| Interacting proteins: P20719 and Q15672 |
Pubmed |
SVM Score :0.0 |
| HOXA 5 twist interaction alters p 53 homeostasis in breast cancer cells . ^^^ Searching for potential protein interacting partners we found that HOXA 5 binds to an anti apoptotic protein , Twist . ^^^ Using a p 53 promoter reporter system , we demonstrated that HOXA 5 could partially restore the inhibitory effects of Twist on p 53 target genes . ^^^ These effects are likely mediated through both the transcriptional up regulation of p 53 and the protein protein interaction between HOXA 5 and Twist . ^^^ Thus , the loss of HOXA 5 expression could lead to the functional activation of Twist resulting in aberrant cell cycle regulation and promoting breast carcinogenesis . . ^^^ |
|
| Interacting proteins: Q15672 and P20719 |
Pubmed |
SVM Score :0.0 |
| HOXA 5 twist interaction alters p 53 homeostasis in breast cancer cells . ^^^ Searching for potential protein interacting partners we found that HOXA 5 binds to an anti apoptotic protein , Twist . ^^^ Using a p 53 promoter reporter system , we demonstrated that HOXA 5 could partially restore the inhibitory effects of Twist on p 53 target genes . ^^^ These effects are likely mediated through both the transcriptional up regulation of p 53 and the protein protein interaction between HOXA 5 and Twist . ^^^ Thus , the loss of HOXA 5 expression could lead to the functional activation of Twist resulting in aberrant cell cycle regulation and promoting breast carcinogenesis . . ^^^ |
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