| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Small gap junctions were observed between gastric surface mucous cells in all healthy volunteers . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Potential molecules implicated in downstream signaling pathways of p185BCR ABL in Ph+ ALL involve GTPase activating protein , phospholipase C gamma 1 , and phosphatidylinositol 3 ' kinase . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the proportion of verb use that consisted of General All Purpose ( GAP ) verbs for children with SLI was similar to that of the MLU matched children . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Although in the last 20 years , the WHO ' Health for All ' principles have been widely used in national , regional and local health policy documents , there is still a gap in the literature regarding how to appraise or compare them , which weakens the social accountability process . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Intense clinical and laboratory research is attempting to close the gap in outcome between children and adults with ALL . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The second domain is similar to a portion of BCR , a GTPase activating protein encoded by the breakpoint cluster region gene . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Identification of a protein that binds to the SH 3 region of Abl and is similar to Bcr and GAP rho . ^^^ The sequence of the 3BP 1 protein is similar to that of a COOH terminal segment of Bcr and to guanosine triphosphatase activating protein ( GAP ) rho , which suggests that it might have GAP activity for Ras related proteins . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| BCR and n chimaerin are prototypes of a new GAP family for these p21s . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| We show here that the carboxy terminal domains of the bcr encoded protein ( Bcr ) and of a Bcr related protein , n chimaerin , are both GAP proteins for the Ras related GTP binding protein , p21rac . ^^^ Bcr encodes a GTPase activating protein for p21rac . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The same two effector sites are essential for rac induced actin polymerization in fibroblasts . p65PAK , a ubiquitous serine / threonine kinase , interacts with rac at both the N and C terminal effector sites , but the GTPase activating protein , bcr interacts with rac at a different region . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The human bcr gene encodes a protein with serine / threonine kinase activity , CDC24 / dbl homology , a GAP domain , and an SH 2 binding region . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| As suggested by the deduced amino acid sequence , this regulator protein shows a similarity to the GTPase activating protein ( GAP ) homology region of Bcr and possesses GAP activity for RhoA , but not for Rac 1 ; no guanine nucleotide exchange activity for RhoA and Rac 1 was detected . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that the SH 2 domain of BCR ABL is not required for the induction of growth factor independence and is not required for the association of BCR ABL with rasGAP or SHC . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The GTPase activating protein domain from the Bem 2 protein ( Bem2p ) or human Bcr can functionally substitute for Bem2p . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The breakpoint cluster region gene product ( Bcr ) is a GTPase activating protein ( GAP ) for members of the Rho family , Cdc42Hs , and Rac 1 , as is the brain protein n chimaerin . ^^^ At least 15 proteins have sequence identity to the GAP domain ( 150 amino acid residues ) of Bcr . ^^^ The widespread occurrence of proteins that possess sequence identity to the Bcr related GAP domain makes it especially important to understand its structure / function relationships . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The product of the breakpoint cluster region gene bcr , rho GTPase accelerating protein ( rhoGAP ) and rasGAP associated p 190 share structurally related rho GAP domains , and possess GAP activity for rho family members in vitro . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Using a polymerase chain reaction strategy exploiting conserved residues in the GAP domains of n chimaerin and the product of the breakpoint cluster region gene ( BCR ) , we isolated a human brain 5 . 3 kilobase cDNA containing a 486 base pair region with complete identity to a previously reported active BCR related ( ABR ) gene sequence on human chromosome 17 . ^^^ The brain cDNA encoded a 98 kDa protein ( ABR ) resembling BCR ( 68 % identity ) , containing both the oncogene dbl related domain at the N terminus and the GAP domain at the C terminus ; however , it lacks the N terminal BCR protein kinase domain . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Although both ABR and BCR have GAP activity , ABR lacks homology to the serine / threonine kinase domain of BCR . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| If an ABL BCR gene product is produced in CML cells , it may be relevant as a mechanism for deregulating the GTPase activating protein ( GAP ) function of BCR . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Because BCR carries a GAP ( GTPase activating protein ) activity toward cytoskeleton related small GTP binding proteins , we utilized a neuronal PC 12 cell system to test morphogenic potentials of BCR ABL or BCR . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Analysis of specific effector molecules revealed that tyrosine phosphorylation of Shc , but not rasGAP or Vav , correlated with the unique ability of BCR ligation to trigger p21ras activation in CD45+ cells . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The differential effects of BCR and BCR FcgammaRIIB 1 mediated signaling on the phosphorylation of GAP A . p62 and its association with Csk suggest that docking of Csk to GAP A . p62 may function in the negative regulation of antigen receptor mediated signals in B cells . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The catalytic efficiencies ( Kcat / Km ) of the GAP domains of Bcr , 3BP 1 , and p 190 on Cdc 42 are found to be 60 , 160 , and over 500 fold less than that of Cdc42GAP , respectively , and the differences are due , to a large part , to differences in Km . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| In contrast with Cdc 42 ( for which the GAP domain of p50RhoGAP is 50 fold more efficient than those of p 190 , Bcr , and 3BP 1 ) and with RhoA ( toward which only p50RhoGAP and p 190 displayed high efficiencies ) , the catalytic efficiencies ( Kcat / Km ) of the GAP domains of p50RhoGAP , p 190 , Bcr , and 3BP 1 on Rac 1 are found to be comparable in a range between 0 . 9 and 2 . 6 min 1 microM 1 . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Both c cbl and ras GAP have been proposed to suppress receptor mediated signaling , and may contribute to CD 5 mediated suppression of TCR or BCR signaling . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The FNR of 1F FISH probes depends on the distance between the BCR and ABL probes hybridized to the BCR ABL fusion gene ( < or =368 kb ) ; the `` gap ' ' between the signals causing the cell to be interpreted as normal . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Characterization of a promiscuous GTPase activating protein that has a Bcr related domain from Caenorhabditis elegans . ^^^ A complementary DNA was isolated from Caenorhabditis elegans that encoded a polypeptide of 1438 amino acid residues , CeGAP , which contains a domain with sequence similarity to the COOH terminal segment ( GTPase activating protein region ) of Bcr and other known GTPase activating proteins of the Rho subfamily . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| It contained several splice junctions conserved with the sequence related protein kinase C and bcr genes . alpha 2 Chimerin is only the second SH 2 containing GAP and the first example of an SH 2 domain generated by alternate splicing . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The cellular Bcr protein consists of an N terminal serine / threonine kinase domain , a central guanine nucleotide exchange factor homology region and a C terminal GTPase activating protein domain . ^^^ Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH 2 domains of multiple signalling molecules in vitro , including Grb 2 , Ras GTPase activating protein , phospholipase C gamma , the 85 , 000 M ( r ) subunit of phosphatidylinositol 3 ' kinase , and the Abl tyrosine kinase . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| We show here that FcgammaRIIB BCR coaggregation leads to increased tyrosine phosphorylation of the RasGAP binding protein p62dok , with a concomitant increase in its binding to RasGAP . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| To fill this gap , the European Commission ' s Standards , Measurements and Testing Programme ( formerly BCR ) has started a European collaborative project of which the aim is to test the feasibility of preparation of wastewater reference materials and the analytical state of the art to enable the certification of trace elements in such matrices . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| In contrast to Rac 1 and RhoA , nonprenylated Cdc 42 is able to interact with membrane localized GAPs . ( 2 ) Full length p50RhoGAP and p190RhoGAP react less intensely with nonprenylated Rac 1 than with the prenylated protein , whereas no difference was observed in the reaction of isolated GAP domains of either p50RhoGAP or Bcr with the different types of Rac 1 . ( 3 ) Fluoride exerts a significant inhibitory effect only on the interaction of prenylated Rac 1 with the isolated GAP domains of p50RhoGAP or Bcr . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The direct BCR was less than one when the price gap between ordinary syringe and AD exceeded RMB 0 . 24 Yuan . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The BCR gene encodes a Rho GTPase activating protein , which is known to play important roles in neurite growth and axonal guidance . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , a large gap still remains between our knowledge of the genes that are altered in CML ( or other malignancies ) and the biological changes underlying the deregulation of growth that is characteristic of malignancy in general . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Granulocyte alkaline phosphatase ( GAP ) was extracted from the leukocyte suspensions of 15 subjects with chronic myeloid leukemia ( CML ) , determining the Zn content by atomic absorption spectrophotometry . ^^^ This suggests that the GAP molecule isolated from CML subjects is not altered as it is able to receive at most 2 Zn moles responsible for the enzymatic function . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Because p 62 , ras GAP and ras are involved in growth factor and oncogene activation of cells , this pathway may also play an important role in CML . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Immunoblotting with an Ab reportedly specific for the ras GTPase activating protein ( GAP ) associated p 62 protein revealed that the pp 62 present in CML blasts is not immunologically related to the former protein . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| The p210bcr / abl tyrosine kinase appears to be responsible for initiating and maintaining the leukemic phenotype in chronic myelogenous leukemia ( CML ) patients . p21ras p120GAP interactions play a central role in transducing mitogenic signals . ^^^ Therefore , we investigated whether p21ras and p120GAP are regulated by p210bcr / abl , and whether this activation is functionally significant for CML cell proliferation . ^^^ We report that transient expression of p210bcr / abl in fibroblast like cells induces simultaneous activation of p21ras and inhibition of GTPase promoting activity of p120GAP , and confirm these data showing that downregulation of p210bcr / abl expression in CML cells with bcr / abl antisense oligodeoxynucleotides induces both inhibition of p21ras activation and stimulation of GTPase promoting activity of p120GAP . ^^^ Thus , the p210bcr / abl dependent regulation of p120GAP activity is responsible , in part , for the maintenance of p21ras in the active GTP bound form , a crucial requirement for CML cell proliferation . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| To determine whether GAP expression is required for the growth of human normal and leukemic hematopoietic cells , we used GAP antisense oligodeoxynucleotides to inhibit it and analyzed the effects of this inhibition on the colony forming ability of nonadherent , T lymphocyte depleted mononuclear cells and of highly purified progenitors ( CD34+ MNC ) obtained from the bone marrow and peripheral blood of healthy volunteers or chronic myeloid leukemia ( CML , bcr abl positive ) patients . ^^^ GAP antisense treatment inhibited colony formation from normal myelo , erythro , and megakaryopoietic progenitor cells as well as from CML progenitor cells . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| In the present studies , we demonstrate that this P tyr p 62 from primary primitive lin chronic phase CML blasts co immunoprecipitates with ras GAP . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine phosphorylated protein that migrates at 62 kDa by SDS PAGE and associates with the p 120 ras GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| Dok 2 was shown to be 35 % identical to p 62 ( dok 1 ) , a recently identified RasGAP binding protein from CML cells , and analysis of the expressed sequence tag data base revealed the presence of at least four additional proteins containing a Dok homology sequence motif . ^^^ These findings strongly suggest that a family of Dok related proteins exists that bind to RasGAP and may mediate the effects of p 210 ( bcr abl ) in CML . . ^^^ |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|