| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.71741067 |
| Sam 68 is constitutively associated with the SH 3 domains of Grb 2 and it does not change upon insulin stimulation , but Sam 68 is Tyr phosphorylated and promotes the association of GAP with the Grb 2 SOS complex . 0.71741067^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| A second complex , not identified in other models includes tyrosine phosphorylated p66SHC , Grb 2 , RasGAP and p 190 RhoGAP . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| SH 3 domains from both Grb 2 and PLCgamma 1 , but not RasGAP , bound directly to hSos homologues . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| RasGAP and Shc were also found to associate with GRB 2 in LA significantly more in the conditioned animals . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| PDGF action triggers both mechanisms of Grb 2 disassembly , which probably operate in concert with GAP to attenuate p21ras signaling . . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Recent results have demonstrated a high degree of functional conservation between vertebrate and insect tyrosine kinase signalling pathways , involving such proteins as Son of sevenless , Grb 2 and GAP . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domains of PLC gamma Nterm . , Nck , Grb 2 , GAP and Abl have been model built with high affinity phosphopeptides fitted into the putative binding sites . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Purified amino terminal Src homology 2 ( SH 2 ) domains of GAP , PLCgamma 1 and the p85alpha subunit of PI 3 kinase , as well as the carboxy terminal SH 2 domain of the latter protein and the unique SH 2 domain of Grb 2 , were injected into full grown , stage 6 Xenopus laevis oocytes . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , SH 2 domains from PLCgamma , PI 3 kinase , SHC , and Grb 2 did not bind p 62 . ( 4 ) Tryptic phosphopeptide maps of the Nck and the GAP associated p 62 proteins are identical . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a number of substrates such as GAP , GRB 2 , SHC , FES , CRKL , and paxillin is considered a decisive step in transformation . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| The levels of PI 3 kinase , GLUT 4 , p 70 S6 kinase and Ras mRNA were significantly increased by 89 , 40 , 38 , and 47 % , respectively , with running training ; however , the Nck mRNA level was decreased by 24 % . mRNA levels of SHP 2 , Grb 2 , Sos , Shc , GAP , p 62 and p 90 S6 kinase were unaltered by running training . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| A proline rich fragment of the NR2D subunit ( 2D ( 866 1064 ) ) bound to the Abl SH 3 domain but not to the SH 3 domains from Src , Fyn , Grb 2 , GAP , or phospholipase C gamma ( PLCgamma ) . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Functional studies demonstrated that CR 2 activation induced , within a brief span of 2 min , tyrosine phosphorylation of nucleolin and its interaction with Src homology 2 domains of the p 85 subunit of PI 3 kinase and of 3BP2 and Grb 2 , but not with Src homology 2 domains of Fyn and Gap . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| We studied early successional species , alder ( Alnus hirsuta ( Spach ) Rupr . ) and birch ( Betula platyphylla var . japonica ( Miq . ) Hara ) ; gap phase species , walnut ( Juglans ailanthifolia Carrire ) and ash ( Fraxinus mandshurica var . japonica Rupr . ) ; mid successional species , basswood ( Tilia japonica ( Miq . ) Simonk . ) and elm ( Ulmus davidiana var . japonica ( Rehd . ) Nakai ) ; and the late successional species , maple ( Acer mono Bunge ) . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| With these optimum conditions , the clean ash of less than LOI 3 % was recovered with a yield over 75 % when operated at the diffuser slit gap of 4mm , the diffuser outlet velocity of 16 . 1 18 . 6 m / s , and the distance of 15 cm between diffuser slit and splitter . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Ash ( Fraxinus excelsior L . ) and beech ( Fagus sylvatica L . ) seedlings were grown in the field under three levels of natural light : ( 1 ) open , ( 2 ) gap and ( 3 ) shade . ^^^ Measurements of maximum photochemical efficiency ( Fv / Fm ) of dark adapted leaves at intervals through the day showed that ash had a higher Fv / Fm than beech in open and gap plots but not in shade plots . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| We found that the growth of the GaAs sections is limited by the arsine ( AsH ( 3 ) ) as well as the trimethylgallium ( Ga ( CH ( 3 ) ) ( 3 ) ) partial pressures , whereas the growth of GaP is a temperature activated , phosphine ( PH ( 3 ) ) limited process with an activation energy of 115 + / 6 kJ / mol . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| No phosphorylation of Ras GTPase activating protein , p 64 Syp / PTP1D tyrosine phosphatase , or association of the GRB 2 adaptor protein SH 2 domain with these receptors was detected . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| In contrast , Grb 2 , Crk , Abl , p 85 phosphatidylinositol 3 kinase , and GTPase activating protein SH 2 domains showed lower or no binding to Fyn or Lck SH 3 domains . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Mitotic , tyrosine phosphorylated Sam 68 bound selectively to recombinant SH 2 domains with significantly different affinities ( c Src approximately Ras GTPase activating protein > p 85 alpha ( amino terminal ) > Grb 2 > > p 85 alpha ( COOH terminal ) ) . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^ In addition , we demonstrate that phospholipase C gamma 1 , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , and Src family tyrosine kinases , but not Ras GTPase activating protein , Vav , or Nck , physically associate with the Flk2 / Flt3 cytoplasmic domain . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| In addition , phosphatidylinositol 3 kinase from cell lysates was also found stably associated with these domains , but GTPase activating protein , Vav , Sos 1 , or Grb 2 were not . . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Three proteins of the Ras signalling pathway were also shown to associated with CD 45 : the GTPase activating protein for Ras ( rasGAP ) , the signalling protein Grb 2 , and , possibly via complex formation with Grb 2 , the guanine nucleotide exchange factor mammalian son of sevenless ( mSOS ) . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| The interaction appears to be selective , since no binding of the proline rich N terminus of zyxin with other SH 3 domain containing proteins such as GRB 2 , phospholipase C gamma , GTPase activating protein , or p 85 was detected . . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH 2 domains of multiple signalling molecules in vitro , including Grb 2 , Ras GTPase activating protein , phospholipase C gamma , the 85 , 000 M ( r ) subunit of phosphatidylinositol 3 ' kinase , and the Abl tyrosine kinase . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| The highest binding was observed with SH 3 domains of c Src , phospholipase C gamma , p 85 subunit of phosphatidylinositol 3 kinase , full length and NH ( 2 ) terminal Grb 2 , whereas binding was moderate with the SH 3 domains of amphiphysins I / II , Crk , alpha spectrin , and NADPH oxidase factor p 47 ( phox ) and negligible with the SH 3 domains of p 21 ( ras ) GTPase activating protein and COOH terminal Grb 2 . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of epidermal growth factor receptor regulated by Grb 2 mediated recruitment of the Rab 5 GTPase activating protein RN tre . ^^^ Grb 2 functions through association with RN tre , a GTPase activating protein for Rab 5 . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Insulin induced tyrosine phosphorylation of a M ( r ) 70 , 000 protein revealed by association with the Src homology 2 ( SH 2 ) and SH 3 domains of p120GAP and Grb 2 . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Whereas the PDGFr associated with PtdIns 3 ' kinase , ras GAP , GRB 2 , and phospholipase C gamma , only GRB 2 and PtdIns 3 ' kinase associated with IRS 1 . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 , Sos , Ras Gap , p21ras , Raf , MEK and MAPK , genetic studies have suggested that two novel proteins , the protein tyrosine phosphatase ( PTPase ) Csw and the transmembrane protein Rho , are involved in RPTK signalling . . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| We found that huntingtin is associated with Grb 2 , RasGAP , and tyrosine phosphorylated EGF receptor . ^^^ In vitro binding studies indicate that SH 3 domains of Grb 2 or RasGAP are required for their binding to huntingtin . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 and Ras GAP appeared in the immunoprecipitates by anti insulin receptor and anti IRS 1 from insulin treated cells . ^^^ In addition , PI 3 kinase was activated by insulin treatment in this cell line and Grb 2 , Ras GAP , and MAP kinase were coprecipitated with Ras from both insulin treated and NGF treated cells . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| During mitosis , Sam 68 undergoes tyrosine phosphorylation , which negatively regulates its nucleic acid binding properties and mediates the interaction of Sam 68 with critical SH 2 containing signaling proteins such as Grb 2 , PLC gamma 1 and Ras GAP . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| SLM 1 bound the SH 2 and SH 3 domains of p 59 ( fyn ) , Grb 2 , phospholipase Cgamma 1 ( PLCgamma 1 ) , and / or p 120 ( rasGAP ) , suggesting it may function as a multifunctional adapter protein for Src during mitosis . ^^^ Moreover , SLM 2 did not associate with the SH 3 domains of p 59 ( fyn ) , Grb 2 , PLCgamma 1 , or p 120 ( rasGAP ) , suggesting that SLM 2 may not function as an adapter protein for these proteins . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| An EphB 2 mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb 2 binding motif at an alternate RasGAP binding site within the kinase domain had little effect on basal Erk MAPK activation . ^^^ In contrast , elimination of all RasGAP binding sites , accompanied by the addition of a Grb 2 binding site within the kinase domain , led to an increase in phospho Erk levels in NG 108 cells following ephrin B 1 stimulation . ^^^ These data suggest that EphB 2 can be designed to repress , stabilize , or activate the Ras Erk MAPK pathway by the manipulation of RasGAP and Grb 2 SH2 domain binding sites and support the notion that Erk MAPK regulation plays a significant role in axon guidance . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor phosphorylated IRS5 / DOK4 associates with RasGAP , Crk , Src , and Fyn , but not phosphatidylinositol 3 kinase p 85 , Grb 2 , SHP 2 , Nck , or phospholipase Cgamma Src homology 2 domains , and activates MAPK in cells . ^^^ |
|
| Interacting proteins: P20936 and P62993 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ |
|