| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| To understand better the biochemical mechanism of neurotransmitter release , we have investigated the calcium dependent and independent protein protein interactions between synaptotagmin 1 and syntaxin 1a , a subunit of the receptor for synaptic vesicles on the presynaptic plasma membrane . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization using isoform specific oligonucleotide probes to different exocytotic protein messenger RNAs ( mRNAs ) showed strong hybridization signal for synaptotagmin 1 , cysteine string protein ( CSP ) , VAMP 2 ( vesicle associated membrane protein ) , cellubrevin , munc 18 ( mammalian homologue of unc 18 ) , SNAP 25a ( synaptosomal associated protein of 25 kDa ) , syntaxin 1A , syntaxin 4 , syntaxin 5 , and alpha SNAP ( soluble NSF attachment protein ) in the anterior and intermediate , but not in the posterior lobe of the pituitary . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| The effects of these mutations on synaptotagmin 1 C2A function were analyzed for ( 1 ) calcium dependent phospholipid binding , ( 2 ) calcium dependent binding to syntaxin 1A , a plasma membrane protein critical for vesicle docking or fusion , and ( 3 ) calcium regulated secretion after microinjection into neuroendocrine pheochromocytoma ( PC 12 ) cells . ^^^ The synaptotagmin 1 C2A polylysine motif functions independently of calcium mediated interactions with phospholipids and syntaxin 1A . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| Chronic haloperidol treatment caused significant decreases in the levels of synaptotagmin 1 and 4 , synaptobrevin 2 , syntaxin 1A and Rab 3A mRNAs in the nucleus accumbens but not in the prefrontal cortex medial field , striatum , substantia nigra and ventral tegmental area . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| The biochemical consequences of SNARE protein phosphorylation included a reduced interaction between SNAP 25 and phosphorylated syntaxin 4 and an enhanced interaction between phosphorylated syntaxin 1A and the synaptic vesicle protein synaptotagmin 1 , a potential Ca2+ sensor in triggering synaptic vesicle exocytosis . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| In contrast , immunostaining for the rest of the synaptic proteins analysed ( syntaxin 1A and 1B , synaptobrevin 1 and 2 , Rab3A , synaptophysin , synapsin 1 , synaptotagmin 1 and GAP 43 ) was virtually absent in neuronal cell bodies in treated animals . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| METHODS : Levels of mRNAs encoding four synaptic vesicle proteins ( synaptotagmin 1 [ p 65 ] , rab3a , synaptobrevin 1 , and synaptobrevin 2 ) and two synaptic plasma membrane proteins ( syntaxin 1A and SNAP 25 ) were measured postmortem in the left superior temporal gyrus from elderly ( 58 95 years ) schizophrenic patients ( n = 14 ) and age matched control subjects ( n = 9 ) . ^^^ RESULTS : There were significant negative correlations between age and levels of synaptotagmin 1 ( p 65 ) , rab3a , synaptobrevin 1 , SNAP 25 , and syntaxin 1A mRNAs in schizophrenic patients ( . 692 < r < . 517 , . 003 < p < . 030 ) but not in control subjects . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| The roles of SNARE proteins , i . e . neuronal Synaptobrevin ( n Syb ) , SNAP 25 and Syntaxin 1A ( Syx 1A ) , and Synaptotagmin 1 ( Syt 1 ) in synaptic transmission have been studied in situ using mutant embryos or larvae that lack these molecules or have alterations in them . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| Syntaxin 1A and synaptotagmin 1 are key participants of fusion complex formation during exocytotic processes , and syntaxin 1A is known to be present in the plasma membrane . ^^^ Here , we show the presence of not only synaptotagmin 1 but also syntaxin 1A in secretory granules of bovine adrenal chromaffin cells by immunogold electron microscopy , and further demonstrate the interaction of these proteins with chromogranins A and B ( CGA and CGB ) , two major proteins of secretory granules . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| Syt 1 and Syt 1 * harboring the mutation at the KKKK motif modified channel activation , while Syt 1 * only partially reversed the syntaxin 1A effects on channel activity . ^^^ |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q16623 |
Pubmed |
SVM Score :0.0 |
| NA |
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