ) , asparagine synthetase ( ASNS ) , PLAB , PAOh 1 and ELF 3 , while prominent induction of insulin like growth factor binding protein 6 ( IGFBP 6 ) still occurred . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Immunoblotting was used to assess induction of the RARbeta , placental transforming growth factor beta ( PTGF beta ) , Fos related antigen 1 ( Fra 1 ) , and transglutaminase 2 ( TGase 2 ) proteins by RA following treatment with azacitidine , a DNA demethylating agent . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| Treatment with retinoic acid ( RA ) , an inducer of TG 2 expression , significantly decreased EGF induced DNA synthesis in both PPH and PVH . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| A dramatic increase of TG 2 expression and activation is induced by retinoic acid ( RA ) . ^^^ Here we show the effect of the RA induced overexpression of TG 2 on liver regeneration after PH . ^^^ The treatment of RA greatly increased TG 2 activity at 1 day after PH . ^^^ |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21980 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|