| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.51894679 |
| We have studied the interactions of the nervous tissue specific chondroitin sulfate proteoglycans neurocan and phosphacan with the extracellular matrix protein tenascin R and two heparin binding proteins , amphoterin and the heparin binding growth associated molecule ( HB GAM ) , using a radioligand binding assay . 0.51894679^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.78731671 |
| Here , we show that pleiotrophin ( PTN ) , a natural ligand for protein tyrosine phosphatase receptor type Z ( Ptprz ) ( also called PTPzeta / RPTPbeta ) , inactivates Ptprz through oligomerization and increases the tyrosine phosphorylation of substrates for Ptprz , G protein coupled receptor kinase interactor 1 ( Git 1 ) and membrane associated guanylate kinase , WW and PDZ domain containing 1 ( Magi 1 ) . 0.78731671^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| The chondroitin sulfate proteoglycans neurocan and phosphacan are believed to modulate neurite outgrowth by binding to cell adhesion molecules , tenascin , and the differentiation factors heparin binding growth associated molecule and amphoterin . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Heterogeneity of the chondroitin sulfate portion of phosphacan / 6B4 proteoglycan regulates its binding affinity for pleiotrophin / heparin binding growth associated molecule . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Furthermore , pleiotrophin ( PTN ) , an endogenous ligand of Ptprz , also induced gastritis specifically in Ptprz+ / + mice when administered orally . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Pleiotrophin , a ligand for Ptprz , increased tyrosine phosphorylation of p 190 RhoGAP in B 103 neuroblastoma cells . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| The secreted growth factor pleiotrophin ( PTN ) promotes glioblastoma migration and proliferation , initiating its oncogenic activities through two cell surface receptors , the protein tyrosine phosphatase receptor zeta ( PTPRZ 1 ) and the anaplastic lymphoma kinase ( ALK ) , respectively . ^^^ Using a panel of glioblastoma cell lines , including low passage patient derived cultures , we demonstrate that PTN 15 promotes glioblastoma proliferation in an ALK dependent fashion , whereas immobilized PTN 18 promotes haptotactic migration of glioblastoma cells in a PTPRZ 1 dependent fashion . ^^^ To demonstrate clinical relevance , we show that PTN 15 , PTN 18 , and PTPRZ 1 are significantly overexpressed in glioblastoma relative to normal brain at both mRNA and protein levels using microarray , Western blot , and tissue microarray analyses on human tumors . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Pleiotrophin / heparin binding growth associated molecule ( HB GAM ) is a specific ligand of protein tyrosine phosphatase zeta ( PTPzeta ) / receptor like protein tyrosine phosphatase beta ( RPTPbeta ) expressed in the brain as a chondroitin sulfate proteoglycan . ^^^ Pleiotrophin / heparin binding growth associated molecule ( HB GAM ) is a specific ligand of protein tyrosine phosphatase zeta ( PTPzeta ) / receptor like protein tyrosine phosphatase beta ( RPTPbeta ) expressed in the brain as a chondroitin sulfate proteoglycan . ^^^ Pleiotrophin and PTPzeta isoforms are localized along the radial glial fibers , a scaffold for neuronal migration , suggesting that these molecules are involved in migratory processes of neurons during brain development . ^^^ In this study , we examined the roles of pleiotrophin PTPzeta interaction in the neuronal migration using cell migration assay systems with glass fibers and Boyden chambers . ^^^ Polyclonal antibodies against the extracellular domain of PTPzeta , PTPzeta S , an extracellular secreted form of PTPzeta , and sodium vanadate , a protein tyrosine phosphatase inhibitor , added into the culture medium strongly suppressed specifically the pleiotrophin induced neuronal migration . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of PTN , its putative receptor , namely protein tyrosine phosphatase zeta ( PTPzeta , also known as RPTPbeta ) , and a related protein , receptor type protein tyrosine phosphatase gamma ( RPTPgamma ) , in human colorectal cancers and the adjacent normal mucosae . ^^^ PTN and PTPzeta mRNA levels were generally decreased in colorectal cancers as compared to those in adjacent normal mucosae , while the RPTPzeta level was not significantly different between them . . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Pleiotrophin has been demonstrated to bind to protein tyrosine phosphatase zeta ( PTPzeta ) with high affinity . ^^^ Midkine and pleiotrophin binding to PTPzeta were equally inhibited by soluble pleiotrophin and also by some specific glycosaminoglycans . ^^^ These results suggested that PTPzeta is a common receptor for midkine and pleiotrophin . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Supporting these data , the cells examined expressed PTPzeta , a receptor type protein tyrosine phosphatase that exhibits high affinity to both midkine and pleiotrophin and harbors chondroitin sulfate chains . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Moreover , pleiotrophin , a ligand for PTPzeta , increased tyrosine phosphorylation of GIT1 / Cat 1 in B 103 cells . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| A chondroitin sulfate proteoglycan , protein tyrosine phosphatase zeta ( PTPzeta ) , is a receptor for MK and PTN . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| PTPzeta / RPTPbeta , a receptor type protein tyrosine phosphatase synthesized as a chondroitin sulfate ( CS ) proteoglycan , uses a heparin binding growth factor pleiotrophin ( PTN ) as a ligand , in which the CS portion plays an essential role in ligand binding . ^^^ Using an organotypic slice culture system , we tested the hypothesis that PTN PTPzeta signaling is involved in the morphogenesis of Purkinje cell dendrites . ^^^ An aberrant morphology of Purkinje cell dendrites such as multiple and disoriented primary dendrites was induced in slice cultures by ( 1 ) addition of a polyclonal antibody against the extracellular domain of PTPzeta , ( 2 ) inhibition of protein tyrosine phosphatase activity , ( 3 ) enzymatic removal of the CS chains , ( 4 ) addition of exogenous CS chains , and ( 5 ) addition of exogenous PTN , all of which disturb PTN PTPzeta signaling . ^^^ Altogether , these findings suggest that PTN PTPzeta signaling regulates the morphogenesis of Purkinje cell dendrites and that the mechanisms underlying that regulation involve the GLAST activity in Bergmann glial processes . . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| Pleiotrophin is an 18 kDa heparin binding growth factor , which uses chondroitin sulfate ( CS ) proteoglycan , PTPzeta as a receptor . ^^^ It has been suggested that the D type structure ( GlcA ( 2S ) beta 1 3GalNAc ( 6S ) ) in CS contributes to the high affinity binding between PTPzeta and pleiotrophin . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| The protein tyrosine phosphatase zeta / receptor type protein tyrosine phosphatase beta ( PTPzeta / RPTPbeta ) and its ligand pleiotrophin ( PTN ) are overexpressed in human glioblastomas . ^^^ In addition , PTN can induce glioma cell migration which is at least in part mediated through binding to PTPzeta / RPTPbeta . ^^^ Matrix immobilized PTN stimulated the proliferation of PTPzeta + cells but not of PTPzeta cells . ^^^ Haptotactic migration induced by PTN was reduced for PTPzeta clones compared with control clones . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| No inhibitory effect of pleiotrophin , a natural RPTPbeta ligand , on VacA binding to RPTPbeta B or Delta 747 was observed , supporting the conclusion that the extracellular region of RPTPbeta B responsible for VacA binding is different from that involved in binding pleiotrophin . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| RPTPbeta is known to facilitate tumor cell adhesion and migration through interactions with extracellular matrix components and the growth factor pleiotrophin . ^^^ |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
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