Either a dominant negative RalA construct or the RalA binding domain of filamin 1 specifically block Cdc 42 induced filopod formation , but a Cdc 42 inhibitor does not impair RalA ' s effects , which , unlike Cdc 42 , are Rac independent . ^^^ RalA does not generate filopodia in filamin deficient human melanoma cells , whereas transfection of filamin 1 restores the functional response . ^^^ |