| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.52242933 |
| Purified N syndecan binds in vitro with high affinity to several extracellular regulatory ligands , including basic fibroblast growth factor , the secreted adhesive protein heparin binding growth associated molecule , and a novel collagen like protein secreted by Schwann cells . 0.52242933^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Co expression of heparin binding growth associated molecule ( HB GAM ) and N syndecan ( syndecan 3 ) in developing rat brain . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Gel electrophoretic characteristics , immunochemical analysis , and partial peptide sequencing revealed that the cell surface component isolated as an HB GAM receptor is N syndecan ( syndecan 3 ) . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Because N syndecan ( syndecan 3 ) was found to function as a receptor in HB GAM induced neurite outgrowth , we have now studied whether the heparan sulfate side chains of N syndecan play a role in HB GAM neuron interactions . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| N syndecan ( syndecan 3 ) functions as a receptor / coreceptor in HB GAM induced neurite outgrowth in perinatal rat brain neurons . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| N syndecan ( syndecan 3 ) was previously isolated as a cell surface receptor for heparin binding growth associated molecule ( HB GAM ) and suggested to mediate the neurite growth promoting signal from cell matrix bound HB GAM to the cytoskeleton of neurites . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| HB GAM is highly expressed in embryonic and early post natal fiber pathways of the nervous system , and it enhances axonal growth / guidance by binding to N syndecan ( syndecan 3 ) at the neuron surface . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Further , the mutant mice were not responsive to the syndecan 3 ligand heparin binding growth associated molecule , which inhibits LTP in area CA 1 in wild type animals . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| In transgenics and controls , PTN ( and its receptor syndecan 3 ) was synthesized by osteoblasts and was present in striated muscle . ptn over expression enhanced intramembranous bone formation and had multiple effects on long term bone growth . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Expression of PTN receptors ( syndecan 3 , PTP zeta ) was detected on the cultured mesencephalic neurons , and also up regulated in DA depleted striatum . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| The proteoglycan receptors syndecan 3 and the receptor protein tyrosine phosphatase zeta / beta were found among the transcripts preferentially expressed under control conditions , and their ligand , the cytokine pleiotrophin , was highly represented in the cDNA libraries for both conditions . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| The finding that soluble N syndecan is also inhibitory suggests that the transmembrane proteoglycan N syndecan , previously identified as an HB GAM receptor , is involved in the mRNA localizing effect of HB GAM . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| N syndecan and HB GAM ( heparin binding growth associated molecule ) associate with early axonal tracts in the rat brain . ^^^ The heparan sulphate proteoglycan N syndecan ( Raulo et al . , 1994 ) has been isolated as a receptor / coreceptor for the HB GAM . ^^^ We have investigated , whether HB GAM and N syndecan could have a similar role in neurite outgrowth and axon guidance in early axonal tracts of brain . ^^^ Later , N syndecan and HB GAM were detected in the first afferent serotonergic projections arising from the pontine raphe nuclei . ^^^ At the same time , N syndecan was expressed in the developing raphe neurones growing neurites towards the diencephalon along HB GAM immunoreactive pathways . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , N syndecan , which acts as a receptor for HB GAM , is expressed by osteoblasts / osteoblast precursors , whose ultrastructural phenotypes suggest active cell motility . ^^^ The hypothesis that HB GAM / N syndecan interaction mediates osteoblast recruitment , as inferred from developmental studies , was tested using osteoblast type cells that express N syndecan abundantly . ^^^ Our hypothesis that HB GAM / N syndecan interaction participates in regulation of osteoblast recruitment was tested using two different in vivo models : an adjuvant induced arthritic model and a transgenic model . ^^^ In the adjuvant induced injury model , the expression of HB GAM and of N syndecan is strongly upregulated in the periosteum accompanying the regenerative response of bone . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| We show here that the expression of the neurite outgrowth promoting protein heparin binding growth associated molecule ( HB GAM ) and N syndecan , a transmembrane heparan sulphate proteoglycan previously isolated as a receptor for HB GAM , is spatiotemporally associated with the developing thalamocortical pathway in the rat brain . ^^^ Using in situ hybridization , thalamic neurons were shown to express mRNA for N syndecan , and in vitro , thalamic neurons grew more neurites on HB GAM than on laminin . ^^^ The HB GAM induced neurite outgrowth in thalamic neurons was inhibited by heparitinase , heparin , soluble N syndecan and by an excess of soluble HB GAM in the culture medium . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of N syndecan , a PTN receptor , was up regulated in GalN treated hepatocytes . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| The mRNA transcripts of PTN and its receptors [ receptor protein tyrosine phosphatase ( RPTP ) beta / zeta , N syndecan and anaplastic lymphoma kinase ( ALK ) ] were detected in neurosphere , suggesting that pleiotrophin signaling systems are present in the neural stem cells and are involved in the modulation of fate of neural stem cells . . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| The two thrombospondin type 1 repeat domains of HB GAM display a cooperative function in N syndecan binding and regulation of synaptic plasticity . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| When ligated by heparin binding ( HB ) growth associated molecule ( GAM ; pleiotrophin ) , N syndecan mediates cortactin Src kinase dependent neurite outgrowth . ^^^ |
|
| Interacting proteins: O75056 and P21246 |
Pubmed |
SVM Score :0.0 |
| NA |
|