| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| To confirm the role of gap junctions in cell death , we induced targeted cell death via intracellular cytochrome c ( Cc ) and examined the induced cells and their neighbors for apoptotic morphology or caspase 3 cleavage . ^^^ |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| Time lapse studies reveal that cell shedding results in genesis of a gap and that shedding usually occurs prior to detectable cellular activation of caspase 3 or nuclear condensation . ^^^ |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| RESULTS : OGD persistently increased gap junction coupling and strongly activated the apoptosis marker caspase 3 in slice cultures . ^^^ |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| This mechanism relies on the partial cleavage of RasGAP by caspase 3 into an amino terminal fragment called fragment N . ^^^ Partial cleavage of RasGAP is required for cell survival under stress conditions because cells expressing an uncleavable RasGAP mutant can not activate Akt , can not prevent amplification of caspase 3 activity , and eventually undergo apoptosis . ^^^ |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| Impaired Akt activity down modulation , caspase 3 activation , and apoptosis in cells expressing a caspase resistant mutant of RasGAP at position 157 . ^^^ RasGAP bears two caspase 3 cleavage sites that are used sequentially as caspase activity increases in cells . ^^^ When caspase 3 is mildly activated , RasGAP is first cleaved at position 455 . ^^^ |
|
| Interacting proteins: P20936 and P42574 |
Pubmed |
SVM Score :0.0 |
| RasGAP , a regulator of Ras and Rho GTPases , is an atypical caspase substrate , since it inhibits , rather than favors , apoptosis when it is partially cleaved by caspase 3 at position 455 . ^^^ |
|