| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :1.0942829 |
| In contrast , however , there is no evidence that GAP is either phosphorylated on tyrosine residues or forms a complex with the activated EGFR in EGF treated MDA 468 cells . 1.0942829^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| We show that RN tre is a Rab 5 GTPase activating protein , whose activity is regulated by the EGFR . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Binding of full length Crk or the isolated SH 2 domains of GAP or Abl resulted in a significant protection of phosphorylated EGFR against dephosphorylation by cellular phosphatase activity , but did not appear to stimulate the intrinsic tyrosine kinase activity of the EGFR . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Because epidermal growth factor receptor phosphorylates the equivalent tyrosine residue in human GAP ( Tyr 460 ) , these findings are consistent with the hypothesis that specific phosphorylation of GAP at this site may have a physiologically important role in regulating mitogenic Ras signaling pathways . . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| The purified recombinant SH 2 domains from GAP and p 85 bind to the tyrosine phosphorylated epidermal growth factor receptor with nanomolar affinities . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| However , under conditions in which activation of the erbB 2 kinase induced DNA synthesis at least fivefold more efficiently than the EGFR , the levels of erbB 2 or EGFR induced tyrosine phosphorylation of PLC gamma and GAP were comparable . ^^^ Thus , our results indicate that differences in tyrosine phosphorylation of PLC gamma and GAP do not account for the differences in mitogenic activity of the erbB 2 kinase compared with either the EGFR or platelet derived growth factor receptor in NIH 3T3 fibroblasts . . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor phosphorylates GTPase activating protein ( GAP ) at Tyr 460 , adjacent to the GAP SH 2 domains . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Previous studies indicated that Tyr 457 of bovine GAP ( Tyr 460 of human GAP ) is the major site of phosphorylation by viral Src ( 5 Src ) kinase and epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunodetection was used to compare the expression and tyrosine phosphorylation state of PLC gamma 1 , EGFR , phosphatidylinositol 3 kinase ( PI 3 kinase ) , ras guanosine triphosphatase activating protein ( GAP ) , and src homologous collagen like protein ( SHC ) in the postnatal rat intestine . ^^^ EGFR and SHC expression were increased in weanling compared with suckling and adult animals ; however , differences in expression of PI 3 kinase and GAP did not occur during weaning . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , the EGF induced phosphorylation of GAP , p 85 , and PLC gamma 1 did not correlate with the dominant negative action of p185K757M on EGFr function . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Ligand caused p 120 rasGTPase activating protein ( GAP ) , SHC and the p 85 subunit of phosphatidylinositol 3 ' kinase ( PI3K ) to be associated with both p185c erbB 2 and p180erbB 4 . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Characterization of MAP kinase mediated phosphorylation of connexin 43 has defined potential targets for phosphorylation in vivo following activation of the epidermal growth factor receptor and has provided the basis for studies of the effects of phosphorylation , at specific molecular sites , on the regulation of gap junctional communication . . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| This mini review focuses on the regulation of gap junctions through phosphorylation of connexin 43 induced by the 5 Src or epidermal growth factor receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Regeneration of rabbit cornea following excimer laser photorefractive keratectomy : a study on gap junctions , epithelial junctions and epidermal growth factor receptor expression in correlation with cell proliferation . ^^^ In the healing process particular attention was focused on the epithelium where gap junction expression and the rearrangement of desmosomes and hemidesmosomes were correlated with cell proliferation and epidermal growth factor receptor expression . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Methyl 1 , 4 naphthoquinone , vitamin K ( 3 ) , decreases gap junctional intercellular communication via activation of the epidermal growth factor receptor / extracellular signal regulated kinase cascade . 2 Methyl 1 , 4 naphthoquinone , vitamin K ( 3 ) ( menadione ) , which is frequently used as a model quinone in cell culture and in vivo studies , was tested for its effects on gap junctional intercellular communication ( GJC ) . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| A modeling of the forward and backward electron transfer kinetics in P 700 F ( A ) / F ( B ) complexes , P 700 F ( 10 ) cores , and P 700 A ( 1 ) cores shows that the replacement of phylloquinone by plastoquinone 9 induces a decrease in the free energy gap between A ( 1 ) and F ( A ) / F ( B ) from approximately 205 mV in wild type PS 1 to approximately 70 mV in menA PS 1 . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| It does not have significant sequence homology with ABC transporters and differs from the ABC transporters in several other important aspects , including ( 1 ) lack of any close homologs in humans , ( 2 ) lack of a classical Walker domain , ( 3 ) integral membrane association without clearly defined transmembrane domains and ( 4 ) its role as a direct link to Ras / Ral / Rho and EGF R signaling through its multifunctional nature , including GAP activity , regulation of exocytosis as well as clathrin coated pit mediated receptor endocytosis . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| The phenotypes of primary cultured cells were evaluated by morphology and immunohistochemical staining with antibodies for proposed keratinocyte stem cell markers ( p 63 , EGFR , K 19 and integrin beta 1 ) and differentiation markers ( K 3 , involucrin and gap junction protein connexin 43 ) . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| A BAR domain in the N terminus of the Arf GAP ASAP 1 affects membrane structure and trafficking of epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Moreover , wild type PLD PX , but not mutated PLD PXs defective for GAP function in vitro , increased epidermal growth factor receptor ( EGFR ) endocytosis at physiological EGF concentrations . ^^^ In addition , the silencing of PLDs was shown to retard EGFR endocytosis and the addition of wild type PLDs or lipase inactive PLDs , but not PLD 1 mutants with defective GAP activity for dynamin in vitro , resulted in the recovery of EGFR endocytosis . ^^^ These findings suggest that PLD , functioning as an intermolecular GAP for dynamin , accelerates EGFR endocytosis . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Presence of SH 2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor . src homology region 2 and 3 ( SH 2 and SH 3 ) domains are conserved noncatalytic regions originally described in cytoplasmic tyrosine kinases and subsequently identified in phospholipase C gamma 1 ( PLC gamma 1 ) , GTPase activating protein of ras , and other signaling proteins . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Binding of the H ras p 21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p 21 GTPase activity in vitro . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Efficient coupling with phosphatidylinositol 3 kinase , but not phospholipase C gamma or GTPase activating protein , distinguishes ErbB 3 signaling from that of other ErbB / EGFR family members . ^^^ By contrast , both phospholipase C gamma and GTPase activating protein failed to associate with or be phosphorylated by the ErbB 3 cytoplasmic domain under conditions in which they coupled with the EGFR . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of ras GTPase activating protein does not require association with the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Incubation of supB+ cells with ( 13S ) HPODE and EGF increased EGFR autophosphorylation and tyrosine phosphorylation on several signaling proteins with Src homology 2 domains including GTPase activating protein . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| On the other hand , RN tre , a Rab 5 GTPase activating protein , by entering in a complex with Eps 8 , inhibits EGFR internalization . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of epidermal growth factor receptor regulated by Grb 2 mediated recruitment of the Rab 5 GTPase activating protein RN tre . ^^^ |
|
| Interacting proteins: P20936 and P00533 |
Pubmed |
SVM Score :0.0 |
| Enzyme specific regulation of activity is associated with autophosphorylation which leads to reduced ( in case of EGF R ) or increased ( in case of p60c src ) phosphorylation of the C terminal 334 amino acids of ras GAP ( GAP 334 ) . ^^^ Characterization of the C terminal domain of ras GTPase activating protein ( ras GAP ) as substrate for epidermal growth factor receptor and p60c src kinase . ^^^ |
|