| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.56560577 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK associated with p 190 RhoGAP ( p 190 ) , RasGAP , c Abl as well as with the focal adhesion molecules p130cas and paxillin . c Abl was found to be associated with RAFTK through the region of RAFTK containing amino acids 419 1009 . 0.56560577^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.76547663 |
| PS GAP is a GTPase activating protein for Cdc 42 and RhoA that was originally identified by its interaction with the tyrosine kinase PYK 2 . 0.76547663^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| Interaction of two proline rich sequences of cell adhesion kinase beta with SH 3 domains of p130Cas related proteins and a GTPase activating protein , Graf . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| The Arf GTPase activating protein ( GAP ) ASAP 1 has been identified in a yeast two hybrid screen as a prominent binder of the proline rich tyrosine kinase 2 ( Pyk 2 ) via SH 3 domain mediated interaction . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| These findings indicate that RAFTK serves as a mediator and an integration point between the GAP proteins and HRG mediated signaling in breast cancer cells , and implicate RAFTK involvement in the MAP kinase pathway and in breast cancer cell invasion . . ^^^ RAFTK / Pyk2 tyrosine kinase mediates the association of p 190 RhoGAP with RasGAP and is involved in breast cancer cell invasion . ^^^ Analyses of the members of the HRG stimulated complex revealed that RAFTK is associated with p 190 RhoGAP ( p 190 ) , RasGAP and ErbB 2 , and plays an essential role in mediating the tyrosine phosphorylation of p 190 by Src . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| The Dok 1 mutants having tyrosine to phenylalanine ( YF ) substitution ( s ) at Tyr 336 and / or Tyr 340 lost their inhibitory effect on Ras and Erk downstream of Src like PTK , Lyn or Fyn , whereas the rasGAP binding of each mutant remained intact . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| Identification of a new Pyk 2 target protein with Arf GAP activity . ^^^ We propose that Pap functions as a GAP for Arf and that Pyk 2 may be involved in regulation of vesicular transport through its interaction with Pap . . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| Identification of a novel protein complex containing annexin 6 , Fyn , Pyk 2 , and the p 120 ( GAP ) C 2 domain . p 120 ( GAP ) ( RasGAP ) has been proposed to function as both an inhibitor and effector of Ras . ^^^ Finally , co immunoprecipitation studies in Rat 1 fibroblasts confirm that Fyn , Pyk 2 , annexin 6 and RasGAP can form a protein complex in mammalian cells . . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| Characterization of PSD 95 and SAP 102 as adaptor proteins for Pyk 2 fills a critical gap in the understanding of the spatial organization of the Pyk 2 Src signaling pathway at the postsynaptic site and reveals a physiological function of the intramolecular SH 3 GK domain interaction in SAP102 . . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Pyk 2 regulates Arf 1 activity by phosphorylation and inhibition of the Arf GTPase activating protein ASAP 1 . ^^^ A prominent binder of Pyk 2 identified by this method was the Arf GTPase activating protein ASAP 1 . ^^^ Phosphorylation of tyrosine 308 and 782 affects the phosphoinositide binding profile of ASAP 1 , and fluorimetric Arf GTPase assays with purified proteins revealed an inhibition of ASAP 1 GTPase activating protein activity by Pyk 2 mediated tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| SDF 1alpha / CXCL12 enhanced the association of RasGAP with Pyk 2 . ^^^ These results implicate Dok 1 , Nck , Crk L , and Src kinases especially Lck , Pyk 2 , Zap 70 , Vav , and Ras GAP in intracellular signaling by SDF 1alpha / CXCL12 , and they suggest that Dok 1 plays an important role in SDF 1alpha / CXCL12 induced chemotaxis in T cells . . ^^^ |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|