| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| Among these , Aurora B , RhoA , and the GAP MgcRacGAP have been implicated in cytokinesis , but their underlying mechanisms of action have remained unclear . ^^^ We also report that Aurora B phosphorylates MgcRacGAP on serine residues and that this modification induces latent GAP activity toward RhoA in vitro . ^^^ Together , these findings indicate that during cytokinesis , MgcRacGAP , previously known as a GAP for Rac / Cdc42 , is functionally converted to a RhoGAP through phosphorylation by Aurora B . . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| Recently in Developmental Cell , Minoshima et al . ( 2003 ) establish an important connection between three regulatory molecules that coordinate this process , showing that the mitotic kinase aurora B phosphorylates MgcRacGAP to convert it to a GAP for RhoA , a small GTPase that drives cytokinesis . . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| Two complexes localize to the central spindle and regulate completion of cytokinesis : one , centralspindlin , contains a kinesin like protein and a Rho family GAP ; the second contains Aurora B kinase . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the basic region was phosphorylated with Aurora B kinase , and this phosphorylation prevented the inhibition of GAP activity by PRC 1 . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| Prominent components of the central spindle include aurora B kinase and centralspindlin , a complex containing a Kinesin 6 protein ( ZEN 4 / MKLP1 ) and a Rho family GAP ( CYK 4 / MgcRacGAP ) that is essential for central spindle assembly [ 4 ] . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| In diploid cells , the translocation of Aurora B kinase is critical for positioning of the cleavage furrow , in part through its phosphorylation of the Rho family GTPase activating protein MgcRacGAP which in turn alters activity of RhoA . ^^^ |
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| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96GD4 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|