| Interacting proteins: Q9NQC7 and P20749 |
Pubmed |
SVM Score :0.0 |
| Cyld inhibits tumor cell proliferation by blocking Bcl 3 dependent NF kappaB signaling . ^^^ In Cyld+ / + keratinocytes , TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region , where Cyld binds and deubiquitinates Bcl 3 , thereby preventing nuclear accumulation of Bcl 3 and p50 / Bcl 3 or p52 / Bcl 3 dependent proliferation . ^^^ These data indicate that , depending on the external signals , Cyld can negatively regulate different NF kappaB pathways ; inactivation of TRAF 2 controls survival and inflammation , while inhibition of Bcl 3 controls proliferation and tumor growth . . ^^^ |
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| Interacting proteins: Q9NQC7 and P20749 |
Pubmed |
SVM Score :0.0 |
| In this issue of Cell , Massoumi et al . ( 2006 ) show that CYLD deubiquitinates the coactivator Bcl 3 , thereby preventing its translocation into the nucleus , where it normally interacts with NF kappaB and activates transcription of proliferation genes in response to growth signals . . ^^^ |
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