| Interacting proteins: Q86UR5 and P21579 |
Pubmed |
SVM Score :0.0 |
| In particular , insight into how Munc 18 1 collaborates with SNARE proteins in fusion , how the vesicular Ca2+ sensor synaptotagmin 1 triggers fast release , and how the vesicular Rab 3 protein regulates release by binding to the active zone proteins RIM 1 alpha and RIM 2 alpha has advanced our understanding of neurotransmitter release . ^^^ |
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| Interacting proteins: Q86UR5 and P21579 |
Pubmed |
SVM Score :0.0 |
| We found that the two C ( 2 ) domains of RIM display properties analogous to those of the C ( 2 ) B domain of synaptotagmin 1 . ^^^ In addition , the C ( 2 ) domains of RIM associate with SNAP 25 and synaptotagmin 1 . ^^^ The interactions of the C ( 2 ) domains of RIM with SNAP 25 and synaptotagmin 1 are modulated by Ca ( 2+ ) . ^^^ Synaptotagmin 1 binding is abolished by mutations in two positively charged amino acids in the C ( 2 ) domains of RIM and by the addition of inositol polyphosphates . ^^^ |
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| Interacting proteins: Q86UR5 and P21579 |
Pubmed |
SVM Score :0.0 |
| The RIM C2A domain does not contain the full complement of aspartate residues that commonly mediate Ca2+ binding at the top loops of C 2 domains , and has been reported to interact with SNAP 25 and synaptotagmin 1 , two proteins from the Ca2+ dependent membrane fusion machinery . ^^^ Moreover , little binding of the RIM 2 C2A domain to SNAP 25 and to the C 2 domains of synaptotagmin 1 was detected by NMR experiments , suggesting that as yet unidentified interactions of the RIM C2A domain mediate its function . ^^^ |
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