| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Both IL 3 and 5 Abl stimulated the tyrosine phosphorylation of SHC and GTPase activating protein . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| A second complex , not identified in other models includes tyrosine phosphorylated p66SHC , Grb 2 , RasGAP and p 190 RhoGAP . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| RasGAP and Shc were also found to associate with GRB 2 in LA significantly more in the conditioned animals . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| In contrast to SHC , phospholipase C gamma 1 , and the p 85 alpha phosphatidylinositol 3 ' kinase subunit , the endogenous GAP product ( p120GAP ) was highly tyrosine phosphorylated only in cells transformed by wild type 5 src . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunodetection was used to compare the expression and tyrosine phosphorylation state of PLC gamma 1 , EGFR , phosphatidylinositol 3 kinase ( PI 3 kinase ) , ras guanosine triphosphatase activating protein ( GAP ) , and src homologous collagen like protein ( SHC ) in the postnatal rat intestine . ^^^ EGFR and SHC expression were increased in weanling compared with suckling and adult animals ; however , differences in expression of PI 3 kinase and GAP did not occur during weaning . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| GAP , Vav , Shc , and to a lesser extent PLC gamma become tyrosine phosphorylated but no in vivo association with the receptor was detectable . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Ligand caused p 120 rasGTPase activating protein ( GAP ) , SHC and the p 85 subunit of phosphatidylinositol 3 ' kinase ( PI3K ) to be associated with both p185c erbB 2 and p180erbB 4 . ^^^ In addition , tyrosine phosphorylation of p 85 PI3K and SHC , but not of GAP or of its associated p 62 and p 190 proteins , was also detected . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , SH 2 domains from PLCgamma , PI 3 kinase , SHC , and Grb 2 did not bind p 62 . ( 4 ) Tryptic phosphopeptide maps of the Nck and the GAP associated p 62 proteins are identical . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| The ras and ODC transformed cells did not show constitutively elevated tyrosine phosphorylation of the phospholipase Cgamma 1 ( PLCgamma 1 ) , RasGTPase activating protein ( GAP ) , phosphotyrosine phosphatase Syp , Shc proteins , and phosphatidylinositol 3 kinase ( PI 3 K ) or activation of the MAP kinase ( Erk 1 and Erk 2 ) , p 70 S6 kinase or the Janus protein tyrosine kinase ( JAK ) and signal transducer and activator of transcription ( STAT ) protein 1 pathways . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a number of substrates such as GAP , GRB 2 , SHC , FES , CRKL , and paxillin is considered a decisive step in transformation . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| The levels of PI 3 kinase , GLUT 4 , p 70 S6 kinase and Ras mRNA were significantly increased by 89 , 40 , 38 , and 47 % , respectively , with running training ; however , the Nck mRNA level was decreased by 24 % . mRNA levels of SHP 2 , Grb 2 , Sos , Shc , GAP , p 62 and p 90 S6 kinase were unaltered by running training . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases , from the adaptor protein SHC and from GTPase activating protein in Ramos B cells . ^^^ Also the SHC derived SH 2 domain formed complexes with the tyrosine phosphorylated Ig alpha / beta heterodimer , while the C and N terminal SH 2 domains of GTPase activating protein displayed completely different binding preferences . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that SH 2 domains expressed as recombinant glutathione S transferase fusion proteins ( GST SH 2 ) from GTPase activating protein , Shc , zeta chain associated protein tyrosine kinase Zap 70 , and Src like tyrosine kinases precipitated distinct sets of phospho proteins from activated B cells . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| The tyrosine phosphorylated SHC was not bound by the GTPase activating protein of Ras although a distinct 62 kDa tyrosine phosphorylated protein was found to be associated in the same experiments . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^ In addition , we demonstrate that phospholipase C gamma 1 , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , and Src family tyrosine kinases , but not Ras GTPase activating protein , Vav , or Nck , physically associate with the Flk2 / Flt3 cytoplasmic domain . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| In contrast to EGF induced tyrosine phosphorylation of the GTPase activating protein for ras ( rasGAP ) and phospholipase C gamma 1 ( PLC gamma 1 ) , SHC tyrosine phosphorylation occurs at a very low receptor density in parental NIH3T3 mouse fibroblasts expressing less than 1 10 10 ( 4 ) EGF receptors per cell . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| The in vivo interaction with the EGFr / p185c neu heterodimer of several signal transduction proteins , including phospholipase C gamma 1 ( PLC gamma 1 ) , the p 85 subunit of phosphotidylinositol 3 kinase , the ras GTPase activating protein , SHC , NCK , p72RAF , and the tyrosine phosphatase SHPTP 2 , was measured by coimmunoprecipitation . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors , including SHC , signal transducer and activator of transcription ( Stat ) 1alpha , beta , Stat 3 , Stat 5 , phospholipase C gamma , insulin receptor substrate 1 , GTPase activating protein , beta catenin , gamma catenin , p120cas , SHP 1 , and SHP 2 . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| PDGF induced tyrosine phosphorylation of phospholipase Cgamma , the p 85 regulatory subunit of phosphatidyl inositol 3 kinase , Ras GTPase activating protein , and an adaptor molecule Shc were also not altered . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Others are molecules such as phospholipase C gamma , phosphoinositol 3 kinase , Shc , GTPase activating protein , and the SH 2 containing tyrosine phosphatases SHP 1 and SHP 2 . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| PLC gamma , ras GAP and Shc have been proposed to be in vivo substrates for the neu encoded p185neu receptor tyrosine kinases . ^^^ We compared the tyrosine phosphorylation levels of PLC gamma , ras GAP and Shc in two NIH3T3 derived cell lines , transformed B 104 1 1 and non transformed DHFR / G8 cells in which point mutation activated and normal rat neu genes were transfected and expressed , respectively . ^^^ We found that tyrosine phosphorylation of Shc and formation of Shc / Grb2 complex were more significant in B 104 1 1 cells than in DHFR / G8 cells , while no obvious difference could be detected for the tyrosine phosphorylation levels of ras GAP and PLC gamma between these two cell lines . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Concomitant tyrosine phosphorylation of eps 8 and shc , but not of rasGAP , phospholipase C gamma , and eps 15 , was frequently detected in tumor cells . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that the SH 2 domain of BCR ABL is not required for the induction of growth factor independence and is not required for the association of BCR ABL with rasGAP or SHC . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| We specifically examined a series of proteins known to be p210BCR / ABL substrates , including rasGAP , Shc , SH PTP 2 , SH PTP 1 , CRK L , CBL , paxillin , and STATs , and found that each were also tyrosine phosphorylated in response to p190BCR / ABL and TEL / ABL . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| We have investigated the roles of the phosphotyrosine phosphatase Syp ( also called SH PTP 2 ) , phospholipase C ( PLC ) gamma 1 , rasGTPase Activating Protein ( rasGAP ) and the adapter molecules Nck and Shc in the mitogenic response induced by PDGF in fibroblasts . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Analysis of specific effector molecules revealed that tyrosine phosphorylation of Shc , but not rasGAP or Vav , correlated with the unique ability of BCR ligation to trigger p21ras activation in CD45+ cells . ^^^ |
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| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| We conclude that the initial burst of Src activity is required for efficient tyrosine phosphorylation of receptor associated proteins such as PLCgamma , RasGAP , Shc , and SHP 2 and for maximal activation of Erk . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| This signal involves the SH 2 domain containing inositol phosphatase ( SHIP ) ; the adaptor molecules Dok 2 , Dok 1 and Shc ; and Ras GTPase activating protein RasGAP . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| It is also shown that multiple signaling molecules , including PI3K , SHC , ras GAP and CRK L , are tyrosine phosphorylated in Ba / F3 cells that express ETV6 / ARG . ^^^ |
|
| Interacting proteins: P20936 and P29353 |
Pubmed |
SVM Score :0.0 |
| TEL / ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins , including rasGAP , CBL , STAT 5 , PI3K , SHP 2 , Dok , and SHC . ^^^ |
|