| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| While colony forming unit erythroid ( CFU E ) and burst forming unit erythroid ( BFU E ) colonies were not present in cultures derived from EpoR / liver or yolk sac cells , hemoglobin containing BFU E colonies were detected in cultures treated with recombinant Tpo and Kit ligand or with Tpo and interleukin 3 and 11 . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| As with EPO R studies , examination of IL 3 and SCF receptors on PV erythroid cells has not identified mechanisms underlying the observed increased sensitivities to these hematopoietic growth factors . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Here we show that erythroid progenitors from erythropoietin receptor ( Epo R ) / fetal livers , infected in vitro with a retrovirus expressing the wild type Epo R , require addition of both Epo and stem cell factor ( SCF ) to form colony forming unit erythroid ( CFU E ) colonies . ^^^ However , only Epo R F7Y479 is capable of supporting erythroid colony formation when expressed in ( Epo R ) / fetal liver cells , indicating that Y 464 either can not send a differentiation signal or fails to respond to SCF / KIT activation . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| F . ( 1995 ) Nature 377 , 242 246 ) documents the interaction of the erythropoietin ( EPO ) receptor ( EPOR ) with the stem cell factor ( SCF ) receptor ( c KIT ) and suggests that SCF acts through the EPOR . ^^^ To elucidate the ability of SCF to affect the erythropoietin signaling pathway , we studied the effect of SCF on EPOR phosphorylation , SHC / ERK 1 activity , and cell proliferation and apoptosis in EPO dependent HCD 57 cells . ^^^ Treatment of these cells with SCF resulted in phosphorylation of the EPOR . ^^^ However , SCF dependent phosphorylation of the EPOR did not initiate an EPO like intracellular signal . ^^^ SCF stimulated SHC phosphorylation and ERK 1 activation independent of the EPOR in cells where the EPOR was down regulated ; the presence of the EPOR appeared to facilitate SCF activation of SHC and ERK 1 . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Bone marrow derived stromal cells expressing only a membrane restricted ( MR ) isoform of SCF induced an elevated and sustained tyrosine phosphorylation of both c kit and erythropoietin receptor ( EPO R ) and significantly greater proliferation of an erythrocytic progenitor cell line compared with stromal cells expressing soluble SCF . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| In the erythroleukemia cell line TF 1 , recombinant human erythropoietin ( rHEpo ) , but not c kit ligand , enhanced the number of cells expressing the erythropoietin receptor ( EpoR ) , as measured by flow cytometric analysis of binding of the biotin labeled Epo . ^^^ Moreover , 125I Epo binding and Scatchard analyses , indicated that TF 1 cells , maintained in standard conditions with IL 3 , and those stimulated with c kit ligand , bear a single class of EpoR . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| While the levels of expression of several genes involved in erythropoiesis ( GATA 1 , NF E 2 , SCL , and EpoR ) were reduced in the livers of homozygous mutant fetuses in comparison to phenotypically normal littermates and one gene , Kit ligand ( KL ) , was expressed at higher levels in the mutant livers , these results must be viewed with caution . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| In Kit+ CD71+ erythroblasts , EpoR PY 343 signals furthermore enhanced SCF growth effects , and SCF modulation of Pim 1 kinase and oncostatin M expression . ^^^ Stress erythropoiesis , therefore , requires stage specific EpoR PY 343 Stat5 signals , some of which selectively bolster SCF and oncostatin M action . . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Here we show that chimeric receptors carrying the extracellular domain of the epidermal growth factor receptor or c kit linked to the cytoplasmic domain of the EPOR , transmitted epidermal growth factor or stem cell factor dependent proliferation signals in an interleukin 3 dependent cell line . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| The GrapSH 2 domain interacts with ligand activated receptors for stem cell factor ( c kit ) and erythropoietin ( EpoR ) . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Induction of the erythropoietin receptor gene and acquisition of responsiveness to erythropoietin by stem cell factor in HML / SE , a human leukemic cell line . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| A synergistic interaction between EpoR and c kit is essential for the production of normal numbers of red blood cells , as demonstrated by the severe anemia of mice mutant for either c kit or its ligand , stem cell factor . ^^^ We show that the addition of stem cell factor potentiates the ability of the PrlR to support differentiation of both EpoR / and wild type CFU e progenitors . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| EPO dependent tyrosine phosphorylation of Stat 5 also increased , but the EPO receptor ( EPO R ) expression remained unchanged in the CD34+ / CD45+ cells treated with SCF + HGF . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Here we examined the role of EPOR in erythropoiesis stimulated by SCF , sIL 6R , and IL 6 . ^^^ Surprisingly , reduction of EPOR expression using antisense oligodeoxynucleotides suppressed erythropoiesis stimulated not only by SCF and EPO , but also by SCF , sIL 6R , and IL 6 . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| METHODS : Purified 1 10 10 ( 4 ) circulating CD34+ cells isolated from rHuEPO hyporesponsive HD patients ( EPO H ; n = 10 ) , rHuEPO responsive non HD patients with CRF ( EPO R ; n = 8 ) , nonanemic HD patients without rHuEPO therapy ( EPO W / O ; n = 10 ) , and healthy volunteer controls ( CON ; n = 10 ) were subjected to a methylcellulose culture system supplemented with rHuEPO , recombinant human interleukin 3 ( IL 3 ) , recombinant human stem cell factor ( SCF ) , and recombinant human granulocyte macrophage colony stimulating factor ( GM CSF ) for 14 days . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Here we describe a second , distinct type of erythroid progenitor ( EpoR progenitors ) which can be established from freshly isolated bone marrow and is induced to self renew by ligands relevant for erythropoiesis , i . e . erythropoietin , stem cell factor , the ligand for c Kit and the glucocorticoid receptor ligand dexamethasone . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Stem cell factor significantly enhanced both EPO R expression and in vitro response to EPO . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Stem cell factor induces the expression of Stat 5 and erythropoietin receptor , resulting in efficient proliferation and survival by erythropoietin . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| Erythropoiesis is severely impaired in mice with inactivating mutations in the Steel factor ( SF ) gene ( Sl / Sl mice ) or in c kit , in the SF receptor gene ( W / W mice ) , and in mice with null mutations in the genes for either erythropoietin ( EPO ) or the erythropoietin receptor ( EPO R ) . ^^^ These results indicate that EPO / EPO R can function to support colony formation in the absence of an SF signal . . ^^^ |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21583 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|