| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Identification of a protein that binds to the SH 3 region of Abl and is similar to Bcr and GAP rho . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Both IL 3 and 5 Abl stimulated the tyrosine phosphorylation of SHC and GTPase activating protein . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Binding of full length Crk or the isolated SH 2 domains of GAP or Abl resulted in a significant protection of phosphorylated EGFR against dephosphorylation by cellular phosphatase activity , but did not appear to stimulate the intrinsic tyrosine kinase activity of the EGFR . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| This domain is shared by a number of signal transduction proteins including nonreceptor tyrosine kinases such as Abl , Fps , Src , and Src family members , the transforming protein Crk , phospholipase C gamma 1 , PI 3 ( phosphatidylinositol ) kinase , and guanosine triphosphatase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| In addition , autophosphorylation of ZAP 70 when bound to zeta or eta resulted in the generation of multiple distinct ZAP 70 phosphorylated tyrosine residues which had the capacity to bind the SH 2 domains of fyn , lck , GAP , and abl . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Expression of the catalytic domain of the GTPase activating protein for Ras ( Gap C terminus ) impaired soft agar colony formation by fibroblasts expressing 5 Abl or Bcr Abl by 70 80 % . ^^^ To test Ras function in a model that more closely resembles clinical diseases involving Bcr Abl , double gene retroviruses expressing Bcr Abl paired with the Gap C terminus or dominant negative Ras were introduced into naive mouse bone marrow cells . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| At lower stoichiometry , YAP 65 was also shown to bind to the SH 3 domains of Abl and guanosine triphosphatase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| If an ABL BCR gene product is produced in CML cells , it may be relevant as a mechanism for deregulating the GTPase activating protein ( GAP ) function of BCR . . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domains of PLC gamma Nterm . , Nck , Grb 2 , GAP and Abl have been model built with high affinity phosphopeptides fitted into the putative binding sites . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| The FNR of 1F FISH probes depends on the distance between the BCR and ABL probes hybridized to the BCR ABL fusion gene ( < or =368 kb ) ; the `` gap ' ' between the signals causing the cell to be interpreted as normal . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| A proline rich fragment of the NR2D subunit ( 2D ( 866 1064 ) ) bound to the Abl SH 3 domain but not to the SH 3 domains from Src , Fyn , Grb 2 , GAP , or phospholipase C gamma ( PLCgamma ) . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Fusion proteins containing SH 2 domains from the GTPase activating protein , the p 85 regulatory subunit of phosphatidylinositol 3 ' kinase , or the Abl oncoprotein competed less effectively . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| In contrast , Grb 2 , Crk , Abl , p 85 phosphatidylinositol 3 kinase , and GTPase activating protein SH 2 domains showed lower or no binding to Fyn or Lck SH 3 domains . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| The effects that the N terminal SH 2 domain of Ras GTPase activating protein has in the context of c ABL resemble the effects of deleting the SH 3 domain . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH 2 domains of multiple signalling molecules in vitro , including Grb 2 , Ras GTPase activating protein , phospholipase C gamma , the 85 , 000 M ( r ) subunit of phosphatidylinositol 3 ' kinase , and the Abl tyrosine kinase . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| We report that transient expression of p210bcr / abl in fibroblast like cells induces simultaneous activation of p21ras and inhibition of GTPase promoting activity of p120GAP , and confirm these data showing that downregulation of p210bcr / abl expression in CML cells with bcr / abl antisense oligodeoxynucleotides induces both inhibition of p21ras activation and stimulation of GTPase promoting activity of p120GAP . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Further , rasGAP coimmunoprecipitates with p210BCR / ABL in these cell lines . ^^^ These results suggest that rasGAP or associated proteins are potential substrates for p210BCR / ABL kinase and thus directly link p210BCR / ABL with a signal transduction pathway known to be activated by hematopoietic growth factors ( p21ras ) . . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that the SH 2 domain of BCR ABL is not required for the induction of growth factor independence and is not required for the association of BCR ABL with rasGAP or SHC . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Further , tyrosine phosphorylation of potential substrates of the p210BCR ABL tyrosine kinase , p 120 rasGAP and its associated proteins of p 190 and p 62 , only occurs at the permissive temperature in cells expressing the temperature sensitive mutant . . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| We specifically examined a series of proteins known to be p210BCR / ABL substrates , including rasGAP , Shc , SH PTP 2 , SH PTP 1 , CRK L , CBL , paxillin , and STATs , and found that each were also tyrosine phosphorylated in response to p190BCR / ABL and TEL / ABL . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| In cells , 5 Abl tyrosine kinase binds and strongly phosphorylates p62dok , which then binds rasGAP . ^^^ Identification of the Abl and rasGAP associated 62 kDa protein as a docking protein , Dok . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| A cDNA for p 62 ( dok ) , reported to be the RasGAP associated 62 kDa protein , was recently cloned from Abl transformed cells . ^^^ In 32D myeloid cells and Rat 1 fibroblasts transformed by p 210 ( bcr abl ) , p 62 ( dok ) is tyrosine phosphorylated and co immunoprecipitates with Bcr Abl , RasGAP , and CrkL , a Src homology 2 ( SH 2 ) and SH 3 domain containing adaptor protein . ^^^ |
|
| Interacting proteins: P20936 and P00519 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK associated with p 190 RhoGAP ( p 190 ) , RasGAP , c Abl as well as with the focal adhesion molecules p130cas and paxillin . c Abl was found to be associated with RAFTK through the region of RAFTK containing amino acids 419 1009 . ^^^ |
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