| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.5177809 |
| Previous studies have indicated that Bcl 3 interacts through its ankyrin repeats with the transcriptional factors NF kappaB 1 ( p 50 ) and NF kappaB 2 ( p 52 ) , affecting their biological activities . 0.5177809^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.52480348 |
| Bcl 3 interacted with NF kappaB p 50 and was recruited to the TNF alpha promoter , but not the IL 6 promoter , indicating that Bcl 3 facilitates p 50 mediated inhibition of TNF alpha expression . 0.52480348^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.8744534 |
| Although previously Bcl 3 was thought to capture 50 kDa NF kappaB 1 isoforms in the cytoplasm , immunoprecipitation ( IP ) and electrophoretic mobility shift assays indicate that nuclear Bcl 3 associates with NF kappaB 1 without affecting DNA binding . 0.8744534^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The candidate oncoprotein Bcl 3 is an antagonist of p50 / NF kappa B mediated inhibition . ^^^ Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl 3 are most closely related to those found in 1 kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF kappa B activity . ^^^ No biological function has yet been described for Bcl 3 , but it was noted recently that Bcl 3 interferes with DNA binding of the p 50 subunit of NF kappa B in vitro . ^^^ Here we demonstrate that Bcl 3 can aid kappa B site dependent transcription in vivo by counteracting the inhibitory effects of p50 / NF kappa B homodimers . ^^^ Bcl 3 may therefore aid activation of select NF kappa B regulated genes , including those of the human immunodeficiency virus . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The bcl 3 protein is able to inhibit the DNA binding and trans activation of authentic NF kappa B heterodimers p 50 p65 and p 49 p65 , as well as p 50 and p 49 homodimers . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Candidate proto oncogene bcl 3 encodes a subunit specific inhibitor of transcription factor NF kappa B . ^^^ We show here that the proto oncogene bcl 3 , believed to be involved in certain human B cell leukaemias , encodes a protein that functions as an 1 kappa B like molecule for native NF kappa B but is specific for the p 50 subunit . ^^^ The ankyrin repeat domain of the bcl 3 product is shown to mediate complex formation with NF kappa B dimers by contracting the conserved dimerization domain of NF kappa B . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Another consistent difference was the presence of a 22 bp duplication in the U 3 portion of the long terminal repeat ( LTR ) of bcl 3 derived viruses that includes the NF kappa B transcriptional enhancer binding site . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The ankyrin repeat domains of the NF kappa B precursor p 105 and the protooncogene bcl 3 act as specific inhibitors of NF kappa B DNA binding . ^^^ These observations identify bcl 3 as an inhibitor of NF kappa B and strongly suggest that the ankyrin repeats in these factors are involved in protein protein interactions with the rel like domain of p 50 . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| These two regions of NF kappa B 2 also mediate preferential synergy with Bcl 3 . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| This gene , BCL 3 , is a member of the 1 kappa B family , whose encoded proteins regulate the NF kappa B family of transcription factors . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| BCL 3 encodes a nuclear protein which can alter the subcellular location of NF kappa B proteins . ^^^ BCL 3 protein acts as an 1 kappa B in that it can specifically inhibit the DNA binding of NF kappa B factors . ^^^ In contrast to 1 kappa B alpha ( MAD 3 ) , BCL 3 does not cause NF kappa B p 50 to be retained in the cytoplasm ; instead , in cotransfection assays , it alters the subnuclear localization of p 50 . ^^^ Results from triple cotransfection experiments with BCL 3 , 1 kappa B alpha , and p 50 implied that BCL 3 can successfully compete with 1 kappa B alpha and bring p 50 into the nucleus ; thus , localization of NF kappa B factors may be affected by differential expression of 1 kappa B proteins . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The candidate proto oncogene bcl 3 encodes a transcriptional coactivator that activates through NF kappa B p 50 homodimers . ^^^ Here , we show that in contrast to the inhibitory activity of 1 kappa B alpha , the bcl 3 gene product superactivates NF kappa B p 50 homodimer mediated gene expression both in vivo and in vitro . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The vertebrate NF kappa B / c rel inhibitors MAD 3 / I kappa B alpha , 1 kappa B gamma / pdI and bcl 3 all share a conserved ankyrin repeat domain ( ARD ) consisting of six complete repeats , a short acidic motif and / or an incomplete seventh repeat . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Bcl 3 protein has seven tandem ankyrin repeats that are also found in 1 kappa B proteins , inhibitors of Rel / NF kappa B transcription factors . ^^^ Bcl 3 preferentially associates with the p 50 of NF kappa B , and the nuclear localization signal of p 50 is required for this association . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Unlike Bcl 3 , an 1 kappa B which has been recently shown to directly transactivate through kappa B sites when associated with NFKB 2 ( p 52 ) , 1 kappa B alpha shows no ability to directly transactivate target promoters via its association with RelA ( p 65 ) . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The oncoprotein Bcl 3 can facilitate NF kappa B mediated transactivation by removing inhibiting p 50 homodimers from select kappa B sites . ^^^ Previously we have proposed a role for Bcl 3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound , non transactivating homodimers of the p 50 subunit of NF kappa B . ^^^ Here we extend the model and provide new evidence which fulfills a number of predictions . ( 1 ) Bcl 3 preferentially targets p 50 homodimers over NF kappa B heterodimers since the homodimers are completely dissociated from kappa B sites at concentrations of Bcl 3 which do not affect NF kappa B . ( 2 ) Select kappa B sites associate very strongly and stably with p 50 homodimers , completely preventing binding by NF kappa B . ^^^ Our data support the model that induction of nuclear Bcl 3 may be required during cellular stimulation to actively remove stably bound p 50 homodimers from certain kappa B sites in order to allow transactivating NF kappa B complexes to engage . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The NF kappa B precursor p 105 and the proto oncogene product Bcl 3 are 1 kappa B molecules and control nuclear translocation of NF kappa B . ^^^ We discuss a function of p 105 as a cytoplasmic assembly unit for homo and heteromeric NF kappa B complexes and of Bcl 3 as an 1 kappa B with novel subunit specificity . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The bcl 3 proto oncogene encodes a nuclear 1 kappa B like molecule that preferentially interacts with NF kappa B p 50 and p 52 in a phosphorylation dependent manner . ^^^ In vitro , Bcl 3 protein specifically inhibited the DNA binding of both the homodimeric NF kappa B p 50 subunit and a closely related homolog , p 52 ( previously p 49 ) , to immunoglobulin kappa NF kappa B DNA motifs . ^^^ At concentrations that significantly inhibited DNA binding by homodimeric p 50 , Bcl 3 did not inhibit binding of reconstituted heterodimeric NF kappa B ( p 50 : p 65 ) , a DNA binding homodimeric form of p 65 , or homodimers of c Rel . ^^^ These properties contrast Bcl 3 to classically defined 1 kappa B , which maintains heterodimeric NF kappa B p 50 : p 65 in the cytoplasm through specific interactions with the p 65 subunit . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The translocation does not interrupt the transcriptional integrity of BCL 3 , but is associated with overexpression of this gene , which encodes an 1 kappa B like protein and modulates the activity of the NF kappa B transcription factors . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Previously , we have shown that Bcl 3 , a distinct member of the 1 kappa B family , may function as a positive regulator of NF kappa B activity , although its physiologic roles remained unknown . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Regulation of NFKB 1 proteins by the candidate oncoprotein BCL 3 : generation of NF kappaB homodimers from the cytoplasmic pool of p 50 p105 and nuclear translocation . ^^^ The candidate oncoprotein BCL 3 has been shown to function as a transcriptional co activator for homodimers of NF kappaB p 50 and p50B . ^^^ Instead , BCL 3 mediated reorganization of NFKB 1 subunits was demonstrated in vitro . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The activation of NF kappa B after hemorrhage was accompanied by alterations in levels of the NF kappa B regulatory proteins 1 kappa B alpha and Bcl 3 . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Diverse effects of BCL 3 phosphorylation on its modulation of NF kappaB p 52 homodimer binding to DNA . ^^^ BCL 3 is a nuclear IkappaB that can inhibit or enhance the binding of NF kappaB p 50 or p 52 homodimers to consensus DNA binding ( kappaB ) sequences or form a kappaB binding complex with homodimers . ^^^ These results indicate that BCL 3 phosphorylation may affect its regulation of NF kappaB dependent transcription in vivo . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Sp 1 can activate transcription through immunoglobulin kappa chain enhancer or P selectin promoter NF kappaB sites . p 50 homodimers replace Sp 1 from the P selectin promoter by binding site competition and thereby either inhibit basal Sp 1 driven expression or , in concert with Bcl 3 , stimulate expression . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Signal dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF kappaB , bcl 3 or p 53 . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| As a member of the 1 kappaB family , BCL 3 plays a role in the immune response by interactions with the NF kappaB family of transcription factors . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Bcl 3 in TF 1 cells by transient transfection along with the NF kappaB factors p 50 or p 52 resulted in significant induction of an human immunodeficiency virus type 1 ( HIV 1 ) kappaB TATA luceriferase reporter plasmid , demonstrating that Bcl 3 has a positive role in transactivation of kappaB containing genes in erythroid cells . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Interleukin 9 regulates NF kappaB activity through BCL 3 gene induction . ^^^ BCL 3 encodes a protein with close homology to IkappaB proteins and interacts with p 50 NF kappaB homodimers . ^^^ Moreover , IL 9 stimulation or BCL 3 transient transfection similarly inhibited NF kappaB mediated transcription in response to TNF . ^^^ Taken together , our observations show a new regulatory pathway for the NF kappaB transcription factors through STAT dependent upregulation of BCL 3 gene expression . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The Bcl 3 oncoprotein acts as a bridging factor between NF kappaB / Rel and nuclear co regulators . ^^^ Using the yeast two hybrid system we identified four novel binding partners of Bcl 3 in addition to NF kappaB p 50 and p 52 , previously known to associate with Bcl 3 . ^^^ Bcl 3 , p 50 , and either Bard 1 , Tip 60 or Pirin are sequestered into quarternary complexes on NF kappaB DNA binding sites , whereas Jab 1 enhances p 50 Bcl 3 DNA complex formation . ^^^ Furthermore , the histone acetylase Tip 60 enhances Bcl 3 p 50 activated transcription through an NF kappaB binding site , indicating that quarternary complexes containing Bcl 3 interactors modulate NF kappaB driven gene expression . ^^^ These data implicate Bcl 3 as an adaptor between NF kappaB p50 / p52 and other transcription regulators and suggest that its gene activation function may at least in part be due to recruitment of the Tip 60 histone actetylase . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| To investigate whether transcription factors of the NF kappa B family could play a role in early mammalian development , we have analyzed the expression of nfkb 1 , nfkb 2 , c Rel , RelA , RelB , and bcl 3 from 6 . 5 to 10 . 5 day mouse embryo implantation sites . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB p 105 is a target of IkappaB kinases and controls signal induction of Bcl 3 p 50 complexes . ^^^ We propose a model that p 105 is inducibly degraded , and that its degradation liberates sequestered NF kappaB subunits , including its processing product p 50 . p 50 homodimers are specifically bound by the transcription activator Bcl 3 . ^^^ Thus , the known NF kappaB stimuli not only cause nuclear accumulation of p 50 p65 heterodimers but also of Bcl 3 p 50 and perhaps further transcription activator complexes which are formed upon IKK mediated p 105 degradation . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Distinct activities of p52 / NF kappa B required for proper secondary lymphoid organ microarchitecture : functions enhanced by Bcl 3 . ^^^ Mice rendered deficient in p 52 , a subunit of NF kappa B , or in Bcl 3 , an 1 kappa B related regulator that associates with p 52 homodimers , share defects in the microarchitecture of secondary lymphoid organs . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this setting , appropriate counterregulatory mechanisms to normalize nuclear levels of NF kappaB and to suppress NF kappaB mediated transcription , such as increased cytoplasmic and nuclear IkappaBalpha levels or decreased Bcl 3 levels , appeared to be induced . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Selective activation of NF kappa B subunits in human breast cancer : potential roles for NF kappa B2 / p52 and for Bcl 3 . ^^^ These data suggest a potential role for a subset of NF kappa B and 1 kappa B family proteins , particularly NF kappa B / p52 and Bcl 3 , in human breast cancer . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| As determined by electrophoretic mobility shift assays , antiserum against the NF kappaB binding protein , p 50 , retarded the mobility of the inducible complex , whereas antisera against p 52 , p 65 , c Rel , Rel B , IkappaB alpha , IkappaB gamma , and Bcl 3 had no effect . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappa B inducible BCL 3 expression is an autoregulatory loop controlling nuclear p50 / NF kappa B 1 residence . ^^^ Here we examine the role of inducible cytoplasmic BCL 3 expression in terminating nuclear NF kappa B 1 . ^^^ Cytoplasmic BCL 3 abundance is induced 6 12 h after tumor necrosis factor alpha stimulation where it complexes with NF kappa B 1 homodimers . ^^^ Moreover , BCL 3 mRNA and protein expression are induced by NF kappa B activating agents . ^^^ Two observations are interpreted to indicate that bcl 3 is transactivated by NF kappa B / Rel A : 1 ) expression of a dominant negative NF kappa B inhibitor blocks tumor necrosis factor alpha induced BCL 3 expression and 2 ) expression of constitutively active Rel A is sufficient to induce BCL 3 expression . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Human PIRIN stabilizes the formation of quaternary complexes between Bcl 3 , the anti apoptotic transcription factor NF kappaB and its DNA target sequences in vitro . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Bcl 3 is an unusual IkappaB protein because it is primarily nucleoplasmic and can lead to enhanced NF kappaB dependent transcription , unlike the prototypical IkappaB protein IkappaBalpha , which inhibits NF kappaB activity by retaining it in the cytoplasm . ^^^ Here we report the 1 . 9 A crystal structure of the ankyrin repeat domain of human Bcl 3 and compare it with that of IkappaBalpha bound to NF kappaB . ^^^ Differences between the two structures suggest why Bcl 3 differs from IkappaBalpha in selectivity towards various NF kappaB species , why Bcl 3 but not IkappaBalpha can associate with its NF kappaB partner bound to DNA , and why two molecules of Bcl 3 but only one of IkappaBalpha can bind to its NF kappaB partner . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Bcl 3 is a distinctive member of the IkappaB family of NF kappaB inhibitors because it can function to coactivate transcription . ^^^ Upon further analysis , Bcl 3 , acting as a coactivator with NF kappaB p 52 homodimers , was demonstrated to directly activate the cyclin D 1 promoter through an NF kappaB binding site . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| There was increased binding to an NF kappaB consensus oligonucleotide , and this complex bound antibodies to p 50 , c Rel , and Bcl 3 but not other NF kappaB family members . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The anti apoptotic B cell lymphoma 3 ( Bcl 3 ) protein and the transcription factor NF kappaB p 52 subunit were upregulated in infected PBMCs both at the mRNA and at the protein level . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Finally , adjuvants that enable T cell survival may operate via NF kappaB and Bcl 3 rather than cytokines . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Abnormal organogenesis of Peyer ' s patches in mice deficient for NF kappaB 1 , NF kappaB 2 , and Bcl 3 . ^^^ METHODS : NF kappaB 1 , NF kappaB 2 , and Bcl 3 deficient mouse lines were established , and their role in organogenesis of Peyer ' s patches ( PP ) was investigated . ^^^ RESULTS : Macroscopic inspection showed a reduced number and size of PP in Bcl 3 ( / ) and NF kappaB 1 ( / ) mice but failed to detect PP in NF kappaB 2 ( / ) mice . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 , Bcl 3 , NF kappaB ( 2 ) , and CD 40 CD40L ligand interaction are important for up regulation of IFN gamma production . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To define the role of Bcl 3 , a member of the inhibitor of nuclear factor kappaB ( NF kappaB ) family and a known regulator of NF kappaB , in interleukin 1 ( IL 1 ) induced matrix metalloproteinase 1 ( MMP 1 ) transcription in chondrocytes and synovial fibroblasts . ^^^ SW 1353 cells and rabbit synovial fibroblasts were transfected with a 4 . 3 kb human MMP 1 promoter construct along with Bcl 3 and NF kappaB 1 expression constructs , and MMP 1 transcription was assayed . ^^^ We showed here that Bcl 3 can cooperate with NF kappaB 1 to activate MMP 1 transcription in SW 1353 cells . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found a synergistic induction of the NF kappaB target genes BCL 3 , Dif 2 , and TNF receptor 2 ( TNFR 2 ) in response to the combination of TNF and ATRA . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| D 1 transcription through down regulation of Bcl 3 and inducing increased association of the p 52 NF kappaB subunit with histone deacetylase 1 . ^^^ This repression was dependent on the proximal NF kappaB binding site of the cyclin D 1 promoter , which has been shown to bind the p 52 NF kappaB subunit . p 53 inhibited the expression of Bcl 3 protein , a member of the IkappaB family that functions as a transcriptional coactivator for p 52 NF kappaB and also reduced p52 / Bcl 3 complex levels . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The NF kappaB2 / p100 and bcl 3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias ( CLL ) and non Hodgkin ' s lymphomas , and nuclear factor kappaB ( NF kappaB ) protects cancer cells against apoptosis . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| We compared gene expression profiles of 4 ALCL ( Karpas 299 , SU DHL 1 , DEL , SR 786 ) and 3 HD cell lines and found that BCL 3 , which encodes a nuclear protein belonging to the 1 kappa B family of inhibitors of nuclear factor kappa B ( NF kappa B ) transcriptional factors , was expressed at higher levels in ALCL than HD . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Analysis of the composition of NF kappaB complexes in the tumors revealed aberrant nuclear expression of multiple subunits , including c Rel , p 50 , p 52 , RelA , RelB , and the Bcl 3 protein , as observed previously in human primary breast cancers . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Further , induced expression of Bcl 3 , a trans activating IkappaB like protein , is decreased in T cells as a consequence of NF kappaB inhibition . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that IL 1 induces expression of the inhibitor of NF kappaB ( IkappaB ) family member Bcl 3 , and that this contributes to MMP 1 expression . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Estrogen withdrawal induced NF kappaB activity and bcl 3 expression in breast cancer cells : roles in growth and hormone independence . ^^^ We show here that ER ( + ) , E 2 independent MCF 7 / LCC1 cells derived from E 2 dependent MCF 7 cells contain elevated basal NF kappaB activity and elevated expression of the transcriptional coactivator Bcl 3 compared with the parental MCF 7 line . ^^^ Estrogen withdrawal increases both NF kappaB DNA binding activity and expression of Bcl 3 in MCF 7 and LCC 1 cells in vitro and in vivo . ^^^ Thus , both p50 / Bcl 3 and p65 / p50 associated NF kappaB activities are activated early in progression and serve differential roles in growth and hormone independence , respectively . ^^^ We propose that E 2 withdrawal may initiate selection for hormone independence in breast cancer cells by activation of NF kappaB and Bcl 3 , which could then supplant E 2 by providing both survival and growth signals . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappa B regulates BCL 3 transcription in T lymphocytes through an intronic enhancer . ^^^ Together , these results demonstrate a critical role for NF kappaB in BCL 3 transcriptional up regulation by TCR mimetic signals . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| These findings suggest an enzymatic role for Pirin , most likely in biological redox reactions involving oxygen , and provide compelling evidence that Pirin requires the participation of the metal ion for its interaction with Bcl 3 to co regulate the NF kappaB transcription pathway and the interaction with NFI in DNA replication . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation assays indicate that homodimers are bound to the transcriptional coactivator Bcl 3 , and chromatin immunoprecipitation indicates that this complex is bound to NF kappaB consensus motifs within the egfr promoter in NPC . ^^^ The discrete yet striking NF kappaB p 50 activation in NPC suggests that p50 / p50 homodimers may be important factors in the development of NPC and may contribute to oncogenesis through transcriptional up regulation of target genes through their interaction with Bcl 3 . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| BCL 3 and NF kappaB p 50 attenuate lipopolysaccharide induced inflammatory responses in macrophages . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The oncoprotein BCL 3 is a nuclear transcription factor that activates NF kappaB target genes through formation of heterocomplexes with p 50 or p 52 . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical evaluation included members of the NF kappaB ( p 50 , p 65 , p 52 , c Rel , Rel B ) and the IkappaB ( IkappaBalpha , IkappaBbeta , IkappaBepsilon , Bcl 3 ) families , as well as putative targets of NF kappaB such as Flip , Bcl xL , Cyclin D 1 , and oestrogen and progesterone receptors . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Disruption of either the Nfkb 1 or the Bcl 3 gene inhibits skeletal muscle atrophy . ^^^ Previously we showed that the activity of an NF kappaB dependent reporter gene was markedly increased in unloaded muscles , and p 50 and Bcl 3 proteins were implicated in this induction . ^^^ Knockout of the B cell lymphoma 3 ( Bcl 3 ) gene also showed an inhibition of fiber atrophy and an abolition of NF kappaB reporter activity . ^^^ The slow to fast shift in myosin isoform expression due to unloading was also abolished in both Nfkb 1 and Bcl 3 knockout mice . ^^^ Like the soleus muscles , plantaris muscles from Nfkb 1 ( / ) and Bcl 3 ( / ) mice also showed inhibition of atrophy with unloading . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The observed increase in cytoplasmic phosphorylated inhibitor kappaBalpha ( IkappaBalpha ) and nuclear translocation of Bcl 3 24 h after HI was also significantly attenuated by IL 1Ra blockade , suggesting that HI induced IL 1 activation of NF kappaB is via both the degradation of IkappaBalpha and the nuclear translocation of Bcl 3 . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| These data indicate that Bcl 3 and RelB exert distinct and opposing effects on the expression of subset determining transcription factors , suggesting that the characteristics of Th cell responses may be regulated by titrating the stoichiometry of transactivating NF kappaB / Rel / IkappaB complexes in the nuclei of developing helper effector cells . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Bcl 3 is a unique IkappaB family protein that regulates transcription of a number of NF kappaB target genes through interactions with NF kappaB dimers . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| As Bcl 3 can act as an anti repressor or transactivator or both , we propose that the ( p 52 ) 2 / Bcl 3P ternary complex , which is specifically induced in CD 30 stimulated ALCL , can modulate expression of apoptosis related genes regulated by NF kappaB , thereby accounting for CD 30 mediated apoptosis of ALCL . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 is up regulated by NF kappaB and phosphorylated by Akt 1 and then complexes with Bcl 3 to enter the nucleus . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The transcription factor NF kappaB and associated regulatory factors ( including IkappaB kinase subunits and the IkappaB family member Bcl 3 ) are strongly implicated in a variety of hematologic and solid tumor malignancies . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Cyld inhibits tumor cell proliferation by blocking Bcl 3 dependent NF kappaB signaling . ^^^ The cyclin D 1 elevation is caused not by increased p65 / p50 action but rather by increased nuclear activity of Bcl 3 associated NF kappaB p 50 and p 52 . ^^^ These data indicate that , depending on the external signals , Cyld can negatively regulate different NF kappaB pathways ; inactivation of TRAF 2 controls survival and inflammation , while inhibition of Bcl 3 controls proliferation and tumor growth . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this issue of Cell , Massoumi et al . ( 2006 ) show that CYLD deubiquitinates the coactivator Bcl 3 , thereby preventing its translocation into the nucleus , where it normally interacts with NF kappaB and activates transcription of proliferation genes in response to growth signals . . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| Elevated NF kappaB p 50 complex formation and Bcl 3 expression in classical Hodgkin , anaplastic large cell , and other peripheral T cell lymphomas . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| The NF kappaB regulator Bcl 3 and the BH 3 only proteins Bim and Puma control the death of activated T cells . ^^^ Here we show that adjuvant stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF kappaB regulator Bcl 3 and the proapoptotic Bcl 2 family members Bim and Puma . ^^^ |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20749 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|