| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Pleiotrophin signaling through anaplastic lymphoma kinase is rate limiting for glioblastoma growth . ^^^ We have recently identified anaplastic lymphoma kinase ( ALK ) as a tyrosine kinase receptor for pleiotrophin , a secreted growth factor that is highly expressed during embryonic brain development and in tumors of the central nervous system . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Anti apoptotic signaling of pleiotrophin through its receptor , anaplastic lymphoma kinase . ^^^ The secreted growth factor pleiotrophin ( PTN ) can induce mitogenesis in cells that express the receptor for this growth factor , anaplastic lymphoma kinase ( ALK ) . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| MK binds to anaplastic lymphoma kinase ( ALK ) , the receptor for PTN , with an apparent K ( d ) of 170 pm in intact cells , and this receptor binding of MK is competed by PTN with an apparent K ( d ) of approximately 20 pm . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| In vitro , HARP was found to be mitogenic on human mammary epithelial and myoepithelial cell lines and correlated with the expression of its high affinity receptor tyrosine kinase ALK ( anaplastic lymphoma kinase ) . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| The mRNA transcripts of PTN and its receptors [ receptor protein tyrosine phosphatase ( RPTP ) beta / zeta , N syndecan and anaplastic lymphoma kinase ( ALK ) ] were detected in neurosphere , suggesting that pleiotrophin signaling systems are present in the neural stem cells and are involved in the modulation of fate of neural stem cells . . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| The secreted growth factor pleiotrophin ( PTN ) promotes glioblastoma migration and proliferation , initiating its oncogenic activities through two cell surface receptors , the protein tyrosine phosphatase receptor zeta ( PTPRZ 1 ) and the anaplastic lymphoma kinase ( ALK ) , respectively . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Similarly , the synthetic corresponding peptide P 111 136 displayed in vitro inhibition of wild type HARP activities , but in this case , the inhibition was mainly explained by the competition of the peptide with HARP for the binding to the extracellular domain of the high affinity ALK receptor . . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Recent reports of ALK expression in a range of carcinoma derived cell lines together with its apparent role as a receptor for PTN and MK , both of which have been implicated in tumourigenesis , raise the possibility that ALK mediated signalling could play a role in the development and / or progression of a number of common solid tumours . ^^^ |
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| Interacting proteins: Q9UM73 and P21246 |
Pubmed |
SVM Score :0.0 |
| Targeting of the PTN receptors , ALK and RPTP zeta , indicates a contribution of PTN activated signaling pathways in glioblastomas . ^^^ However , the relevance of PTN expression itself is unknown especially since , besides PTN , at least one more growth factor , midkine ( MK ) , signals through ALK and is expressed in glioblastoma . ^^^ |
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