| Interacting proteins: Q99584 and P21579 |
Pubmed |
SVM Score :0.0 |
| S100A13 is involved in the regulation of fibroblast growth factor 1 and p 40 synaptotagmin 1 release in vitro . ^^^ |
|
| Interacting proteins: Q99584 and P21579 |
Pubmed |
SVM Score :0.0 |
| Although biochemical evidence suggests that the formation of a multiprotein complex containing S100A13 and Synaptotagmin ( Syt ) 1 is important for the release of FGF 1 , it is unclear where this intracellular complex is assembled . ^^^ As a result , we employed real time analysis using confocal fluorescence microscopy to study the spatio temporal aspects of this nonclassical export pathway and demonstrate that heat shock stimulates the redistribution of FGF 1 from a diffuse cytosolic pattern to a locale near the inner surface of the plasma membrane where it colocalized with S100A13 and Syt 1 . ^^^ In addition , coexpression of dominant negative mutant forms of S100A13 and Syt 1 , which both repress the release of FGF 1 , failed to inhibit the stress induced peripheral redistribution of intracellular FGF 1 . ^^^ |
|
| Interacting proteins: Q99584 and P21579 |
Pubmed |
SVM Score :0.0 |
| Human acidic fibroblast growth factor ( hFGF 1 ) is a potent mitogen and is involved in the regulation of key cellular process such as angiogenesis , differentiation , and morphogenesis . hFGF 1 is a signal peptide less protein that is released into the extracellular compartment as a multiprotein complex consisting of S100A13 , synaptotagmin ( Syt 1 ) , and a hFGF 1 homodimer . ^^^ |
|
| Interacting proteins: Q99584 and P21579 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor ( FGF ) 1 is released from cells as a constituent of a complex that contains the small calcium binding protein S100A13 , and the p 40 kDa form of synaptotagmin ( Syt ) 1 , through an ER Golgi independent stress induced pathway . ^^^ |
|