Our analysis also indicates that TAF 5 , TAF 6 , TAF 9 , and TAF 12 play key roles in stability of the complex , whereas TBP , TAF 1 , TAF 2 , and TAF 11 contribute very little to complex stability . ^^^ Based on our results , we propose that holo TFIID comprises a stable core subcomplex containing TAF 4 , TAF 5 , TAF 6 , TAF 9 , and TAF 12 decorated with peripheral subunits TAF 1 , TAF 2 , TAF 11 , and TBP . ^^^ In contrast to both TAF 1 and TAF 4 , RNAi knockdown of TAF 5 had little effect on transcription from either class of promoter . ^^^ |