| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin ARF GAP signaling and the cytoskeleton . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| PAG 2 is a paxillin associated protein with ADP ribosylation factor GTPase activating protein activity . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a number of substrates such as GAP , GRB 2 , SHC , FES , CRKL , and paxillin is considered a decisive step in transformation . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Moreover , p 190 , a member of Rho GTPase activating protein ( GAP ) , and RasGAP were coprecipitated with paxillin in adherent cells and angiotensin 2 stimulation reduced the formation of paxillin p 190 and paxillin RasGAP complexes . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Here , we report the identification of a new paxillin binding protein , PAG 3 ( paxillin associated protein with ADP ribosylation factor [ ARF ] GTPase activating protein [ GAP ] activity , number 3 ) , which is involved in regulation of the subcellular localization of paxillin . ^^^ Moreover , overexpression of PAG 3 , but not its GAP inactive mutant , inhibited paxillin recruitment to focal contacts and hampered cell migratory activities , whereas cell adhesion activities were almost unaffected . ^^^ Therefore , our results demonstrate that paxillin recruitment to focal adhesions is not mediated by simple cytoplasmic diffusion ; rather , PAG 3 appears to be involved in this process , possibly through its GAP activity toward ARF proteins . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| We also showed that Git 2 short could antagonize several known ARF 1 mediated phenotypes : overexpression of Git 2 short , but not its GAP inactive mutant , caused the redistribution of Golgi protein beta COP and reduced the amounts of paxillin containing focal adhesions and actin stress fibers . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Within this complex ASAP 1 , which GAP activity is inoperative , can still alter the recruitment of paxillin to the focal complexes , thus indicating that ASAP 1 interferes with focal complexes independently of its GAP activity . . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Leucine zipper mediated homo and hetero dimerization of GIT family p 95 ARF GTPase activating protein , PIX , paxillin interacting proteins 1 and 2 . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| The paxillin LD 4 domain mediates this reduction in Rac activity by recruiting an ADP ribosylation factor GTPase activating protein ( Arf GAP ) that decreases Arf activity , thereby inhibiting Rac . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| We specifically examined a series of proteins known to be p210BCR / ABL substrates , including rasGAP , Shc , SH PTP 2 , SH PTP 1 , CRK L , CBL , paxillin , and STATs , and found that each were also tyrosine phosphorylated in response to p190BCR / ABL and TEL / ABL . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK associated with p 190 RhoGAP ( p 190 ) , RasGAP , c Abl as well as with the focal adhesion molecules p130cas and paxillin . c Abl was found to be associated with RAFTK through the region of RAFTK containing amino acids 419 1009 . ^^^ |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|