| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :1.0496934 |
| RasGAP also bound through its SH 2 domains to tyrosine phosphorylated EphB 2 in vitro , and complexed with activated EphB 2 in vivo . 1.0496934^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Under the working hypothesis that the hyperpolarizing component of the GABA evoked response is mediated by the activation of GABAB receptors , we have examined , using the sucrose gap technique , some characteristics of the response of DRT to baclofen . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| We conclude that the initial burst of Src activity is required for efficient tyrosine phosphorylation of receptor associated proteins such as PLCgamma , RasGAP , Shc , and SHP 2 and for maximal activation of Erk . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| We found that binding of RasGAP to the wild type betaPDGFR was decreased ; the activation of Ras and Erk was enhanced , and [ 3H ] thymidine uptake was better in cells cultured on fibronectin than in cells cultured on polylysine . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Taken together , it is concluded that okadaic acid induces the expression of p 100 RasGAP protein in JEG 3 cells preceded by activation of ERK and AP 1 cascade , and that this okadaic acid induced p 100 RasGAP expression is independent of protein kinase C mediated pathway but requires c Jun / AP 1 function . . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Using chimeric FcgammaRIIB containing the RasGAP binding domain of p62dok , we demonstrate that p62dok contains all structural information required to mediate the inhibitory effect of FcgammaRIIB on Erk activation . . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| After IL 2 stimulation , phosphorylated SOCS 3 strongly inhibits STAT 5 activation but , by binding to RasGAP , maintains activation of extracellular signal regulated kinase ( ERK ) . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| FGF induced sustained activation of extracellular signal regulated kinase ( ERK ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . ^^^ These findings support a model in which regional differences in FGF signaling through the ERK pathway lead to the asymmetry in gap junctional coupling required for proper lens function . ^^^ Our results also identify upregulation of intercellular communication as a new function for sustained ERK activation and change the current paradigm that ERKs only negatively regulate gap junction channel activity . . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Inhibition of connexin 43 gap junctional intercellular communication by TPA requires ERK activation . ^^^ TPA treatment ( 10 ng / ml for 30 min ) of WB F 344 rat liver epithelial cells strongly activated p 42 and p 44 ERK 1 and 2 , blocked gap junction mediated fluorescent dye coupling , and induced connexin 43 hyperphosphorylation and gap junction internalization . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Thus , stimulation of the ERK and p 38 signal pathways via ETA and AT 1 receptors may partcipate in the regulation of cardiac gap junctions under ( patho ) physiological conditions . . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Gap junction uncoupling in bradykinin stimulated porcine coronary endothelial cells was prevented by inhibiting the activation of extracellular signal regulated kinase ( ERK ) 1 / 2 . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Bisphosphonate induced , hemichannel mediated , anti apoptosis through the Src / ERK pathway : a gap junction independent action of connexin 43 . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| The extracellular regulated kinases ( ERK ) 1 / 2 mediate cannabinoid induced inhibition of gap junctional communication in endothelial cells . 1 . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| As a consequence , red wine abrogates the ligand induced recruitment of betaPDGFR associated signaling molecules ( RasGAP , SHP 2 , PI3K , PLCgamma ) , PDGF dependent downstream events such as Erk activation and induction of immediate early genes , and VSMC proliferation and migration . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| An EphB 2 mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb 2 binding motif at an alternate RasGAP binding site within the kinase domain had little effect on basal Erk MAPK activation . ^^^ In contrast , elimination of all RasGAP binding sites , accompanied by the addition of a Grb 2 binding site within the kinase domain , led to an increase in phospho Erk levels in NG 108 cells following ephrin B 1 stimulation . ^^^ These data suggest that EphB 2 can be designed to repress , stabilize , or activate the Ras Erk MAPK pathway by the manipulation of RasGAP and Grb 2 SH2 domain binding sites and support the notion that Erk MAPK regulation plays a significant role in axon guidance . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Both tyrosine phosphatase activity and GAP activity were responsible for SptP inhibition of Raf ( Y340D ) induced ERK activation , but only GAP activity was responsible for inhibition of the membrane localized forms of Raf 1 . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Inhibition of ERK pathway by PD 98059 , a MEK 1 specific inhibitor , prevented Lindane induced Cx 43 phosphorylation , restored Cx 43 membranous localization and gap junction coupling . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| ERK activation resulted in phosphorylation at Ser 279 and Ser 282 of the gap junctional protein , connexin 43 , known to result in the loss of gap junctional intercellular communication . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| In dyssynchronous failing hearts , the lateral LV endocardium displayed a 2 fold increase in phosphorylated erk mitogen activated protein kinase expression ( with no change in phospho p 38 or phospho jnk ) , a 30 % decline in sarcoplasmic reticulum Ca2+ ATPase , an 80 % reduction in phospholamban , and a 60 % reduction in the gap junction protein connexin 43 , relative to neighboring myocardial segments . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| The increased ASM cellular gap and cell shape change by proteolytic activity of HNE may be contributory to ERK activation and therefore cell proliferation . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Dok 1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras Erk signalling , but dispensable for rasGAP binding . ^^^ It recruits rasGAP and other SH 2 containing proteins and negatively regulates Ras Erk signalling downstream of PTKs . ^^^ The Dok 1 mutants having tyrosine to phenylalanine ( YF ) substitution ( s ) at Tyr 336 and / or Tyr 340 lost their inhibitory effect on Ras and Erk downstream of Src like PTK , Lyn or Fyn , whereas the rasGAP binding of each mutant remained intact . ^^^ However , the Dok 1 mutant having YF substitutions at the rasGAP binding sites ( Tyr 295 and Tyr 361 ) also showed incapability of Ras and Erk inhibition . ^^^ These results demonstrate that Tyr 336 and Tyr 340 of Dok 1 are dispensable for rasGAP binding but essential for inhibition of Ras Erk signalling and cellular transformation downstream of PTKs . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that transcription from the gap junction dependent osteocalcin CxRE is regulated by extracellular signal regulated protein kinase ( ERK ) and phosphatidylinositol 3 kinase ( PI3K ) cascades . ^^^ Importantly , disruption of gap junctional communication by overexpression of connexin 45 or treatment with pharmacological inhibitors of gap junctions results in reduced Raf , ERK , and Akt activation . ^^^ The consequence of attenuated gap junction dependent signal cascade activation is a decrease in Sp 1 phosphorylation by ERK , resulting in decreased Sp 1 recruitment to the CxRE and inhibited gene transcription . ^^^ These data establish that ERK / PI3K signaling is required for the optimal elaboration of transcription from the osteocalcin CxRE , and that disruption of gap junctional communication attenuates the ability of cells to respond to an extracellular cue , presumably by limiting the propagation of second messengers among adjacent cells by connexin 43 gap junctions . . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Moreover , the synaptic Ras GTPase activating protein ( GAP ) SynGAP is selectively associated with NR2B NMDARs in brain and is required for inhibition of NMDAR dependent ERK activation . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Our findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP 1 via the coupling of its proline rich region , which targets EEN and its functional GAP domain . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Studies in GH4C1 cells , with an expression vector for Rap 1 GTPase activating protein ( Rap 1 GAP1 ) , demonstrated reduced VIP induced MAPK activation , indicating that VIP dependent activation of the extracellular signal regulated kinase ( ERK ) pathway requires PKA Rap 1 signaling . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Furthermore , inactivation of Rac by expression of the Rac GTPase activating protein beta 2 chimerin inhibited HRG induced ERK activation , mitogenicity , and migration in breast cancer cells . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that the abrogation of Rap 1 activation by SPA 1 , a Rap 1 specific GAP , inhibits activation of B Raf , MEK , Erk , and Akt in a murine hematopoietic cell line , Ton . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK dependent mechanism . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N Ras does not compromise Ras dependent ERK ( extracellular signal regulated kinase ) activation by PE . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Although pY 594 in the EphB1R has previously been shown to bind the SH 2 domain of Nck , we found that stimulation of EphB 1 and EphB 2 led predominantly to a complex between NIK / Nck , p 62 ( dok ) , RasGAP , and an unidentified 145 kDa tyrosine phosphorylated protein . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| Inactivation of Ras , induced by ephrin B 1 stimulation of NG 108 neuronal cells , requires EphB 2 tyrosine kinase activity and is blocked by a truncated form of p 120 Ras GTPase activating protein ( p 120 RasGAP ) , suggesting that EphB 2 signals through the SH 2 domain protein p 120 RasGAP to inhibit the Ras MAPK pathway . ^^^ |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|