| Interacting proteins: P20800 and P23946 |
Pubmed |
SVM Score :0.0 |
| Chymase processes big endothelin 2 to endothelin 2 ( 1 31 ) that induces contractile responses in the isolated monkey trachea . ^^^ Purified monkey chymase cleaved the Tyr 31 Gly32 bond of big endothelin 1 and big endothelin 2 to yield endothelin 1 ( 1 31 ) and endothelin 2 ( 1 31 ) , respectively . ^^^ Chymostatin , which inhibits chymase , suppressed the contractile response induced by big endothelin 2 to 16 . 6 % but not the responses induced by big endothelin 1 , endothelin 1 ( 1 31 ) and endothelin 2 ( 1 31 ) . ^^^ These results suggest that the contractile response of big endothelin 2 is predominantly dependent on the conversion of big endothelin 2 to endothelin 2 ( 1 31 ) by chymase . . ^^^ |
|
| Interacting proteins: P20800 and P23946 |
Pubmed |
SVM Score :0.0 |
| The effects of endothelin ( ET ) 1 ( 1 31 ) and ET 2 ( 1 31 ) , human chymase products of the corresponding big ETs , on the intracellular free Ca2+ concentration ( [ Ca2+ ] 1 ) and [ 125I ] ET 1 binding were investigated using human cultured bronchial smooth muscle cells ( BSMC ) . ^^^ ET 2 ( 1 31 ) , produced by human chymase from big ET 2 might be important for the generation of ET 2 in human bronchial tissue . . ^^^ |
|
| Interacting proteins: P20800 and P23946 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20800 and P23946 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23946 and P20800 |
Pubmed |
SVM Score :0.0 |
| The effects of endothelin ( ET ) 1 ( 1 31 ) and ET 2 ( 1 31 ) , human chymase products of the corresponding big ETs , on the intracellular free Ca2+ concentration ( [ Ca2+ ] 1 ) and [ 125I ] ET 1 binding were investigated using human cultured bronchial smooth muscle cells ( BSMC ) . ^^^ ET 2 ( 1 31 ) , produced by human chymase from big ET 2 might be important for the generation of ET 2 in human bronchial tissue . . ^^^ |
|
| Interacting proteins: P23946 and P20800 |
Pubmed |
SVM Score :0.0 |
| Chymase processes big endothelin 2 to endothelin 2 ( 1 31 ) that induces contractile responses in the isolated monkey trachea . ^^^ Purified monkey chymase cleaved the Tyr 31 Gly32 bond of big endothelin 1 and big endothelin 2 to yield endothelin 1 ( 1 31 ) and endothelin 2 ( 1 31 ) , respectively . ^^^ Chymostatin , which inhibits chymase , suppressed the contractile response induced by big endothelin 2 to 16 . 6 % but not the responses induced by big endothelin 1 , endothelin 1 ( 1 31 ) and endothelin 2 ( 1 31 ) . ^^^ These results suggest that the contractile response of big endothelin 2 is predominantly dependent on the conversion of big endothelin 2 to endothelin 2 ( 1 31 ) by chymase . . ^^^ |
|
| Interacting proteins: P23946 and P20800 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23946 and P20800 |
Pubmed |
SVM Score :0.0 |
| NA |
|