| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.66065824 |
| This modification of Dok 1 increases its association with RasGAP , suggesting that it is modulating Ras activity . 0.66065824^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Immunoblotting with an Ab reportedly specific for the ras GTPase activating protein ( GAP ) associated p 62 protein revealed that the pp 62 present in CML blasts is not immunologically related to the former protein . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Dok 2 was shown to be 35 % identical to p 62 ( dok 1 ) , a recently identified RasGAP binding protein from CML cells , and analysis of the expressed sequence tag data base revealed the presence of at least four additional proteins containing a Dok homology sequence motif . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| A major substrate of Bcr Abl was recently identified as the RasGAP associated 62 kDa docking protein Dok 1 . ^^^ In contrast , association of Dok 1 with SHIP 1 or RasGAP was mutually exclusive . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| We now report that SH2D1A associates with Dok 1 , a protein that interacts with Ras GAP , Csk , and Nck . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Although it has been proposed to contribute to the control of cell growth and migration through association with the Ras GTPase activating protein and the adapter protein Nck , the role of Dok 1 remains largely unknown . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| This signal involves the SH 2 domain containing inositol phosphatase ( SHIP ) ; the adaptor molecules Dok 2 , Dok 1 and Shc ; and Ras GTPase activating protein RasGAP . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Further studies suggest that 5 Src phosphorylation sites on Dok 1 are critical for its binding to RasGAP and Csk , negative regulators of Src signaling . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| We evaluated intracellular signaling through RasGAP associated protein p62Dok 1 ( downstream of tyrosine kinase [ Dok 1 ] ) and associated proteins . ^^^ SDF 1alpha / CXCL12 stimulated Dok 1 tyrosine phosphorylation and association with RasGAP , adaptor protein p46Nck , and Crk L in Jurkat T cells . ^^^ These results implicate Dok 1 , Nck , Crk L , and Src kinases especially Lck , Pyk 2 , Zap 70 , Vav , and Ras GAP in intracellular signaling by SDF 1alpha / CXCL12 , and they suggest that Dok 1 plays an important role in SDF 1alpha / CXCL12 induced chemotaxis in T cells . . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Upon phosphorylation , Dok 1 binds to SHIP and both Dok 1 and Dok 2 recruit RasGAP , which mediates the inhibition of the Ras / MAPK pathways . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Treatment with dexamethasone also enhanced tyrosine phosphorylation of Dok 1 , augmented recruitment of Ras GTPase activating protein ( RasGAP ) by Dok 1 , and inhibited activation of the mitogen activated protein ( MAP ) kinase pathway in antigen stimulated cells . ^^^ The same effects were obtained by transient overexpression of Dok 1 but not by overexpression of Dok 1 that was mutated in RasGAP binding domain . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Members of this family such as p62dok ( Dok 1 ) and p56dok 2 ( Dok 2 ) associate with the p 120 rasGTPase activating protein ( rasGAP ) upon phosphorylation by p210bcr / abl as well as receptor and nonreceptor tyrosine kinases . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| On the other hand , Dok 1 negatively regulates PDGF induced MAPK activation by acting on Ras GAP and at least one other Dok 1 interacting protein . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| In cells , 5 Abl tyrosine kinase binds and strongly phosphorylates p62dok , which then binds rasGAP . ^^^ A monoclonal antibody , 2C4 , to the rasGAP associated p 62 reacts with p62dok . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| FRIP is related to the rasGAP associated protein p62dok and is bound by the N terminal SH 2 domain of rasGAP . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of p62Dok resulted in its complex formation with the Ras GTPase activating protein ( RasGAP ) and the Nck adaptor protein . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of p62dok by p210bcr abl inhibits RasGAP activity . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| The RasGAP binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells . ^^^ We show here that FcgammaRIIB BCR coaggregation leads to increased tyrosine phosphorylation of the RasGAP binding protein p62dok , with a concomitant increase in its binding to RasGAP . ^^^ Using chimeric FcgammaRIIB containing the RasGAP binding domain of p62dok , we demonstrate that p62dok contains all structural information required to mediate the inhibitory effect of FcgammaRIIB on Erk activation . . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Dok 4 and dok 5 do not associate with rasGAP or Nck , in contrast to p62dok and dok 2 . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase activating protein and Nck and is essential for inhibiting insulin stimulated activation of Ras and Akt . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of nine cellular proteins was induced or enhanced ; we identified p 120 ( RasGAP ) , p 190 ( RhoGAP ) , p62dok ( downstream of tyrosine kinases ) , and cortactin as H . pylori inducible targets . ^^^ |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|